ENSG00000138375

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000357276 ENSG00000138375 HEK293_OSMI2_2hA HEK293_TMG_2hB SMARCAL1 protein_coding protein_coding 16.38478 20.28597 15.13867 1.451242 0.3322409 -0.4220017 8.624309 9.7485606 8.0442124 1.0238779 0.1333157 -0.2769248 0.53254167 0.4799667 0.5315333 0.05156667 5.467553e-01 1.74664e-06 FALSE  
ENST00000358207 ENSG00000138375 HEK293_OSMI2_2hA HEK293_TMG_2hB SMARCAL1 protein_coding protein_coding 16.38478 20.28597 15.13867 1.451242 0.3322409 -0.4220017 4.474164 6.3583485 3.7581197 0.5085677 0.1434437 -0.7570745 0.26723333 0.3144000 0.2488667 -0.06553333 2.523252e-01 1.74664e-06 FALSE  
ENST00000392128 ENSG00000138375 HEK293_OSMI2_2hA HEK293_TMG_2hB SMARCAL1 protein_coding protein_coding 16.38478 20.28597 15.13867 1.451242 0.3322409 -0.4220017 1.122147 2.3247239 0.3808959 0.7981175 0.2103106 -2.5783957 0.06424583 0.1163333 0.0246000 -0.09173333 5.364477e-02 1.74664e-06 FALSE  
ENST00000430374 ENSG00000138375 HEK293_OSMI2_2hA HEK293_TMG_2hB SMARCAL1 protein_coding protein_coding 16.38478 20.28597 15.13867 1.451242 0.3322409 -0.4220017 1.214127 0.6235321 1.9408944 0.1448573 0.1912078 1.6226459 0.07725417 0.0306000 0.1278000 0.09720000 1.746640e-06 1.74664e-06 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000138375 E001 6.7358191 0.0276586439 1.098669e-01 2.053570e-01 2 216412414 216412483 70 + 0.993 0.766 -0.872
ENSG00000138375 E002 15.2540245 0.0313048572 3.017443e-01 4.435555e-01 2 216412484 216412509 26 + 1.261 1.137 -0.440
ENSG00000138375 E003 30.2877614 0.0063867707 6.430547e-02 1.338763e-01 2 216412510 216412560 51 + 1.556 1.415 -0.484
ENSG00000138375 E004 35.5591855 0.0026701123 1.440227e-02 3.913785e-02 2 216412561 216412603 43 + 1.634 1.477 -0.540
ENSG00000138375 E005 36.0660575 0.0039465453 1.038601e-02 2.970991e-02 2 216412604 216412648 45 + 1.647 1.477 -0.582
ENSG00000138375 E006 3.3173955 0.2237948831 8.672732e-01 9.186393e-01 2 216412649 216412717 69 + 0.641 0.588 -0.234
ENSG00000138375 E007 1.7265525 0.1565240398 5.492826e-01 6.790297e-01 2 216412718 216412734 17 + 0.492 0.359 -0.709
ENSG00000138375 E008 0.2966881 0.0273702548 9.680191e-02   2 216412743 216412764 22 + 0.265 0.000 -11.184
ENSG00000138375 E009 8.6168080 0.0020074250 2.652006e-02 6.499038e-02 2 216412765 216412798 34 + 1.107 0.863 -0.906
ENSG00000138375 E010 0.8147077 0.1333742590 8.791989e-02 1.719630e-01 2 216412799 216412936 138 + 0.429 0.098 -2.730
ENSG00000138375 E011 57.3778728 0.0193529087 4.862196e-02 1.067190e-01 2 216413856 216413892 37 + 1.840 1.679 -0.546
ENSG00000138375 E012 2.4130408 0.0470432943 4.229902e-02 9.527219e-02 2 216413893 216414363 471 + 0.717 0.354 -1.742
ENSG00000138375 E013 190.6038608 0.0043548399 1.054669e-05 6.974689e-05 2 216414647 216415007 361 + 2.367 2.190 -0.592
ENSG00000138375 E014 122.3737498 0.0004318155 1.041828e-08 1.279554e-07 2 216415008 216415112 105 + 2.185 1.996 -0.633
ENSG00000138375 E015 235.9164166 0.0002119531 5.504572e-08 5.878698e-07 2 216415113 216415515 403 + 2.431 2.302 -0.430
ENSG00000138375 E016 0.0000000       2 216415945 216416029 85 +      
ENSG00000138375 E017 74.6417677 0.0003254203 4.996862e-01 6.359687e-01 2 216416257 216416307 51 + 1.876 1.845 -0.105
ENSG00000138375 E018 140.2974228 0.0002760517 9.478960e-01 9.712484e-01 2 216420299 216420532 234 + 2.126 2.125 -0.004
ENSG00000138375 E019 73.0353104 0.0006044299 3.216138e-01 4.648744e-01 2 216423633 216423683 51 + 1.876 1.830 -0.153
ENSG00000138375 E020 0.3729606 0.0355794861 7.150857e-01 8.111152e-01 2 216427055 216427445 391 + 0.153 0.098 -0.740
ENSG00000138375 E021 155.7866856 0.0003156272 6.254064e-01 7.415454e-01 2 216428596 216428775 180 + 2.183 2.166 -0.058
ENSG00000138375 E022 73.7563197 0.0033167826 5.343097e-01 6.663772e-01 2 216428776 216428782 7 + 1.873 1.837 -0.120
ENSG00000138375 E023 139.3252244 0.0016226853 4.928496e-01 6.299726e-01 2 216432718 216432868 151 + 2.109 2.129 0.067
ENSG00000138375 E024 140.4854986 0.0002689068 2.238378e-01 3.549966e-01 2 216435338 216435496 159 + 2.103 2.138 0.117
ENSG00000138375 E025 88.0705922 0.0002929282 4.594997e-01 5.996349e-01 2 216438420 216438485 66 + 1.908 1.934 0.088
ENSG00000138375 E026 2.4177687 0.0707131949 9.052523e-01 9.436745e-01 2 216446662 216446718 57 + 0.492 0.517 0.119
ENSG00000138375 E027 119.3849857 0.0002841152 4.969326e-01 6.334990e-01 2 216447018 216447121 104 + 2.043 2.063 0.067
ENSG00000138375 E028 67.3395712 0.0026581716 5.749885e-01 7.007211e-01 2 216447122 216447158 37 + 1.832 1.801 -0.105
ENSG00000138375 E029 177.4888597 0.0004864308 2.165728e-03 7.737392e-03 2 216450846 216451064 219 + 2.171 2.258 0.289
ENSG00000138375 E030 1.8414330 0.2190028488 6.943587e-01 7.952085e-01 2 216451065 216451601 537 + 0.355 0.452 0.532
ENSG00000138375 E031 120.2106328 0.0002577537 4.099786e-04 1.812542e-03 2 216464597 216464667 71 + 1.977 2.096 0.398
ENSG00000138375 E032 134.9485396 0.0002545536 2.971483e-05 1.770303e-04 2 216467944 216468046 103 + 2.016 2.149 0.447
ENSG00000138375 E033 174.0638422 0.0016107586 8.714590e-05 4.616242e-04 2 216475269 216475451 183 + 2.130 2.260 0.434
ENSG00000138375 E034 157.8330546 0.0010260318 5.137055e-05 2.886034e-04 2 216477109 216477209 101 + 2.087 2.218 0.438
ENSG00000138375 E035 164.2321987 0.0012616822 1.484607e-03 5.586716e-03 2 216478203 216478299 97 + 2.124 2.227 0.341
ENSG00000138375 E036 185.2883970 0.0043753809 2.275929e-02 5.724710e-02 2 216482738 216483053 316 + 2.183 2.275 0.305