ENSG00000138380

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000320443 ENSG00000138380 HEK293_OSMI2_2hA HEK293_TMG_2hB CARF protein_coding protein_coding 0.8671362 0.1120113 2.107923 0.006510753 0.2412563 4.117563 0.03075222 0.02468119 0.00000000 0.024681192 0.00000000 -1.794153 0.046212500 0.1978333 0.00000000 -0.19783333 0.1977598512 0.0001989997 FALSE TRUE
ENST00000402905 ENSG00000138380 HEK293_OSMI2_2hA HEK293_TMG_2hB CARF protein_coding protein_coding 0.8671362 0.1120113 2.107923 0.006510753 0.2412563 4.117563 0.10371629 0.02283682 0.08605106 0.022836815 0.08605106 1.548487 0.185687500 0.2115667 0.05110000 -0.16046667 0.6282358057 0.0001989997 FALSE TRUE
ENST00000414439 ENSG00000138380 HEK293_OSMI2_2hA HEK293_TMG_2hB CARF protein_coding protein_coding 0.8671362 0.1120113 2.107923 0.006510753 0.2412563 4.117563 0.03988789 0.00000000 0.15883014 0.000000000 0.10667169 4.077501 0.065100000 0.0000000 0.07956667 0.07956667 0.9595171336 0.0001989997 FALSE TRUE
ENST00000422368 ENSG00000138380 HEK293_OSMI2_2hA HEK293_TMG_2hB CARF protein_coding nonsense_mediated_decay 0.8671362 0.1120113 2.107923 0.006510753 0.2412563 4.117563 0.12776272 0.00000000 0.29107248 0.000000000 0.15202135 4.912039 0.076570833 0.0000000 0.12826667 0.12826667 0.7927652937 0.0001989997 TRUE TRUE
ENST00000427712 ENSG00000138380 HEK293_OSMI2_2hA HEK293_TMG_2hB CARF protein_coding nonsense_mediated_decay 0.8671362 0.1120113 2.107923 0.006510753 0.2412563 4.117563 0.05767614 0.00000000 0.07367476 0.000000000 0.07367476 3.064792 0.060112500 0.0000000 0.03473333 0.03473333 0.8983046780 0.0001989997 FALSE FALSE
ENST00000428585 ENSG00000138380 HEK293_OSMI2_2hA HEK293_TMG_2hB CARF protein_coding protein_coding 0.8671362 0.1120113 2.107923 0.006510753 0.2412563 4.117563 0.02104894 0.00000000 0.15318275 0.000000000 0.15318275 4.028417 0.008620833 0.0000000 0.06080000 0.06080000 0.9215888104 0.0001989997 FALSE TRUE
ENST00000430899 ENSG00000138380 HEK293_OSMI2_2hA HEK293_TMG_2hB CARF protein_coding protein_coding 0.8671362 0.1120113 2.107923 0.006510753 0.2412563 4.117563 0.02941910 0.00000000 0.19565216 0.000000000 0.09892360 4.362134 0.020837500 0.0000000 0.09860000 0.09860000 0.8673244728 0.0001989997   FALSE
ENST00000432024 ENSG00000138380 HEK293_OSMI2_2hA HEK293_TMG_2hB CARF protein_coding protein_coding 0.8671362 0.1120113 2.107923 0.006510753 0.2412563 4.117563 0.03664410 0.00000000 0.15690725 0.000000000 0.15690725 4.060975 0.016941667 0.0000000 0.07396667 0.07396667 0.9104780959 0.0001989997 FALSE FALSE
ENST00000434998 ENSG00000138380 HEK293_OSMI2_2hA HEK293_TMG_2hB CARF protein_coding protein_coding 0.8671362 0.1120113 2.107923 0.006510753 0.2412563 4.117563 0.02588998 0.03153752 0.00000000 0.006882886 0.00000000 -2.054415 0.076070833 0.2841000 0.00000000 -0.28410000 0.0001989997 0.0001989997 FALSE TRUE
ENST00000438828 ENSG00000138380 HEK293_OSMI2_2hA HEK293_TMG_2hB CARF protein_coding protein_coding 0.8671362 0.1120113 2.107923 0.006510753 0.2412563 4.117563 0.09010481 0.03295581 0.12495930 0.014023739 0.04708841 1.651599 0.213945833 0.3065000 0.06460000 -0.24190000 0.0830533486 0.0001989997 FALSE TRUE
ENST00000443740 ENSG00000138380 HEK293_OSMI2_2hA HEK293_TMG_2hB CARF protein_coding protein_coding 0.8671362 0.1120113 2.107923 0.006510753 0.2412563 4.117563 0.10704026 0.00000000 0.15614051 0.000000000 0.08303764 4.054332 0.058120833 0.0000000 0.08056667 0.08056667 0.9189862760 0.0001989997 FALSE FALSE
ENST00000457031 ENSG00000138380 HEK293_OSMI2_2hA HEK293_TMG_2hB CARF protein_coding nonsense_mediated_decay 0.8671362 0.1120113 2.107923 0.006510753 0.2412563 4.117563 0.04359993 0.00000000 0.14424562 0.000000000 0.14424562 3.947158 0.037954167 0.0000000 0.08566667 0.08566667 0.8969362330 0.0001989997 FALSE TRUE
ENST00000471271 ENSG00000138380 HEK293_OSMI2_2hA HEK293_TMG_2hB CARF protein_coding processed_transcript 0.8671362 0.1120113 2.107923 0.006510753 0.2412563 4.117563 0.05726410 0.00000000 0.34762257 0.000000000 0.23658242 5.160366 0.041933333 0.0000000 0.14406667 0.14406667 0.8106051384 0.0001989997 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000138380 E001 0.1451727 0.0441652382 0.733344824   2 202912214 202912217 4 + 0.048 0.000 -9.673
ENSG00000138380 E002 0.3666179 0.0272063486 0.145880116 0.256067067 2 202912218 202912244 27 + 0.048 0.281 2.961
ENSG00000138380 E003 0.2214452 0.0372255917 0.043534744   2 202912245 202912246 2 + 0.000 0.281 15.421
ENSG00000138380 E004 0.2214452 0.0372255917 0.043534744   2 202912247 202912254 8 + 0.000 0.281 15.421
ENSG00000138380 E005 0.2214452 0.0372255917 0.043534744   2 202912255 202912272 18 + 0.000 0.281 15.421
ENSG00000138380 E006 0.2214452 0.0372255917 0.043534744   2 202912273 202912274 2 + 0.000 0.281 15.421
ENSG00000138380 E007 0.2214452 0.0372255917 0.043534744   2 202912275 202912276 2 + 0.000 0.281 15.421
ENSG00000138380 E008 0.2214452 0.0372255917 0.043534744   2 202912277 202912278 2 + 0.000 0.281 15.421
ENSG00000138380 E009 0.2214452 0.0372255917 0.043534744   2 202912279 202912282 4 + 0.000 0.281 15.421
ENSG00000138380 E010 0.2214452 0.0372255917 0.043534744   2 202912283 202912283 1 + 0.000 0.281 15.421
ENSG00000138380 E011 0.5138669 0.0221888199 0.290435332 0.431241495 2 202912284 202912285 2 + 0.091 0.281 1.960
ENSG00000138380 E012 0.6611159 0.0198259979 0.438831433 0.580668292 2 202912286 202912288 3 + 0.130 0.281 1.375
ENSG00000138380 E013 0.8083650 0.1302024407 0.587946750 0.711191939 2 202912289 202912291 3 + 0.166 0.282 0.973
ENSG00000138380 E014 2.1830508 0.0088425450 0.775357254 0.855286390 2 202912292 202912324 33 + 0.380 0.450 0.374
ENSG00000138380 E015 1.2889475 0.0104766185 0.301923715 0.443753865 2 202912325 202913033 709 + 0.231 0.450 1.374
ENSG00000138380 E016 1.6909538 0.0097567333 0.536011572 0.667800764 2 202913034 202913102 69 + 0.312 0.449 0.788
ENSG00000138380 E017 0.6256415 0.0181112396 0.437647766 0.579558478 2 202913103 202913114 12 + 0.130 0.280 1.373
ENSG00000138380 E018 5.6753410 0.0033672326 0.036280203 0.084120819 2 202917877 202918043 167 + 0.726 0.280 -2.252
ENSG00000138380 E019 0.8984834 0.0169737913 0.523785238 0.657419219 2 202924297 202924356 60 + 0.231 0.000 -13.986
ENSG00000138380 E020 1.1856066 0.0112353997 0.975468439 0.988683312 2 202924357 202924415 59 + 0.259 0.280 0.149
ENSG00000138380 E021 0.4375944 0.0286272976 1.000000000 1.000000000 2 202934502 202934599 98 + 0.130 0.000 -13.326
ENSG00000138380 E022 0.0000000       2 202938274 202938395 122 +      
ENSG00000138380 E023 3.5419322 0.0045596008 0.186938553 0.309884222 2 202941860 202941980 121 + 0.566 0.280 -1.566
ENSG00000138380 E024 2.2133430 0.0069263191 0.102829076 0.194796213 2 202942740 202942762 23 + 0.440 0.000 -14.748
ENSG00000138380 E025 6.2976215 0.0033204510 0.022356175 0.056421154 2 202942763 202942967 205 + 0.762 0.280 -2.399
ENSG00000138380 E026 6.2683760 0.0096765512 0.024401611 0.060646132 2 202952559 202952679 121 + 0.763 0.280 -2.400
ENSG00000138380 E027 7.5144492 0.0029699339 0.047800923 0.105266270 2 202954005 202954134 130 + 0.820 0.449 -1.627
ENSG00000138380 E028 4.8477178 0.0034119446 0.661004575 0.769562206 2 202955674 202955758 85 + 0.642 0.571 -0.315
ENSG00000138380 E029 5.8536077 0.0033383997 0.836012379 0.897459584 2 202961237 202961426 190 + 0.696 0.743 0.191
ENSG00000138380 E030 2.2927480 0.0099387402 0.115920878 0.214125855 2 202961427 202963168 1742 + 0.359 0.665 1.497
ENSG00000138380 E031 4.0103218 0.0454630463 0.488557194 0.626095480 2 202966978 202967098 121 + 0.594 0.448 -0.695
ENSG00000138380 E032 4.7038168 0.0313026500 0.839045058 0.899415321 2 202969919 202970062 144 + 0.618 0.665 0.201
ENSG00000138380 E033 5.6177168 0.0668257880 0.222305070 0.353159936 2 202971505 202971738 234 + 0.716 0.447 -1.223
ENSG00000138380 E034 0.4470576 0.0234978824 0.289988337 0.430749970 2 202973482 202973584 103 + 0.091 0.280 1.956
ENSG00000138380 E035 4.0464747 0.1308767989 0.997316707 1.000000000 2 202974334 202974496 163 + 0.579 0.569 -0.045
ENSG00000138380 E036 2.6154604 0.0071221374 0.477764575 0.616266531 2 202977269 202977332 64 + 0.421 0.571 0.736
ENSG00000138380 E037 4.6867392 0.0037421535 0.314833721 0.457580949 2 202981555 202981685 131 + 0.642 0.449 -0.900
ENSG00000138380 E038 7.1208620 0.0033724759 0.065663133 0.136153709 2 202982072 202982441 370 + 0.796 0.449 -1.533
ENSG00000138380 E039 28.8310229 0.0007386411 0.001336308 0.005097549 2 202983506 202988263 4758 + 1.273 1.515 0.839