ENSG00000138398

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000260970 ENSG00000138398 HEK293_OSMI2_2hA HEK293_TMG_2hB PPIG protein_coding protein_coding 39.98381 16.27448 62.27483 0.813245 2.29789 1.935383 3.827720 0.6989374 7.784475 0.1938166 0.1115116 3.458722 0.0784000 0.0444000 0.12536667 0.08096667 8.574214e-03 5.055829e-12 FALSE TRUE
ENST00000409714 ENSG00000138398 HEK293_OSMI2_2hA HEK293_TMG_2hB PPIG protein_coding protein_coding 39.98381 16.27448 62.27483 0.813245 2.29789 1.935383 14.299376 7.8677842 19.972740 0.7545506 1.6892079 1.342893 0.3850708 0.4827333 0.31956667 -0.16316667 5.419196e-03 5.055829e-12 FALSE TRUE
ENST00000417938 ENSG00000138398 HEK293_OSMI2_2hA HEK293_TMG_2hB PPIG protein_coding nonsense_mediated_decay 39.98381 16.27448 62.27483 0.813245 2.29789 1.935383 2.206306 0.0000000 4.647164 0.0000000 0.8335068 8.863308 0.0484625 0.0000000 0.07526667 0.07526667 5.055829e-12 5.055829e-12 FALSE FALSE
ENST00000482772 ENSG00000138398 HEK293_OSMI2_2hA HEK293_TMG_2hB PPIG protein_coding nonsense_mediated_decay 39.98381 16.27448 62.27483 0.813245 2.29789 1.935383 6.094377 3.4258355 8.097860 0.6573009 0.1977168 1.238660 0.1839000 0.2133667 0.13020000 -0.08316667 3.100225e-01 5.055829e-12 FALSE TRUE
ENST00000530152 ENSG00000138398 HEK293_OSMI2_2hA HEK293_TMG_2hB PPIG protein_coding processed_transcript 39.98381 16.27448 62.27483 0.813245 2.29789 1.935383 2.857579 0.2514437 5.001118 0.2514437 0.6235245 4.260560 0.0512750 0.0149000 0.08006667 0.06516667 1.009287e-01 5.055829e-12 FALSE FALSE
MSTRG.19449.19 ENSG00000138398 HEK293_OSMI2_2hA HEK293_TMG_2hB PPIG protein_coding   39.98381 16.27448 62.27483 0.813245 2.29789 1.935383 8.484615 2.9018081 13.865028 0.4407725 0.1334566 2.252503 0.1964417 0.1764667 0.22323333 0.04676667 2.977571e-01 5.055829e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000138398 E001 0.0000000       2 169583779 169584239 461 +      
ENSG00000138398 E002 0.0000000       2 169584240 169584294 55 +      
ENSG00000138398 E003 0.2987644 0.0295318997 1.000000e+00   2 169584295 169584341 47 + 0.128 0.000 -8.723
ENSG00000138398 E004 0.2987644 0.0295318997 1.000000e+00   2 169584342 169584343 2 + 0.128 0.000 -10.614
ENSG00000138398 E005 0.7406253 0.0153856479 2.548906e-01 3.916703e-01 2 169584344 169584350 7 + 0.269 0.000 -12.178
ENSG00000138398 E006 1.0330470 0.0117897117 1.332978e-01 2.387097e-01 2 169584351 169584352 2 + 0.343 0.000 -12.748
ENSG00000138398 E007 4.9101590 0.0049373324 4.033598e-01 5.471328e-01 2 169584353 169584357 5 + 0.751 0.611 -0.586
ENSG00000138398 E008 8.0760205 0.0022342017 1.218132e-01 2.225032e-01 2 169584358 169584366 9 + 0.949 0.726 -0.869
ENSG00000138398 E009 8.2974657 0.0022029097 2.134131e-01 3.425502e-01 2 169584367 169584368 2 + 0.949 0.774 -0.676
ENSG00000138398 E010 19.8328257 0.0011690760 7.915216e-02 1.581582e-01 2 169584369 169584386 18 + 1.298 1.125 -0.612
ENSG00000138398 E011 41.6631892 0.0103442614 3.326248e-01 4.763022e-01 2 169584387 169584431 45 + 1.590 1.504 -0.292
ENSG00000138398 E012 66.8627007 0.0069635634 6.552399e-01 7.651763e-01 2 169584432 169584490 59 + 1.779 1.744 -0.118
ENSG00000138398 E013 0.2966881 0.0290785164 1.000000e+00   2 169584491 169584497 7 + 0.128 0.000 -10.620
ENSG00000138398 E014 0.0000000       2 169584565 169584567 3 +      
ENSG00000138398 E015 2.5539351 0.0065627905 7.840838e-01 8.614982e-01 2 169584568 169584646 79 + 0.509 0.455 -0.267
ENSG00000138398 E016 6.8062083 0.0154062049 3.177202e-01 4.606066e-01 2 169584647 169584799 153 + 0.789 0.927 0.532
ENSG00000138398 E017 17.3100920 0.0080278796 9.738682e-01 9.877116e-01 2 169584800 169584899 100 + 1.202 1.200 -0.007
ENSG00000138398 E018 0.8438645 0.0143037533 6.591104e-02 1.365571e-01 2 169592651 169592739 89 + 0.128 0.455 2.432
ENSG00000138398 E019 84.3448479 0.0006926272 7.670533e-01 8.493892e-01 2 169603642 169603694 53 + 1.873 1.854 -0.064
ENSG00000138398 E020 0.0000000       2 169603695 169604025 331 +      
ENSG00000138398 E021 66.8611736 0.0013055001 1.084711e-01 2.032896e-01 2 169604026 169604031 6 + 1.790 1.697 -0.315
ENSG00000138398 E022 77.5226032 0.0023654421 1.104663e-01 2.062230e-01 2 169604032 169604039 8 + 1.854 1.762 -0.310
ENSG00000138398 E023 132.3483358 0.0002625514 6.009513e-03 1.863587e-02 2 169604040 169604102 63 + 2.086 1.977 -0.366
ENSG00000138398 E024 176.3904219 0.0006720785 1.450680e-05 9.282810e-05 2 169604187 169604261 75 + 2.219 2.062 -0.527
ENSG00000138398 E025 186.2585300 0.0003275958 2.326544e-04 1.102692e-03 2 169606039 169606102 64 + 2.237 2.112 -0.418
ENSG00000138398 E026 179.0329376 0.0002023974 7.936621e-06 5.394744e-05 2 169606103 169606146 44 + 2.226 2.073 -0.512
ENSG00000138398 E027 191.1180621 0.0001963473 6.331496e-05 3.476359e-04 2 169607104 169607148 45 + 2.250 2.118 -0.442
ENSG00000138398 E028 215.7277473 0.0001957384 4.674625e-03 1.502483e-02 2 169608671 169608758 88 + 2.294 2.206 -0.294
ENSG00000138398 E029 2.3102395 0.0208968317 8.920805e-01 9.350713e-01 2 169608759 169611222 2464 + 0.485 0.455 -0.151
ENSG00000138398 E030 0.7437457 0.0157353560 9.621194e-01 9.801025e-01 2 169614402 169614463 62 + 0.227 0.209 -0.155
ENSG00000138398 E031 135.1681595 0.0017231362 4.261258e-02 9.583694e-02 2 169614464 169614493 30 + 2.093 2.005 -0.297
ENSG00000138398 E032 217.5653676 0.0007649493 4.311428e-01 5.737315e-01 2 169614585 169614724 140 + 2.285 2.257 -0.095
ENSG00000138398 E033 156.8602085 0.0002007985 7.693460e-01 8.510221e-01 2 169630774 169630831 58 + 2.135 2.140 0.016
ENSG00000138398 E034 107.9222322 0.0003978219 6.650067e-01 7.727249e-01 2 169630832 169630849 18 + 1.973 1.985 0.041
ENSG00000138398 E035 212.7629538 0.0007517368 5.600810e-01 6.881132e-01 2 169630850 169630987 138 + 2.265 2.277 0.041
ENSG00000138398 E036 9.7086807 0.0019691011 9.110447e-01 9.474999e-01 2 169630988 169631436 449 + 0.973 0.956 -0.067
ENSG00000138398 E037 4.6017143 0.1665345053 6.718711e-01 7.780098e-01 2 169631437 169631598 162 + 0.678 0.734 0.232
ENSG00000138398 E038 4.6970322 0.1940727554 4.423264e-01 5.839637e-01 2 169631599 169631647 49 + 0.751 0.539 -0.915
ENSG00000138398 E039 7.7812169 0.0758428185 7.496659e-01 8.365550e-01 2 169631648 169631765 118 + 0.876 0.926 0.188
ENSG00000138398 E040 106.4813878 0.0018438093 7.977233e-01 8.709495e-01 2 169631766 169631774 9 + 1.967 1.972 0.019
ENSG00000138398 E041 271.7545181 0.0001678882 2.187551e-01 3.489189e-01 2 169631775 169631933 159 + 2.368 2.393 0.085
ENSG00000138398 E042 215.3033850 0.0002208207 7.721245e-01 8.529149e-01 2 169633160 169633247 88 + 2.274 2.277 0.011
ENSG00000138398 E043 1.9123964 0.0081316855 1.840368e-02 4.801842e-02 2 169633248 169633557 310 + 0.269 0.673 2.112
ENSG00000138398 E044 217.1909248 0.0001800050 5.673736e-01 6.942064e-01 2 169636092 169636162 71 + 2.282 2.261 -0.071
ENSG00000138398 E045 229.9614475 0.0002011671 9.732545e-01 9.873091e-01 2 169636163 169636228 66 + 2.304 2.298 -0.020
ENSG00000138398 E046 0.9619567 0.3095726416 8.874931e-01 9.320763e-01 2 169636229 169636412 184 + 0.269 0.212 -0.446
ENSG00000138398 E047 1133.3957289 0.0002744921 9.755171e-36 2.490684e-33 2 169636413 169637523 1111 + 2.951 3.096 0.481
ENSG00000138398 E048 103.5614154 0.0016610460 1.381426e-18 7.474140e-17 2 169637524 169637716 193 + 1.841 2.193 1.180
ENSG00000138398 E049 384.9349747 0.0100373036 3.002813e-06 2.246471e-05 2 169637717 169641406 3690 + 2.575 2.330 -0.817