ENSG00000138386

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000337386 ENSG00000138386 HEK293_OSMI2_2hA HEK293_TMG_2hB NAB1 protein_coding protein_coding 6.227528 1.918158 10.43718 0.3252316 0.4436426 2.437819 0.7121131 0.5221120 0.95773723 0.2727910 0.49733031 0.8628854 0.13075000 0.31406667 0.095033333 -0.21903333 0.7794002774 0.0006291434 FALSE TRUE
ENST00000409581 ENSG00000138386 HEK293_OSMI2_2hA HEK293_TMG_2hB NAB1 protein_coding protein_coding 6.227528 1.918158 10.43718 0.3252316 0.4436426 2.437819 1.5559861 0.3564105 3.07386225 0.3564105 0.31715562 3.0732055 0.21164583 0.14976667 0.292966667 0.14320000 0.3243033915 0.0006291434 FALSE TRUE
ENST00000409641 ENSG00000138386 HEK293_OSMI2_2hA HEK293_TMG_2hB NAB1 protein_coding protein_coding 6.227528 1.918158 10.43718 0.3252316 0.4436426 2.437819 0.4099151 0.1801236 0.09040285 0.1801236 0.09040285 -0.9211377 0.09647083 0.13960000 0.008266667 -0.13133333 0.8197288278 0.0006291434 FALSE TRUE
ENST00000426601 ENSG00000138386 HEK293_OSMI2_2hA HEK293_TMG_2hB NAB1 protein_coding protein_coding 6.227528 1.918158 10.43718 0.3252316 0.4436426 2.437819 0.4397160 0.0000000 0.74841089 0.0000000 0.15023011 6.2449078 0.04797083 0.00000000 0.070700000 0.07070000 0.0007118550 0.0006291434 FALSE FALSE
ENST00000434473 ENSG00000138386 HEK293_OSMI2_2hA HEK293_TMG_2hB NAB1 protein_coding protein_coding 6.227528 1.918158 10.43718 0.3252316 0.4436426 2.437819 0.8555697 0.6450913 1.22242634 0.3379436 0.30907689 0.9117334 0.17491250 0.28683333 0.115300000 -0.17153333 0.7492908466 0.0006291434 FALSE TRUE
MSTRG.19676.10 ENSG00000138386 HEK293_OSMI2_2hA HEK293_TMG_2hB NAB1 protein_coding   6.227528 1.918158 10.43718 0.3252316 0.4436426 2.437819 1.0632916 0.1237752 1.72389113 0.1237752 0.44758540 3.6961313 0.16421250 0.05936667 0.169466667 0.11010000 0.3238720166 0.0006291434 FALSE TRUE
MSTRG.19676.2 ENSG00000138386 HEK293_OSMI2_2hA HEK293_TMG_2hB NAB1 protein_coding   6.227528 1.918158 10.43718 0.3252316 0.4436426 2.437819 0.1692297 0.0000000 0.54433917 0.0000000 0.44636080 5.7926971 0.02290417 0.00000000 0.051033333 0.05103333 0.6148854136 0.0006291434 FALSE FALSE
MSTRG.19676.9 ENSG00000138386 HEK293_OSMI2_2hA HEK293_TMG_2hB NAB1 protein_coding   6.227528 1.918158 10.43718 0.3252316 0.4436426 2.437819 0.2741736 0.0000000 1.04543754 0.0000000 0.30765331 6.7216974 0.04717083 0.00000000 0.099200000 0.09920000 0.0006291434 0.0006291434 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000138386 E001 0.0000000       2 190646746 190646858 113 +      
ENSG00000138386 E002 1.5447238 0.0628375671 5.430489e-01 6.737062e-01 2 190648876 190648894 19 + 0.359 0.242 -0.786
ENSG00000138386 E003 1.5447238 0.0628375671 5.430489e-01 6.737062e-01 2 190648895 190648897 3 + 0.359 0.242 -0.786
ENSG00000138386 E004 1.9843946 0.1400831439 4.008861e-01 5.445622e-01 2 190648898 190648914 17 + 0.433 0.243 -1.191
ENSG00000138386 E005 2.2831590 0.0952623996 2.833372e-01 4.234167e-01 2 190648915 190648958 44 + 0.477 0.242 -1.419
ENSG00000138386 E006 1.1113958 0.0121641437 8.493811e-01 9.065147e-01 2 190648959 190648971 13 + 0.269 0.241 -0.208
ENSG00000138386 E007 0.0000000       2 190649070 190649082 13 +      
ENSG00000138386 E008 4.0330221 0.0040345023 7.280011e-01 8.205377e-01 2 190649083 190649217 135 + 0.632 0.598 -0.148
ENSG00000138386 E009 12.0847716 0.0030129468 1.374974e-01 2.446050e-01 2 190649218 190649360 143 + 1.047 0.885 -0.604
ENSG00000138386 E010 2.8675896 0.0471143933 4.605830e-01 6.005844e-01 2 190649831 190649845 15 + 0.536 0.394 -0.717
ENSG00000138386 E011 6.4672572 0.0280066371 4.031800e-01 5.469692e-01 2 190649846 190649872 27 + 0.799 0.674 -0.510
ENSG00000138386 E012 12.6559700 0.0014565025 2.040212e-01 3.312071e-01 2 190649873 190649982 110 + 1.052 0.925 -0.471
ENSG00000138386 E013 1.3593724 0.5913977788 4.703846e-01 6.096028e-01 2 190653725 190653726 2 + 0.362 0.000 -10.391
ENSG00000138386 E014 2.0851221 0.0078355907 4.227382e-02 9.522837e-02 2 190653727 190653730 4 + 0.477 0.000 -11.933
ENSG00000138386 E015 2.0851221 0.0078355907 4.227382e-02 9.522837e-02 2 190653731 190653738 8 + 0.477 0.000 -11.933
ENSG00000138386 E016 3.1838325 0.0048638854 8.210485e-02 1.628455e-01 2 190653739 190653780 42 + 0.586 0.241 -1.945
ENSG00000138386 E017 13.6539925 0.0014105130 4.954281e-01 6.322277e-01 2 190655977 190656153 177 + 1.074 1.027 -0.171
ENSG00000138386 E018 1.0716550 0.0127520974 8.505028e-01 9.072468e-01 2 190656154 190656159 6 + 0.269 0.241 -0.209
ENSG00000138386 E019 0.8232405 0.0997587979 8.654909e-01 9.173412e-01 2 190659059 190659157 99 + 0.197 0.242 0.384
ENSG00000138386 E020 28.6060724 0.0007052135 1.385706e-01 2.461166e-01 2 190659158 190659276 119 + 1.383 1.291 -0.320
ENSG00000138386 E021 87.3547897 0.0003259046 5.557496e-03 1.743939e-02 2 190659277 190659829 553 + 1.858 1.759 -0.336
ENSG00000138386 E022 24.6304010 0.0093532360 5.268531e-02 1.139314e-01 2 190659830 190659856 27 + 1.334 1.158 -0.621
ENSG00000138386 E023 44.4473500 0.0016818873 1.233540e-02 3.433846e-02 2 190659857 190659995 139 + 1.578 1.431 -0.506
ENSG00000138386 E024 41.7764112 0.0005588415 4.666904e-01 6.062459e-01 2 190670326 190670459 134 + 1.531 1.517 -0.050
ENSG00000138386 E025 26.5252016 0.0037607480 5.467104e-01 6.768265e-01 2 190673101 190673152 52 + 1.342 1.323 -0.068
ENSG00000138386 E026 30.6203116 0.0006926108 9.341883e-01 9.625210e-01 2 190683738 190683827 90 + 1.390 1.419 0.098
ENSG00000138386 E027 19.5848906 0.0009446579 6.080853e-01 7.279334e-01 2 190685476 190685478 3 + 1.215 1.199 -0.057
ENSG00000138386 E028 57.8577857 0.0005552429 3.905026e-01 5.344686e-01 2 190685479 190685638 160 + 1.665 1.651 -0.049
ENSG00000138386 E029 48.5556383 0.0012405215 5.587727e-01 6.869690e-01 2 190687201 190687317 117 + 1.591 1.589 -0.006
ENSG00000138386 E030 307.0405189 0.0040202067 3.815930e-08 4.210837e-07 2 190690245 190692766 2522 + 2.343 2.522 0.598