ENSG00000138246

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000260818 ENSG00000138246 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAJC13 protein_coding protein_coding 7.867658 4.344312 10.32485 0.1261203 0.3432552 1.247001 6.0105626 2.0216493 9.0342212 0.3976757 0.2604678 2.1543449 0.6789167 0.46946667 0.87726667 0.40780000 1.975042e-03 7.135704e-24 FALSE TRUE
ENST00000509279 ENSG00000138246 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAJC13 protein_coding nonsense_mediated_decay 7.867658 4.344312 10.32485 0.1261203 0.3432552 1.247001 0.6674534 1.9752010 0.0000000 0.3013908 0.0000000 -7.6331413 0.1489292 0.45213333 0.00000000 -0.45213333 7.135704e-24 7.135704e-24   FALSE
MSTRG.23696.2 ENSG00000138246 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAJC13 protein_coding   7.867658 4.344312 10.32485 0.1261203 0.3432552 1.247001 0.6440352 0.2389773 0.2175502 0.2389773 0.2175502 -0.1298295 0.1070750 0.05246667 0.01993333 -0.03253333 9.027309e-01 7.135704e-24 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000138246 E001 9.7394930 0.0053045451 1.651544e-01 2.818916e-01 3 132417502 132417699 198 + 1.012 0.855 -0.593
ENSG00000138246 E002 9.1086547 0.0047699979 7.031418e-02 1.438735e-01 3 132417700 132417707 8 + 0.997 0.773 -0.860
ENSG00000138246 E003 9.1086547 0.0047699979 7.031418e-02 1.438735e-01 3 132417708 132417708 1 + 0.997 0.773 -0.860
ENSG00000138246 E004 15.1377377 0.0069608810 3.676528e-02 8.502077e-02 3 132417709 132417760 52 + 1.198 0.983 -0.780
ENSG00000138246 E005 24.3301085 0.0058176607 1.032668e-06 8.540444e-06 3 132434538 132434618 81 + 1.428 0.924 -1.804
ENSG00000138246 E006 24.0457982 0.0036663121 2.188061e-05 1.344090e-04 3 132446475 132446550 76 + 1.414 1.010 -1.432
ENSG00000138246 E007 37.6345192 0.0122398181 7.195579e-05 3.897029e-04 3 132447321 132447470 150 + 1.593 1.246 -1.198
ENSG00000138246 E008 19.7836799 0.0023566401 1.745583e-04 8.551068e-04 3 132447898 132447939 42 + 1.328 0.955 -1.341
ENSG00000138246 E009 38.4094835 0.0007228980 2.240587e-05 1.373431e-04 3 132450647 132450847 201 + 1.593 1.303 -0.999
ENSG00000138246 E010 41.7936566 0.0005801523 5.445401e-06 3.844576e-05 3 132453298 132453504 207 + 1.629 1.329 -1.033
ENSG00000138246 E011 34.6408434 0.0005857303 2.924656e-05 1.744709e-04 3 132453599 132453694 96 + 1.549 1.246 -1.047
ENSG00000138246 E012 34.9911038 0.0006161219 9.736567e-06 6.492655e-05 3 132454066 132454157 92 + 1.555 1.231 -1.123
ENSG00000138246 E013 25.9946198 0.0014502174 9.142355e-02 1.773564e-01 3 132456235 132456293 59 + 1.393 1.276 -0.408
ENSG00000138246 E014 36.6812226 0.0047172871 1.762832e-03 6.481199e-03 3 132456294 132456401 108 + 1.559 1.330 -0.789
ENSG00000138246 E015 28.0983830 0.0012835604 8.679984e-04 3.501921e-03 3 132456501 132456580 80 + 1.458 1.198 -0.904
ENSG00000138246 E016 37.2899731 0.0006502485 5.919814e-03 1.839747e-02 3 132456663 132456832 170 + 1.559 1.388 -0.590
ENSG00000138246 E017 30.0554115 0.0007034600 1.420734e-01 2.508632e-01 3 132457269 132457368 100 + 1.452 1.365 -0.301
ENSG00000138246 E018 0.0000000       3 132457369 132458349 981 +      
ENSG00000138246 E019 29.5971956 0.0006945634 2.117148e-02 5.395963e-02 3 132460250 132460357 108 + 1.460 1.303 -0.544
ENSG00000138246 E020 33.2173549 0.0006364679 9.402091e-04 3.754791e-03 3 132461050 132461205 156 + 1.520 1.290 -0.799
ENSG00000138246 E021 27.4847590 0.0006798223 2.772886e-03 9.591989e-03 3 132462467 132462523 57 + 1.442 1.215 -0.791
ENSG00000138246 E022 32.8038863 0.0007227556 1.200081e-03 4.640589e-03 3 132463696 132463817 122 + 1.516 1.290 -0.783
ENSG00000138246 E023 0.7458221 0.0240233024 8.958627e-01 9.374538e-01 3 132465951 132465994 44 + 0.227 0.208 -0.161
ENSG00000138246 E024 30.6693406 0.0007052513 7.309410e-02 1.484807e-01 3 132465995 132466070 76 + 1.465 1.353 -0.387
ENSG00000138246 E025 26.6257384 0.0007487647 4.709555e-02 1.039946e-01 3 132466299 132466394 96 + 1.414 1.276 -0.481
ENSG00000138246 E026 33.8101368 0.0006136136 2.070695e-03 7.443226e-03 3 132467170 132467313 144 + 1.525 1.316 -0.721
ENSG00000138246 E027 0.0000000       3 132467314 132467346 33 +      
ENSG00000138246 E028 28.9183456 0.0072040306 2.381139e-06 1.821815e-05 3 132473145 132473227 83 + 1.492 1.037 -1.606
ENSG00000138246 E029 0.5858876 0.0207122655 9.228124e-01 9.553226e-01 3 132474256 132474383 128 + 0.181 0.208 0.255
ENSG00000138246 E030 44.1569656 0.0021839906 1.585135e-06 1.260172e-05 3 132474932 132475085 154 + 1.658 1.329 -1.131
ENSG00000138246 E031 40.7677028 0.0029961796 6.140003e-04 2.584671e-03 3 132477789 132477892 104 + 1.608 1.377 -0.793
ENSG00000138246 E032 40.5277721 0.0166583761 1.328146e-02 3.657384e-02 3 132477981 132478140 160 + 1.599 1.392 -0.711
ENSG00000138246 E033 22.9259596 0.0064221097 1.088980e-01 2.039132e-01 3 132479227 132479289 63 + 1.345 1.216 -0.452
ENSG00000138246 E034 29.1476843 0.0035725754 1.357898e-02 3.725880e-02 3 132480369 132480470 102 + 1.460 1.276 -0.639
ENSG00000138246 E035 37.3578895 0.0005478736 3.268198e-02 7.716712e-02 3 132482226 132482330 105 + 1.553 1.429 -0.425
ENSG00000138246 E036 49.0891389 0.0004660836 3.550370e-03 1.186988e-02 3 132483375 132483577 203 + 1.674 1.519 -0.530
ENSG00000138246 E037 1.1480412 0.0325499693 7.264095e-01 8.194328e-01 3 132484363 132484488 126 + 0.269 0.349 0.523
ENSG00000138246 E038 0.0000000       3 132484489 132484493 5 +      
ENSG00000138246 E039 27.3763568 0.0007991398 5.926071e-03 1.841472e-02 3 132484588 132484672 85 + 1.436 1.231 -0.716
ENSG00000138246 E040 46.7955035 0.0006764782 4.094064e-04 1.810646e-03 3 132488298 132488452 155 + 1.663 1.458 -0.701
ENSG00000138246 E041 31.0032448 0.0013496026 9.720534e-03 2.807589e-02 3 132488976 132489021 46 + 1.483 1.303 -0.622
ENSG00000138246 E042 46.8501951 0.0042321319 3.750285e-01 5.194490e-01 3 132490897 132491051 155 + 1.628 1.593 -0.118
ENSG00000138246 E043 52.3028096 0.0030666974 5.346375e-01 6.666588e-01 3 132492414 132492615 202 + 1.670 1.657 -0.044
ENSG00000138246 E044 36.3596351 0.0005661607 3.018332e-01 4.436574e-01 3 132494144 132494259 116 + 1.523 1.476 -0.159
ENSG00000138246 E045 26.9238198 0.0078445266 7.128647e-02 1.454607e-01 3 132495088 132495166 79 + 1.419 1.276 -0.498
ENSG00000138246 E046 37.0223366 0.0041446887 3.299556e-01 4.735359e-01 3 132496528 132496663 136 + 1.534 1.485 -0.166
ENSG00000138246 E047 56.2532048 0.0152440396 7.306895e-01 8.225410e-01 3 132499126 132499310 185 + 1.698 1.692 -0.020
ENSG00000138246 E048 39.5064605 0.0007474904 8.934650e-01 9.358972e-01 3 132499734 132499808 75 + 1.542 1.558 0.052
ENSG00000138246 E049 44.4565493 0.0022458743 9.260594e-01 9.574333e-01 3 132500794 132500913 120 + 1.595 1.613 0.062
ENSG00000138246 E050 53.1779902 0.0026441187 9.894615e-01 9.974379e-01 3 132502289 132502468 180 + 1.668 1.691 0.078
ENSG00000138246 E051 54.1338852 0.0007183123 7.015694e-01 8.006859e-01 3 132503214 132503381 168 + 1.682 1.685 0.010
ENSG00000138246 E052 44.9013751 0.0005132494 5.186087e-01 6.528468e-01 3 132505302 132505415 114 + 1.608 1.593 -0.050
ENSG00000138246 E053 48.8428153 0.0099871748 1.383635e-01 2.458226e-01 3 132507237 132507353 117 + 1.662 1.576 -0.291
ENSG00000138246 E054 60.3046331 0.0004334770 1.318055e-01 2.366324e-01 3 132511067 132511244 178 + 1.742 1.685 -0.191
ENSG00000138246 E055 45.3021782 0.0004988483 4.539699e-01 5.946760e-01 3 132513008 132513099 92 + 1.608 1.586 -0.073
ENSG00000138246 E056 50.3332231 0.0004921685 6.987191e-02 1.431633e-01 3 132514571 132514670 100 + 1.613 1.737 0.420
ENSG00000138246 E057 0.8815316 0.0136968632 1.614916e-01 2.770477e-01 3 132514671 132514816 146 + 0.308 0.000 -11.227
ENSG00000138246 E058 51.3340884 0.0004547792 4.153137e-02 9.387220e-02 3 132516422 132516496 75 + 1.617 1.752 0.457
ENSG00000138246 E059 60.0488900 0.0034330932 2.174664e-03 7.764404e-03 3 132516704 132516816 113 + 1.663 1.858 0.659
ENSG00000138246 E060 65.8123644 0.0018208415 2.323125e-04 1.101264e-03 3 132522828 132522972 145 + 1.700 1.909 0.704
ENSG00000138246 E061 43.8274243 0.0057763874 4.087559e-02 9.266223e-02 3 132522973 132522997 25 + 1.545 1.707 0.551
ENSG00000138246 E062 48.8973698 0.0082651071 1.047409e-03 4.123273e-03 3 132523157 132523199 43 + 1.562 1.809 0.839
ENSG00000138246 E063 78.4877818 0.0051302649 3.900527e-06 2.843510e-05 3 132523540 132523713 174 + 1.755 2.026 0.912
ENSG00000138246 E064 2.3721170 0.2606926080 5.440079e-01 6.745205e-01 3 132523714 132524017 304 + 0.510 0.357 -0.814
ENSG00000138246 E065 90.0442496 0.0018907761 2.358124e-07 2.229017e-06 3 132525610 132525789 180 + 1.822 2.072 0.841
ENSG00000138246 E066 76.4086078 0.0003948804 9.210942e-10 1.374545e-08 3 132526141 132526281 141 + 1.732 2.019 0.967
ENSG00000138246 E067 39.5478684 0.0038804922 5.739667e-05 3.185851e-04 3 132528189 132528201 13 + 1.452 1.738 0.975
ENSG00000138246 E068 67.9731735 0.0004083671 1.233455e-10 2.145178e-09 3 132528202 132528332 131 + 1.673 1.987 1.061
ENSG00000138246 E069 64.7417963 0.0032647702 2.397416e-09 3.313029e-08 3 132530998 132531097 100 + 1.646 1.982 1.132
ENSG00000138246 E070 0.1515154 0.0428451268 1.000000e+00   3 132537158 132537266 109 + 0.069 0.000 -8.643
ENSG00000138246 E071 181.9796252 0.0066085658 2.100187e-20 1.408903e-18 3 132538176 132539032 857 + 2.041 2.485 1.483