ENSG00000138376

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000260947 ENSG00000138376 HEK293_OSMI2_2hA HEK293_TMG_2hB BARD1 protein_coding protein_coding 6.505006 1.200357 10.18453 0.2444582 0.5759913 3.074291 3.3885328 1.136091 5.7037472 0.2384362 0.2365025 2.317715 0.69176250 0.9459 0.56110000 -0.38480000 1.779452e-11 1.779452e-11 FALSE TRUE
ENST00000455743 ENSG00000138376 HEK293_OSMI2_2hA HEK293_TMG_2hB BARD1 protein_coding nonsense_mediated_decay 6.505006 1.200357 10.18453 0.2444582 0.5759913 3.074291 0.6319139 0.000000 0.5909610 0.0000000 0.3161553 5.909199 0.06145833 0.0000 0.06100000 0.06100000 5.862838e-01 1.779452e-11 FALSE TRUE
ENST00000617164 ENSG00000138376 HEK293_OSMI2_2hA HEK293_TMG_2hB BARD1 protein_coding protein_coding 6.505006 1.200357 10.18453 0.2444582 0.5759913 3.074291 1.1271351 0.000000 2.4593917 0.0000000 0.2599521 7.948012 0.09729167 0.0000 0.24270000 0.24270000 7.907833e-08 1.779452e-11 FALSE TRUE
ENST00000620057 ENSG00000138376 HEK293_OSMI2_2hA HEK293_TMG_2hB BARD1 protein_coding protein_coding 6.505006 1.200357 10.18453 0.2444582 0.5759913 3.074291 0.2436390 0.000000 0.6488335 0.0000000 0.3477008 6.041842 0.03415833 0.0000 0.06053333 0.06053333 5.640209e-01 1.779452e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000138376 E001 242.6895594 0.0409829145 2.666708e-08 3.032776e-07 2 214725646 214728423 2778 - 2.049 2.653 2.016
ENSG00000138376 E002 29.1875337 0.0007142401 5.242978e-01 6.578664e-01 2 214728424 214728537 114 - 1.233 1.486 0.881
ENSG00000138376 E003 14.0083197 0.0013013573 8.791839e-01 9.264061e-01 2 214728538 214728552 15 - 0.945 1.152 0.756
ENSG00000138376 E004 10.6407963 0.0016123080 2.919942e-01 4.329316e-01 2 214728553 214728561 9 - 0.861 0.880 0.073
ENSG00000138376 E005 10.7827467 0.0016806750 4.810638e-01 6.193078e-01 2 214728562 214728570 9 - 0.861 0.939 0.296
ENSG00000138376 E006 16.4482953 0.0010491415 1.574409e-01 2.717045e-01 2 214728571 214728584 14 - 1.031 1.037 0.022
ENSG00000138376 E007 30.6575474 0.0008877646 2.358026e-01 3.693282e-01 2 214728585 214728674 90 - 1.275 1.361 0.301
ENSG00000138376 E008 17.0768047 0.0083134889 1.414893e-01 2.500577e-01 2 214728675 214728675 1 - 1.046 1.037 -0.035
ENSG00000138376 E009 17.2283201 0.0074820258 1.311829e-01 2.358028e-01 2 214728676 214728676 1 - 1.050 1.037 -0.048
ENSG00000138376 E010 20.9497771 0.0096722620 4.447960e-01 5.863484e-01 2 214728677 214728703 27 - 1.116 1.214 0.352
ENSG00000138376 E011 61.6122736 0.0005406280 2.436706e-01 3.784941e-01 2 214728704 214729008 305 - 1.558 1.683 0.425
ENSG00000138376 E012 1.0330470 0.0118666115 4.160976e-01 5.594638e-01 2 214730235 214730280 46 - 0.224 0.000 -9.893
ENSG00000138376 E013 38.2160442 0.0515614647 3.580038e-01 5.023981e-01 2 214730411 214730508 98 - 1.365 1.421 0.192
ENSG00000138376 E014 0.0000000       2 214730908 214731145 238 -      
ENSG00000138376 E015 31.5964047 0.0006748681 2.829190e-03 9.761624e-03 2 214745067 214745159 93 - 1.301 1.184 -0.410
ENSG00000138376 E016 0.1451727 0.0442203529 7.719207e-01   2 214745712 214745721 10 - 0.040 0.000 -7.085
ENSG00000138376 E017 38.3431371 0.0007072392 1.873164e-04 9.093697e-04 2 214745722 214745854 133 - 1.386 1.214 -0.600
ENSG00000138376 E018 35.2852461 0.0006313107 5.203193e-03 1.648325e-02 2 214752447 214752555 109 - 1.343 1.269 -0.257
ENSG00000138376 E019 49.5373257 0.0004928085 1.148516e-03 4.466262e-03 2 214767482 214767654 173 - 1.486 1.419 -0.228
ENSG00000138376 E020 32.8733683 0.0006560429 2.022067e-07 1.935697e-06 2 214769232 214769312 81 - 1.337 0.880 -1.652
ENSG00000138376 E021 1.1866387 0.0108633720 3.377380e-01 4.816369e-01 2 214769313 214770845 1533 - 0.248 0.000 -10.086
ENSG00000138376 E022 62.0707381 0.0004191509 1.077313e-03 4.225805e-03 2 214780560 214780896 337 - 1.578 1.545 -0.112
ENSG00000138376 E023 25.2850755 0.0009717996 9.938084e-02 1.895435e-01 2 214780897 214780967 71 - 1.197 1.214 0.061
ENSG00000138376 E024 84.3963063 0.0014063088 1.394022e-07 1.377710e-06 2 214780968 214781509 542 - 1.717 1.558 -0.541
ENSG00000138376 E025 32.4561573 0.0005871514 5.724534e-06 4.020672e-05 2 214792297 214792445 149 - 1.327 0.991 -1.203
ENSG00000138376 E026 1.4769841 0.0089488799 2.305278e-01 3.630897e-01 2 214796794 214797060 267 - 0.293 0.000 -10.407
ENSG00000138376 E027 19.7858980 0.0009799920 1.273465e-04 6.471583e-04 2 214797061 214797117 57 - 1.125 0.732 -1.489
ENSG00000138376 E028 28.1899138 0.1173686443 1.712068e-01 2.897578e-01 2 214809412 214809683 272 - 1.249 1.170 -0.280