ENSG00000138430

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000344357 ENSG00000138430 HEK293_OSMI2_2hA HEK293_TMG_2hB OLA1 protein_coding protein_coding 106.1625 62.05275 162.1562 5.289555 3.847938 1.385674 40.040289 31.572994 51.34787 3.3460567 1.744008 0.7014373 0.40267500 0.50710000 0.31653333 -0.19056667 3.284979e-19 3.284979e-19 FALSE TRUE
ENST00000428402 ENSG00000138430 HEK293_OSMI2_2hA HEK293_TMG_2hB OLA1 protein_coding protein_coding 106.1625 62.05275 162.1562 5.289555 3.847938 1.385674 8.140988 4.997748 10.98514 1.1962350 2.150191 1.1346324 0.07805417 0.07873333 0.06716667 -0.01156667 8.341350e-01 3.284979e-19 FALSE TRUE
MSTRG.19514.2 ENSG00000138430 HEK293_OSMI2_2hA HEK293_TMG_2hB OLA1 protein_coding   106.1625 62.05275 162.1562 5.289555 3.847938 1.385674 55.495820 24.844091 95.84970 0.8140874 1.755392 1.9474410 0.49890417 0.40393333 0.59163333 0.18770000 9.750809e-06 3.284979e-19 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000138430 E001 29.5910289 0.0006527105 2.205228e-05 1.353596e-04 2 174072447 174074397 1951 - 1.558 1.269 -0.999
ENSG00000138430 E002 3.5114245 0.1335897150 4.586762e-01 5.989837e-01 2 174074398 174074475 78 - 0.700 0.526 -0.767
ENSG00000138430 E003 20.1077938 0.0338788563 8.985122e-01 9.392827e-01 2 174074476 174075007 532 - 1.313 1.315 0.004
ENSG00000138430 E004 16.5148102 0.0108047818 5.390972e-01 6.703945e-01 2 174075008 174075009 2 - 1.208 1.288 0.282
ENSG00000138430 E005 389.6024219 0.0039196692 9.587531e-10 1.426698e-08 2 174075010 174075189 180 - 2.479 2.711 0.775
ENSG00000138430 E006 269.6839241 0.0048558375 3.224377e-08 3.608723e-07 2 174075190 174075236 47 - 2.316 2.555 0.796
ENSG00000138430 E007 497.3557000 0.0012383470 6.544697e-18 3.278354e-16 2 174075237 174075385 149 - 2.595 2.806 0.702
ENSG00000138430 E008 387.1839394 0.0027315786 1.519657e-06 1.213516e-05 2 174075386 174075408 23 - 2.509 2.667 0.524
ENSG00000138430 E009 639.9137482 0.0002038403 1.708060e-10 2.896409e-09 2 174075409 174075527 119 - 2.747 2.861 0.379
ENSG00000138430 E010 785.8388746 0.0006886640 4.612221e-01 6.012146e-01 2 174078968 174079090 123 - 2.870 2.898 0.091
ENSG00000138430 E011 6.9339953 0.0069304412 1.186310e-02 3.320229e-02 2 174079091 174079351 261 - 0.976 0.637 -1.344
ENSG00000138430 E012 4.6607029 0.0050643272 4.555472e-05 2.592665e-04 2 174080908 174081151 244 - 0.885 0.169 -3.810
ENSG00000138430 E013 733.7015988 0.0005468819 5.207767e-01 6.547232e-01 2 174081152 174081248 97 - 2.841 2.867 0.087
ENSG00000138430 E014 690.1518112 0.0001105634 6.548201e-01 7.648948e-01 2 174081924 174082009 86 - 2.817 2.840 0.079
ENSG00000138430 E015 508.4176971 0.0001426724 1.851682e-01 3.076992e-01 2 174082010 174082064 55 - 2.679 2.719 0.132
ENSG00000138430 E016 507.2680538 0.0001315077 4.991829e-01 6.355168e-01 2 174123180 174123277 98 - 2.682 2.710 0.095
ENSG00000138430 E017 611.6845174 0.0005015663 4.677503e-02 1.034230e-01 2 174123595 174123675 81 - 2.780 2.762 -0.063
ENSG00000138430 E018 0.4470576 0.0214351694 1.000000e+00 1.000000e+00 2 174124264 174124315 52 - 0.160 0.169 0.094
ENSG00000138430 E019 934.1206304 0.0001975918 7.853389e-11 1.410372e-09 2 174141825 174142000 176 - 2.980 2.910 -0.234
ENSG00000138430 E020 0.5244761 0.3059525635 9.190664e-01 9.528773e-01 2 174217872 174217946 75 - 0.160 0.172 0.120
ENSG00000138430 E021 417.3649112 0.0001427319 4.371728e-05 2.498038e-04 2 174223033 174223056 24 - 2.627 2.568 -0.199
ENSG00000138430 E022 680.4552046 0.0001565641 5.124899e-09 6.675124e-08 2 174223057 174223160 104 - 2.843 2.771 -0.238
ENSG00000138430 E023 778.8444543 0.0001438710 1.999070e-14 6.290994e-13 2 174229308 174229451 144 - 2.908 2.816 -0.306
ENSG00000138430 E024 574.9942295 0.0001226396 3.110340e-16 1.258801e-14 2 174246715 174246815 101 - 2.784 2.668 -0.386
ENSG00000138430 E025 0.1482932 0.0404747980 2.375754e-01   2 174246928 174247287 360 - 0.000 0.169 9.502
ENSG00000138430 E026 1.7349610 0.0081305163 2.859234e-01 4.262894e-01 2 174247670 174248451 782 - 0.478 0.291 -1.073
ENSG00000138430 E027 392.8588242 0.0007886209 1.062421e-12 2.595725e-11 2 174248452 174248599 148 - 2.629 2.478 -0.502