ENSG00000138286

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000607940 ENSG00000138286 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM149B1 protein_coding processed_transcript 9.624205 6.747897 12.875 0.8320135 1.049484 0.9310459 2.048729 2.091938 2.238068 0.2408079 0.1187947 0.0969658 0.2356875 0.3124667 0.1748333 -0.13763333 0.0008977531 0.0008977531   FALSE
MSTRG.4175.2 ENSG00000138286 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM149B1 protein_coding   9.624205 6.747897 12.875 0.8320135 1.049484 0.9310459 2.366460 1.065136 3.526152 0.1948418 0.6412455 1.7176619 0.2214208 0.1638000 0.2715667 0.10776667 0.2336019168 0.0008977531 FALSE TRUE
MSTRG.4175.4 ENSG00000138286 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM149B1 protein_coding   9.624205 6.747897 12.875 0.8320135 1.049484 0.9310459 3.591229 2.432931 4.853401 0.5228046 0.3535064 0.9933526 0.3739708 0.3536333 0.3784000 0.02476667 0.8811493708 0.0008977531 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000138286 E001 4.7496583 0.2118177877 1.672390e-01 2.846066e-01 10 73168119 73168215 97 + 0.853 0.512 -1.445
ENSG00000138286 E002 4.5626684 0.0726503086 9.386592e-02 1.811724e-01 10 73168216 73168228 13 + 0.837 0.504 -1.422
ENSG00000138286 E003 5.1464651 0.1531753289 3.014966e-01 4.433089e-01 10 73168229 73168245 17 + 0.852 0.618 -0.959
ENSG00000138286 E004 11.1698563 0.0348452360 5.203618e-02 1.127791e-01 10 73168246 73168347 102 + 1.166 0.880 -1.055
ENSG00000138286 E005 26.1622994 0.0113315027 5.121408e-03 1.625912e-02 10 73168348 73168386 39 + 1.515 1.253 -0.908
ENSG00000138286 E006 43.5619979 0.0070096267 6.155728e-05 3.391352e-04 10 73174687 73174791 105 + 1.738 1.445 -1.000
ENSG00000138286 E007 31.3070209 0.0006491338 9.758006e-05 5.106840e-04 10 73177846 73177871 26 + 1.595 1.330 -0.913
ENSG00000138286 E008 49.7857530 0.0126084901 2.668644e-03 9.278325e-03 10 73177872 73177973 102 + 1.784 1.539 -0.830
ENSG00000138286 E009 15.3203487 0.0071714668 2.248694e-01 3.562746e-01 10 73177974 73177975 2 + 1.258 1.132 -0.447
ENSG00000138286 E010 63.3439160 0.0108412620 4.358721e-01 5.780208e-01 10 73192556 73192698 143 + 1.830 1.768 -0.208
ENSG00000138286 E011 51.8641822 0.0006922443 5.129869e-01 6.478495e-01 10 73193477 73193593 117 + 1.712 1.738 0.086
ENSG00000138286 E012 36.5549113 0.0011944975 8.030175e-01 8.745875e-01 10 73208619 73208691 73 + 1.570 1.578 0.026
ENSG00000138286 E013 23.2297436 0.0008287847 9.275271e-01 9.584122e-01 10 73208692 73208696 5 + 1.380 1.380 0.000
ENSG00000138286 E014 42.8952760 0.0008289992 6.067794e-01 7.268576e-01 10 73208697 73208786 90 + 1.651 1.616 -0.118
ENSG00000138286 E015 29.5926003 0.0073893412 3.310944e-01 4.746919e-01 10 73210251 73210266 16 + 1.512 1.430 -0.283
ENSG00000138286 E016 65.0471048 0.0053845400 4.442069e-01 5.857672e-01 10 73210267 73210438 172 + 1.802 1.834 0.109
ENSG00000138286 E017 6.5470975 0.0026496447 5.979920e-01 7.196714e-01 10 73216515 73216571 57 + 0.894 0.822 -0.279
ENSG00000138286 E018 39.1218286 0.0008134039 2.777520e-01 4.173616e-01 10 73228060 73228106 47 + 1.579 1.634 0.187
ENSG00000138286 E019 36.1310873 0.0006372799 1.472818e-02 3.987780e-02 10 73228107 73228160 54 + 1.509 1.642 0.456
ENSG00000138286 E020 20.0518625 0.0009911573 3.619514e-02 8.395545e-02 10 73228161 73228184 24 + 1.258 1.410 0.529
ENSG00000138286 E021 2.2123082 0.0348676446 6.151878e-01 7.335210e-01 10 73230296 73230421 126 + 0.537 0.437 -0.493
ENSG00000138286 E022 41.3874495 0.0005772242 6.759577e-03 2.059977e-02 10 73230422 73230472 51 + 1.567 1.706 0.472
ENSG00000138286 E023 43.5469782 0.0005478672 2.301494e-02 5.777966e-02 10 73230473 73230525 53 + 1.600 1.713 0.383
ENSG00000138286 E024 43.3296782 0.0005276191 2.536916e-08 2.898328e-07 10 73230526 73231306 781 + 1.506 1.790 0.967
ENSG00000138286 E025 64.7942784 0.0043560150 4.222007e-02 9.512698e-02 10 73232939 73233163 225 + 1.774 1.874 0.339
ENSG00000138286 E026 1.3349424 0.0447698853 4.191118e-01 5.623675e-01 10 73233164 73233197 34 + 0.296 0.437 0.828
ENSG00000138286 E027 7.3824568 0.0022435304 5.903083e-01 7.131833e-01 10 73234108 73234816 709 + 0.945 0.875 -0.266
ENSG00000138286 E028 51.8669962 0.0120718569 2.854389e-01 4.257609e-01 10 73234817 73234940 124 + 1.690 1.768 0.266
ENSG00000138286 E029 0.6265839 0.0187283370 8.572307e-03 2.522010e-02 10 73234941 73235192 252 + 0.000 0.436 11.959
ENSG00000138286 E030 39.9096241 0.0021669038 3.093149e-02 7.377988e-02 10 73235193 73235318 126 + 1.559 1.678 0.408
ENSG00000138286 E031 18.1517807 0.0023975801 1.498224e-01 2.614392e-01 10 73235319 73238232 2914 + 1.227 1.338 0.389
ENSG00000138286 E032 10.3719882 0.0016852565 3.872784e-03 1.278602e-02 10 73239312 73239384 73 + 1.152 0.822 -1.227
ENSG00000138286 E033 64.7050221 0.0010352001 6.724862e-02 1.387820e-01 10 73240946 73244504 3559 + 1.844 1.752 -0.312