ENSG00000138326

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000372360 ENSG00000138326 HEK293_OSMI2_2hA HEK293_TMG_2hB RPS24 protein_coding protein_coding 3661.203 4873.339 4091.912 226.7756 120.8668 -0.2521349 2150.138 2756.020 2674.463 137.75346 91.66212 -0.04333657 0.5950000 0.5653667 0.6534333 0.08806667 4.659059e-12 5.769634e-19 FALSE TRUE
ENST00000613865 ENSG00000138326 HEK293_OSMI2_2hA HEK293_TMG_2hB RPS24 protein_coding protein_coding 3661.203 4873.339 4091.912 226.7756 120.8668 -0.2521349 1427.947 2061.094 1295.609 87.32455 27.28275 -0.66977529 0.3815167 0.4231333 0.3168333 -0.10630000 5.769634e-19 5.769634e-19 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000138326 E001 4.192079 1.972620e-01 7.860428e-01 8.629812e-01 10 78033752 78033759 8 + 0.680 0.730 0.205
ENSG00000138326 E002 187.924211 2.436535e-03 7.561015e-01 8.412619e-01 10 78033760 78033835 76 + 2.273 2.259 -0.044
ENSG00000138326 E003 606.067485 1.650310e-03 9.189304e-07 7.687049e-06 10 78033836 78033862 27 + 2.690 2.814 0.412
ENSG00000138326 E004 681.420824 1.161768e-03 3.863951e-10 6.179419e-09 10 78033863 78033873 11 + 2.731 2.869 0.459
ENSG00000138326 E005 795.110098 4.956810e-04 8.554176e-13 2.124214e-11 10 78033874 78033876 3 + 2.809 2.931 0.405
ENSG00000138326 E006 8889.304052 5.501713e-04 3.337900e-06 2.474379e-05 10 78033877 78033885 9 + 3.970 3.913 -0.188
ENSG00000138326 E007 11093.380594 2.230574e-04 5.213786e-12 1.137226e-10 10 78033886 78033890 5 + 4.065 4.010 -0.183
ENSG00000138326 E008 15259.410991 1.150410e-04 1.722016e-02 4.543097e-02 10 78033891 78033903 13 + 4.180 4.165 -0.050
ENSG00000138326 E009 15244.222399 1.128040e-04 1.303775e-02 3.599951e-02 10 78033904 78033904 1 + 4.180 4.164 -0.051
ENSG00000138326 E010 21.699929 3.752459e-03 1.001008e-01 1.906314e-01 10 78033905 78033916 12 + 1.415 1.284 -0.457
ENSG00000138326 E011 63.696087 1.977629e-02 5.961610e-02 1.259728e-01 10 78033917 78033986 70 + 1.895 1.731 -0.552
ENSG00000138326 E012 24.736218 7.844345e-04 7.086432e-02 1.447833e-01 10 78033987 78034202 216 + 1.468 1.342 -0.437
ENSG00000138326 E013 1.069477 1.136373e-02 4.404433e-01 5.821211e-01 10 78034203 78034207 5 + 0.401 0.264 -0.855
ENSG00000138326 E014 5.337206 4.902977e-02 1.287973e-02 3.563484e-02 10 78034208 78034209 2 + 1.004 0.606 -1.580
ENSG00000138326 E015 24.555117 3.062367e-02 2.165483e-02 5.496084e-02 10 78034210 78034316 107 + 1.536 1.293 -0.839
ENSG00000138326 E016 42.469498 7.908163e-03 2.183753e-02 5.534002e-02 10 78034317 78034421 105 + 1.720 1.568 -0.518
ENSG00000138326 E017 24037.565176 7.031334e-05 2.589581e-01 3.963006e-01 10 78035352 78035417 66 + 4.372 4.365 -0.022
ENSG00000138326 E018 25353.886962 2.524336e-04 6.200093e-01 7.372887e-01 10 78035511 78035565 55 + 4.390 4.392 0.004
ENSG00000138326 E019 38172.293590 5.060796e-05 1.228839e-29 2.001719e-27 10 78035566 78035720 155 + 4.547 4.582 0.117
ENSG00000138326 E020 119.687041 7.226067e-02 6.332043e-10 9.752737e-09 10 78035721 78036529 809 + 2.411 1.502 -3.062
ENSG00000138326 E021 23617.458130 2.926322e-04 2.031932e-07 1.944551e-06 10 78037194 78037304 111 + 4.336 4.374 0.128
ENSG00000138326 E022 120.959741 1.669592e-02 3.433704e-23 3.110975e-21 10 78037305 78037438 134 + 2.383 1.648 -2.469
ENSG00000138326 E023 52.542252 2.745226e-03 4.408783e-30 7.497582e-28 10 78037439 78037441 3 + 2.003 1.358 -2.193
ENSG00000138326 E024 327.001582 6.353729e-03 2.828427e-67 3.773501e-64 10 78037442 78037964 523 + 2.827 2.020 -2.693
ENSG00000138326 E025 67.883010 1.185699e-03 1.995190e-46 9.920809e-44 10 78037965 78037982 18 + 2.122 1.440 -2.309
ENSG00000138326 E026 72.456189 5.075201e-03 1.620277e-34 3.836958e-32 10 78037983 78037993 11 + 2.153 1.459 -2.346
ENSG00000138326 E027 329.430562 1.571497e-02 8.952580e-24 8.648849e-22 10 78037994 78038555 562 + 2.796 2.135 -2.204
ENSG00000138326 E028 1236.482322 2.730869e-02 1.570725e-12 3.725668e-11 10 78038556 78040200 1645 + 3.342 2.773 -1.894
ENSG00000138326 E029 161.835222 1.938628e-02 1.352543e-04 6.823476e-04 10 78040201 78040203 3 + 2.347 2.080 -0.895
ENSG00000138326 E030 3981.455414 4.044402e-04 1.739871e-03 6.407973e-03 10 78040204 78040225 22 + 3.610 3.573 -0.121
ENSG00000138326 E031 258.933514 3.297260e-02 4.012231e-03 1.317682e-02 10 78040226 78040614 389 + 2.537 2.295 -0.806
ENSG00000138326 E032 8580.599367 5.937697e-04 4.934507e-13 1.271874e-11 10 78040615 78040716 102 + 3.864 3.952 0.290
ENSG00000138326 E033 5.077863 1.943099e-02 8.661322e-01 9.177959e-01 10 78040717 78040747 31 + 0.799 0.778 -0.084
ENSG00000138326 E034 7.781162 5.243907e-02 2.684985e-01 4.069755e-01 10 78048981 78049225 245 + 1.035 0.878 -0.587
ENSG00000138326 E035 46.669427 4.925995e-04 4.741660e-06 3.393243e-05 10 78054531 78056813 2283 + 1.496 1.749 0.862