ENSG00000138363

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000236959 ENSG00000138363 HEK293_OSMI2_2hA HEK293_TMG_2hB ATIC protein_coding protein_coding 183.248 267.5172 158.5088 34.83425 3.829142 -0.7550323 129.08890 164.13479 131.054437 15.77828 4.165502 -0.3246927 0.7238750 0.6220000 0.82650000 0.2045000 1.059764e-03 3.503308e-11 FALSE TRUE
ENST00000479093 ENSG00000138363 HEK293_OSMI2_2hA HEK293_TMG_2hB ATIC protein_coding retained_intron 183.248 267.5172 158.5088 34.83425 3.829142 -0.7550323 36.55808 87.70334 5.465657 25.13015 1.903326 -4.0016923 0.1706833 0.3196667 0.03463333 -0.2850333 1.220281e-06 3.503308e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000138363 E001 1.9218622 0.0100794206 4.523347e-02 1.006205e-01 2 215311956 215311991 36 + 0.630 0.309 -1.653
ENSG00000138363 E002 17.3054262 0.0181943708 5.379008e-01 6.693886e-01 2 215311992 215312058 67 + 1.268 1.222 -0.165
ENSG00000138363 E003 37.7236594 0.0019640478 2.379087e-02 5.938376e-02 2 215312059 215312071 13 + 1.638 1.524 -0.389
ENSG00000138363 E004 241.1617219 0.0063269516 3.191269e-04 1.457443e-03 2 215312072 215312090 19 + 2.454 2.305 -0.496
ENSG00000138363 E005 497.0425268 0.0040255637 5.061905e-05 2.849222e-04 2 215312091 215312129 39 + 2.754 2.629 -0.416
ENSG00000138363 E006 580.6423234 0.0030120805 2.484206e-06 1.893941e-05 2 215312130 215312161 32 + 2.823 2.695 -0.424
ENSG00000138363 E007 13.5492334 0.0012721724 5.160686e-09 6.716656e-08 2 215312162 215312343 182 + 1.406 0.903 -1.806
ENSG00000138363 E008 15.9728982 0.0011643683 1.052449e-04 5.462405e-04 2 215312344 215312390 47 + 1.385 1.085 -1.061
ENSG00000138363 E009 22.4801907 0.0008842208 5.393834e-08 5.772487e-07 2 215312391 215312497 107 + 1.553 1.184 -1.281
ENSG00000138363 E010 1028.9678019 0.0022845006 4.547859e-08 4.946482e-07 2 215312498 215312624 127 + 3.067 2.947 -0.400
ENSG00000138363 E011 1.7285271 0.0081333665 6.207067e-01 7.377936e-01 2 215318131 215318156 26 + 0.347 0.450 0.570
ENSG00000138363 E012 960.0532694 0.0015736382 1.693249e-05 1.067491e-04 2 215318157 215318233 77 + 3.012 2.935 -0.255
ENSG00000138363 E013 924.8037932 0.0018179252 3.970797e-03 1.305999e-02 2 215319665 215319731 67 + 2.978 2.929 -0.165
ENSG00000138363 E014 3.0550373 0.0056764706 9.097279e-01 9.466241e-01 2 215325180 215325240 61 + 0.586 0.586 -0.001
ENSG00000138363 E015 1091.7444268 0.0001317575 1.631795e-09 2.325749e-08 2 215325241 215325329 89 + 3.052 3.004 -0.160
ENSG00000138363 E016 1465.1360199 0.0006283468 1.277435e-04 6.488797e-04 2 215325987 215326138 152 + 3.171 3.133 -0.126
ENSG00000138363 E017 2.1830602 0.0075006368 5.326823e-01 6.650085e-01 2 215326139 215326139 1 + 0.538 0.450 -0.431
ENSG00000138363 E018 1411.0591281 0.0003406348 2.240632e-02 5.652211e-02 2 215326822 215326978 157 + 3.137 3.129 -0.026
ENSG00000138363 E019 1247.5756574 0.0007108251 1.982926e-01 3.240818e-01 2 215332382 215332507 126 + 3.078 3.077 -0.003
ENSG00000138363 E020 1079.7714114 0.0009261589 7.546978e-01 8.402643e-01 2 215333350 215333457 108 + 3.005 3.018 0.043
ENSG00000138363 E021 2.1078304 0.0382340222 7.549458e-01 8.404370e-01 2 215334917 215334918 2 + 0.421 0.489 0.352
ENSG00000138363 E022 1010.6568699 0.0010988771 2.821284e-01 4.220898e-01 2 215334919 215335004 86 + 2.987 2.984 -0.010
ENSG00000138363 E023 0.7310603 0.0677272101 6.640241e-02 1.373964e-01 2 215336022 215336034 13 + 0.420 0.100 -2.657
ENSG00000138363 E024 1143.7671869 0.0017155540 2.006914e-01 3.270626e-01 2 215336035 215336124 90 + 3.008 3.053 0.150
ENSG00000138363 E025 0.0000000       2 215338766 215338768 3 +      
ENSG00000138363 E026 2.5993608 0.0685257806 6.721669e-01 7.782334e-01 2 215338769 215338778 10 + 0.586 0.522 -0.292
ENSG00000138363 E027 1342.5351115 0.0004457841 4.581820e-03 1.476889e-02 2 215338779 215338869 91 + 3.069 3.130 0.200
ENSG00000138363 E028 926.8678681 0.0001679702 4.434892e-05 2.530425e-04 2 215338870 215338907 38 + 2.898 2.977 0.263
ENSG00000138363 E029 1581.9071709 0.0008376610 6.646263e-03 2.030568e-02 2 215344779 215344871 93 + 3.137 3.202 0.216
ENSG00000138363 E030 10.0857162 0.0017003102 6.562860e-07 5.670357e-06 2 215344872 215345587 716 + 1.278 0.792 -1.791
ENSG00000138363 E031 2208.8554189 0.0016135695 1.094136e-04 5.653370e-04 2 215346759 215346941 183 + 3.258 3.355 0.322
ENSG00000138363 E032 50.5992709 0.0106166904 1.952631e-07 1.874911e-06 2 215346942 215347240 299 + 1.888 1.548 -1.153
ENSG00000138363 E033 19.7146594 0.0066300112 9.371614e-08 9.567410e-07 2 215347621 215347652 32 + 1.532 1.109 -1.478
ENSG00000138363 E034 11.0858386 0.0015476941 2.500578e-05 1.516289e-04 2 215348684 215348731 48 + 1.278 0.889 -1.413
ENSG00000138363 E035 14.7077202 0.0012719512 1.628827e-02 4.336252e-02 2 215348985 215349093 109 + 1.296 1.111 -0.655
ENSG00000138363 E036 1947.5429822 0.0041017262 5.870881e-06 4.115363e-05 2 215349094 215349249 156 + 3.156 3.318 0.538
ENSG00000138363 E037 3.8988157 0.0040022306 4.111786e-01 5.547668e-01 2 215349250 215349298 49 + 0.740 0.641 -0.413
ENSG00000138363 E038 1453.3127578 0.0049813402 9.480042e-06 6.336540e-05 2 215349536 215349773 238 + 3.017 3.195 0.591
ENSG00000138363 E039 0.0000000       2 215359068 215359122 55 +