ENSG00000138411

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000642884 ENSG00000138411 HEK293_OSMI2_2hA HEK293_TMG_2hB HECW2 protein_coding processed_transcript 0.6882845 0.4837687 1.192415 0.01242986 0.03922155 1.284027 0.01898129 0.00000000 0.08498154 0.00000000 0.08498154 3.2476471 0.0169625 0.00000000 0.06916667 0.06916667 9.532352e-01 4.488831e-06   FALSE
ENST00000644030 ENSG00000138411 HEK293_OSMI2_2hA HEK293_TMG_2hB HECW2 protein_coding protein_coding 0.6882845 0.4837687 1.192415 0.01242986 0.03922155 1.284027 0.32702170 0.04524299 0.67466960 0.04524299 0.03749808 3.6315448 0.4352833 0.09856667 0.56610000 0.46753333 7.819365e-03 4.488831e-06 FALSE TRUE
ENST00000644421 ENSG00000138411 HEK293_OSMI2_2hA HEK293_TMG_2hB HECW2 protein_coding protein_coding 0.6882845 0.4837687 1.192415 0.01242986 0.03922155 1.284027 0.07361604 0.25128556 0.00000000 0.06065353 0.00000000 -4.7075555 0.1484167 0.51433333 0.00000000 -0.51433333 4.488831e-06 4.488831e-06 FALSE TRUE
ENST00000644978 ENSG00000138411 HEK293_OSMI2_2hA HEK293_TMG_2hB HECW2 protein_coding protein_coding 0.6882845 0.4837687 1.192415 0.01242986 0.03922155 1.284027 0.19287560 0.17413258 0.31961674 0.03223883 0.09791999 0.8400446 0.2791125 0.35936667 0.27063333 -0.08873333 7.715531e-01 4.488831e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000138411 E001 0.0000000       2 196189099 196189349 251 -      
ENSG00000138411 E002 10.1657007 0.0199528266 6.020804e-07 5.243521e-06 2 196194072 196195271 1200 - 0.722 1.329 2.250
ENSG00000138411 E003 29.2324152 0.0009439994 6.507699e-02 1.351587e-01 2 196195272 196199250 3979 - 1.479 1.378 -0.347
ENSG00000138411 E004 0.5159433 0.2281158912 8.715687e-01 9.213758e-01 2 196199251 196199255 5 - 0.148 0.184 0.376
ENSG00000138411 E005 0.5159433 0.2281158912 8.715687e-01 9.213758e-01 2 196199256 196199271 16 - 0.148 0.184 0.376
ENSG00000138411 E006 0.5159433 0.2281158912 8.715687e-01 9.213758e-01 2 196199272 196199274 3 - 0.148 0.184 0.376
ENSG00000138411 E007 3.4676251 0.0053824458 4.977437e-03 1.586728e-02 2 196199275 196199336 62 - 0.420 0.860 1.940
ENSG00000138411 E008 44.5031274 0.0148406169 6.128779e-05 3.378175e-04 2 196199337 196201388 2052 - 1.510 1.810 1.020
ENSG00000138411 E009 8.1063061 0.0022101641 3.520231e-01 4.962661e-01 2 196215865 196215977 113 - 0.951 0.860 -0.346
ENSG00000138411 E010 7.6644704 0.0022849834 9.795456e-01 9.912563e-01 2 196217008 196217093 86 - 0.899 0.918 0.074
ENSG00000138411 E011 0.7258635 0.9249055490 5.974433e-01 7.191938e-01 2 196217094 196218259 1166 - 0.302 0.000 -11.831
ENSG00000138411 E012 8.0405489 0.0021515424 1.579275e-01 2.723713e-01 2 196220039 196220153 115 - 0.852 1.037 0.695
ENSG00000138411 E013 10.6352825 0.0031449492 2.236210e-01 3.547240e-01 2 196220795 196220941 147 - 0.980 1.130 0.546
ENSG00000138411 E014 5.9034720 0.0029890773 4.492526e-01 5.904564e-01 2 196222211 196222229 19 - 0.770 0.890 0.469
ENSG00000138411 E015 9.2301973 0.0022827639 8.462418e-01 9.044148e-01 2 196222230 196222340 111 - 0.971 1.015 0.165
ENSG00000138411 E016 7.8390652 0.0052774992 4.883530e-01 6.259355e-01 2 196225772 196225870 99 - 0.888 0.993 0.394
ENSG00000138411 E017 5.4593459 0.0774662962 1.609550e-01 2.763648e-01 2 196228102 196228254 153 - 0.687 0.961 1.075
ENSG00000138411 E018 0.0000000       2 196238494 196240448 1955 -      
ENSG00000138411 E019 3.4782513 0.0045324814 4.828562e-01 6.209739e-01 2 196240449 196240562 114 - 0.586 0.713 0.545
ENSG00000138411 E020 5.3605380 0.0035424793 1.171773e-01 2.159151e-01 2 196242084 196242204 121 - 0.826 0.615 -0.868
ENSG00000138411 E021 0.1515154 0.0424600227 1.000000e+00   2 196242205 196242826 622 - 0.081 0.000 -10.667
ENSG00000138411 E022 6.1764062 0.0028042390 1.141152e-02 3.214348e-02 2 196253920 196254029 110 - 0.910 0.557 -1.454
ENSG00000138411 E023 0.0000000       2 196257736 196257822 87 -      
ENSG00000138411 E024 5.0962315 0.0032414404 1.864868e-02 4.856204e-02 2 196257823 196257906 84 - 0.839 0.489 -1.504
ENSG00000138411 E025 0.0000000       2 196258010 196258101 92 -      
ENSG00000138411 E026 0.0000000       2 196269306 196269492 187 -      
ENSG00000138411 E027 5.3813775 0.0032970960 1.177486e-01 2.167191e-01 2 196271193 196271289 97 - 0.826 0.615 -0.868
ENSG00000138411 E028 5.7770530 0.0032274039 2.919747e-01 4.329063e-01 2 196274021 196274123 103 - 0.839 0.713 -0.504
ENSG00000138411 E029 5.1286094 0.0033537706 2.928751e-01 4.338952e-01 2 196278528 196278662 135 - 0.799 0.667 -0.540
ENSG00000138411 E030 0.0000000       2 196278663 196278692 30 -      
ENSG00000138411 E031 0.1817044 0.0399554028 1.999279e-01   2 196288021 196292564 4544 - 0.000 0.182 12.054
ENSG00000138411 E032 8.3082852 0.0023639144 3.107091e-01 4.531366e-01 2 196292565 196292750 186 - 0.961 0.860 -0.383
ENSG00000138411 E033 6.8646026 0.0024205312 8.907747e-02 1.737177e-01 2 196306488 196306612 125 - 0.921 0.713 -0.816
ENSG00000138411 E034 5.1274515 0.0033142190 1.419857e-01 2.507530e-01 2 196307130 196307233 104 - 0.813 0.615 -0.816
ENSG00000138411 E035 3.5074979 0.0047040643 8.312188e-01 8.942031e-01 2 196307935 196308085 151 - 0.629 0.615 -0.061
ENSG00000138411 E036 0.0000000       2 196308086 196308156 71 -      
ENSG00000138411 E037 0.6234634 0.0205070702 6.249226e-02 1.308347e-01 2 196315781 196317273 1493 - 0.080 0.408 2.935
ENSG00000138411 E038 4.0404061 0.2247950274 9.037512e-01 9.427559e-01 2 196317274 196317369 96 - 0.671 0.677 0.026
ENSG00000138411 E039 26.6630831 0.0026968456 1.098498e-02 3.112582e-02 2 196318552 196319904 1353 - 1.461 1.295 -0.575
ENSG00000138411 E040 0.2924217 0.0290785164 5.637486e-01   2 196319905 196319925 21 - 0.148 0.000 -11.588
ENSG00000138411 E041 3.4625602 0.0103244797 4.974951e-01 6.340540e-01 2 196320339 196320439 101 - 0.649 0.557 -0.411
ENSG00000138411 E042 5.0050940 0.0118914574 1.861438e-01 3.089122e-01 2 196322478 196322611 134 - 0.799 0.616 -0.759
ENSG00000138411 E043 2.3176144 0.0335982066 1.652948e-01 2.820602e-01 2 196322612 196322620 9 - 0.562 0.310 -1.343
ENSG00000138411 E044 3.6903376 0.0043505861 5.101264e-02 1.109691e-01 2 196324980 196325078 99 - 0.722 0.408 -1.454
ENSG00000138411 E045 1.2598158 0.3075882653 8.605600e-01 9.140705e-01 2 196325079 196325090 12 - 0.348 0.311 -0.228
ENSG00000138411 E046 3.8826486 0.0068042308 9.861585e-01 9.953423e-01 2 196325091 196325149 59 - 0.650 0.667 0.075
ENSG00000138411 E047 4.4224380 0.0037300564 6.540580e-01 7.643567e-01 2 196329575 196329650 76 - 0.669 0.755 0.354
ENSG00000138411 E048 3.6733963 0.0091466493 7.384861e-01 8.283538e-01 2 196334424 196334518 95 - 0.649 0.616 -0.147
ENSG00000138411 E049 2.6541571 0.0059643637 8.532816e-02 1.679341e-01 2 196343657 196343696 40 - 0.608 0.310 -1.553
ENSG00000138411 E050 2.2144863 0.0099864637 1.914455e-01 3.155563e-01 2 196343697 196343764 68 - 0.537 0.310 -1.230
ENSG00000138411 E051 0.1451727 0.0424278351 1.000000e+00   2 196361812 196362222 411 - 0.080 0.000 -10.667
ENSG00000138411 E052 5.0879262 0.0034236899 1.889852e-02 4.911271e-02 2 196433132 196433458 327 - 0.839 0.489 -1.504
ENSG00000138411 E053 0.0000000       2 196493244 196493375 132 -      
ENSG00000138411 E054 0.0000000       2 196586508 196586729 222 -      
ENSG00000138411 E055 0.1472490 0.0430658648 1.000000e+00   2 196592464 196592684 221 - 0.080 0.000 -10.666
ENSG00000138411 E056 0.2924217 0.0290785164 5.637486e-01   2 196592772 196592805 34 - 0.148 0.000 -11.588
ENSG00000138411 E057 1.5479712 0.0091125936 5.051817e-01 6.410173e-01 2 196593508 196593684 177 - 0.420 0.310 -0.647