ENSG00000138413

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000345146 ENSG00000138413 HEK293_OSMI2_2hA HEK293_TMG_2hB IDH1 protein_coding protein_coding 25.8138 17.70041 32.60624 3.207067 0.9844862 0.8809928 24.10917 17.11865 29.49789 3.209911 0.811035 0.7846895 0.9284833 0.9654 0.9049 -0.0605 0.009056088 8.644317e-05 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000138413 E001 1.6531969 0.0082969965 6.229155e-04 2.616676e-03 2 208236229 208236231 3 - 0.095 0.689 3.987
ENSG00000138413 E002 12.3124882 0.0014412764 3.171326e-13 8.392210e-12 2 208236232 208236264 33 - 0.670 1.423 2.793
ENSG00000138413 E003 329.5808887 0.0052963634 1.391322e-14 4.489554e-13 2 208236265 208236741 477 - 2.360 2.675 1.050
ENSG00000138413 E004 367.8932599 0.0012120977 1.265193e-05 8.212113e-05 2 208236742 208237169 428 - 2.510 2.637 0.422
ENSG00000138413 E005 211.9442676 0.0002520176 8.978635e-01 9.387955e-01 2 208239071 208239233 163 - 2.315 2.345 0.099
ENSG00000138413 E006 203.1162377 0.0026964995 7.980144e-01 8.711104e-01 2 208239863 208240003 141 - 2.293 2.329 0.120
ENSG00000138413 E007 4.8371458 0.0033135819 5.929912e-02 1.254342e-01 2 208240004 208240315 312 - 0.853 0.605 -1.018
ENSG00000138413 E008 209.3615261 0.0002764795 3.464908e-01 4.906117e-01 2 208241994 208242145 152 - 2.321 2.324 0.010
ENSG00000138413 E009 218.1771744 0.0007356230 1.327210e-01 2.378836e-01 2 208243427 208243604 178 - 2.344 2.327 -0.058
ENSG00000138413 E010 118.8053943 0.0060028778 4.412309e-02 9.861018e-02 2 208245319 208245366 48 - 2.107 2.019 -0.297
ENSG00000138413 E011 133.2709431 0.0027058501 2.907418e-05 1.735573e-04 2 208245367 208245424 58 - 2.178 2.027 -0.504
ENSG00000138413 E012 9.7255228 0.0038260914 5.100257e-05 2.868338e-04 2 208247382 208248368 987 - 1.161 0.689 -1.792
ENSG00000138413 E013 231.5911102 0.0002391819 3.893595e-07 3.518197e-06 2 208248369 208248561 193 - 2.399 2.303 -0.321
ENSG00000138413 E014 111.8957834 0.0013679648 4.571914e-03 1.474223e-02 2 208248562 208248596 35 - 2.081 1.997 -0.283
ENSG00000138413 E015 134.8728752 0.0007016191 3.112748e-02 7.415101e-02 2 208248597 208248660 64 - 2.147 2.101 -0.155
ENSG00000138413 E016 0.3299976 0.0274424043 9.488619e-02   2 208251261 208251429 169 - 0.000 0.270 11.984
ENSG00000138413 E017 189.4907482 0.0043251321 7.740073e-02 1.552964e-01 2 208251430 208251567 138 - 2.298 2.241 -0.189
ENSG00000138413 E018 153.0990897 0.0045316718 5.361169e-02 1.155732e-01 2 208253886 208253959 74 - 2.210 2.143 -0.222
ENSG00000138413 E019 1.3811423 0.3425029348 2.682262e-01 4.066669e-01 2 208253960 208254030 71 - 0.473 0.157 -2.184
ENSG00000138413 E020 3.5960811 0.0476011731 1.931315e-02 5.001252e-02 2 208254031 208254342 312 - 0.788 0.361 -1.987
ENSG00000138413 E021 2.2302948 0.0072552122 3.759510e-04 1.681171e-03 2 208254343 208254458 116 - 0.670 0.000 -13.529
ENSG00000138413 E022 142.9840363 0.0014273505 4.278530e-04 1.881423e-03 2 208254939 208255059 121 - 2.193 2.094 -0.332
ENSG00000138413 E023 31.3995065 0.0006720114 2.557032e-02 6.306042e-02 2 208255060 208255113 54 - 1.554 1.437 -0.401
ENSG00000138413 E024 0.8179419 0.0157789968 9.126351e-01 9.486331e-01 2 208255529 208255589 61 - 0.239 0.271 0.235
ENSG00000138413 E025 0.2214452 0.0563653410 2.903214e-01   2 208255590 208255798 209 - 0.000 0.157 10.991
ENSG00000138413 E026 0.8449086 0.0145780373 5.533844e-02 1.185738e-01 2 208265970 208266074 105 - 0.095 0.436 2.819