ENSG00000138193

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000371375 ENSG00000138193 HEK293_OSMI2_2hA HEK293_TMG_2hB PLCE1 protein_coding protein_coding 1.105681 0.9666963 1.318432 0.09275325 0.09235123 0.4437422 0.072482385 0.04224567 0.06048782 0.01687863 0.01091077 0.4320626 0.069820833 0.04550000 0.04606667 0.0005666667 0.975590395 0.009401692 FALSE TRUE
ENST00000675218 ENSG00000138193 HEK293_OSMI2_2hA HEK293_TMG_2hB PLCE1 protein_coding protein_coding 1.105681 0.9666963 1.318432 0.09275325 0.09235123 0.4437422 0.005848761 0.04679008 0.00000000 0.04679008 0.00000000 -2.5056391 0.007466667 0.05973333 0.00000000 -0.0597333333 0.670813378 0.009401692 FALSE TRUE
ENST00000685253 ENSG00000138193 HEK293_OSMI2_2hA HEK293_TMG_2hB PLCE1 protein_coding nonsense_mediated_decay 1.105681 0.9666963 1.318432 0.09275325 0.09235123 0.4437422 0.175453250 0.03901955 0.10661530 0.03901955 0.10661530 1.2503281 0.166608333 0.03776667 0.09266667 0.0549000000 1.000000000 0.009401692 FALSE TRUE
ENST00000685889 ENSG00000138193 HEK293_OSMI2_2hA HEK293_TMG_2hB PLCE1 protein_coding retained_intron 1.105681 0.9666963 1.318432 0.09275325 0.09235123 0.4437422 0.233143877 0.55184574 0.15701174 0.03306908 0.09362289 -1.7502245 0.234233333 0.57716667 0.11020000 -0.4669666667 0.009401692 0.009401692 FALSE TRUE
ENST00000687948 ENSG00000138193 HEK293_OSMI2_2hA HEK293_TMG_2hB PLCE1 protein_coding retained_intron 1.105681 0.9666963 1.318432 0.09275325 0.09235123 0.4437422 0.052372929 0.03730377 0.03336882 0.01796623 0.01670039 -0.1252968 0.055758333 0.03750000 0.02593333 -0.0115666667 0.818114852 0.009401692   FALSE
ENST00000692286 ENSG00000138193 HEK293_OSMI2_2hA HEK293_TMG_2hB PLCE1 protein_coding protein_coding 1.105681 0.9666963 1.318432 0.09275325 0.09235123 0.4437422 0.261865779 0.08244334 0.64203249 0.08244334 0.06489162 2.8183026 0.218516667 0.07606667 0.48580000 0.4097333333 0.038133898 0.009401692 FALSE TRUE
MSTRG.4406.4 ENSG00000138193 HEK293_OSMI2_2hA HEK293_TMG_2hB PLCE1 protein_coding   1.105681 0.9666963 1.318432 0.09275325 0.09235123 0.4437422 0.081485640 0.00000000 0.00000000 0.00000000 0.00000000 0.0000000 0.060454167 0.00000000 0.00000000 0.0000000000   0.009401692 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000138193 E001 0.4407149 0.021768165 0.7714369863 8.524540e-01 10 93993931 93994033 103 + 0.190 0.141 -0.517
ENSG00000138193 E002 1.2878016 0.010140464 0.8048696346 8.758444e-01 10 93994034 93994150 117 + 0.376 0.333 -0.252
ENSG00000138193 E003 2.4919544 0.010146267 0.7106614341 8.077896e-01 10 93994151 93994258 108 + 0.505 0.568 0.295
ENSG00000138193 E004 0.6664265 0.017764739 0.7451980962 8.333169e-01 10 93994534 93994550 17 + 0.190 0.248 0.485
ENSG00000138193 E005 1.9499748 0.007754049 0.9904909079 9.981995e-01 10 94030683 94030716 34 + 0.466 0.466 0.000
ENSG00000138193 E006 19.9978152 0.013416595 0.0000030674 2.289727e-05 10 94030717 94031975 1259 + 1.468 1.014 -1.603
ENSG00000138193 E007 7.3750329 0.010766285 0.0052102087 1.650323e-02 10 94031976 94032252 277 + 1.048 0.687 -1.399
ENSG00000138193 E008 0.0000000       10 94089040 94089094 55 +      
ENSG00000138193 E009 0.1472490 0.042753427 0.6551138250   10 94089095 94089145 51 + 0.106 0.000 -11.093
ENSG00000138193 E010 0.1472490 0.042753427 0.6551138250   10 94089146 94089376 231 + 0.106 0.000 -11.093
ENSG00000138193 E011 0.0000000       10 94108886 94109115 230 +      
ENSG00000138193 E012 0.0000000       10 94109116 94109170 55 +      
ENSG00000138193 E013 0.0000000       10 94120717 94121107 391 +      
ENSG00000138193 E014 6.2086965 0.002739671 0.0036199781 1.206746e-02 10 94132174 94132459 286 + 0.991 0.611 -1.515
ENSG00000138193 E015 4.5802857 0.003612727 0.0169184048 4.475391e-02 10 94171180 94171282 103 + 0.865 0.520 -1.453
ENSG00000138193 E016 8.3049492 0.002132305 0.0116489423 3.269757e-02 10 94171283 94171496 214 + 1.069 0.779 -1.099
ENSG00000138193 E017 5.7981404 0.004096745 0.3686785028 5.130798e-01 10 94227306 94227419 114 + 0.865 0.750 -0.451
ENSG00000138193 E018 2.8712472 0.005519453 0.2211458669 3.518022e-01 10 94227420 94227451 32 + 0.660 0.466 -0.893
ENSG00000138193 E019 8.4423568 0.002189303 0.1191743571 2.187631e-01 10 94234054 94234312 259 + 1.048 0.878 -0.637
ENSG00000138193 E020 5.7100387 0.002918017 0.4861435265 6.239554e-01 10 94235915 94236016 102 + 0.865 0.778 -0.338
ENSG00000138193 E021 5.4738172 0.005325381 0.6770975272 7.818969e-01 10 94236017 94236120 104 + 0.831 0.779 -0.206
ENSG00000138193 E022 17.7005241 0.009653237 0.2232818344 3.543106e-01 10 94245946 94246621 676 + 1.312 1.206 -0.372
ENSG00000138193 E023 6.5719123 0.002841095 0.9600246020 9.788896e-01 10 94252316 94252498 183 + 0.881 0.878 -0.013
ENSG00000138193 E024 0.2944980 0.295717022 0.3839597595   10 94253941 94254096 156 + 0.190 0.000 -12.092
ENSG00000138193 E025 5.0971103 0.013956229 0.3377924370 4.816813e-01 10 94254190 94254307 118 + 0.848 0.718 -0.520
ENSG00000138193 E026 4.6982020 0.003764603 0.0253999314 6.270202e-02 10 94254893 94254935 43 + 0.881 0.567 -1.294
ENSG00000138193 E027 5.6204179 0.015445116 0.0153281011 4.123224e-02 10 94254936 94255001 66 + 0.953 0.610 -1.378
ENSG00000138193 E028 4.0211769 0.014385642 0.2654123580 4.034727e-01 10 94255002 94255049 48 + 0.775 0.610 -0.688
ENSG00000138193 E029 0.9329388 0.268787142 0.3195671590 4.626504e-01 10 94255050 94255887 838 + 0.377 0.142 -1.839
ENSG00000138193 E030 0.2955422 0.029407894 0.8109983107   10 94258511 94258799 289 + 0.106 0.141 0.482
ENSG00000138193 E031 6.2708586 0.034576675 0.8204380693 8.867348e-01 10 94258800 94258922 123 + 0.881 0.852 -0.111
ENSG00000138193 E032 7.1556324 0.002724345 0.1687523449 2.865560e-01 10 94259014 94259150 137 + 0.831 0.994 0.616
ENSG00000138193 E033 9.0744496 0.001844049 0.8783492451 9.258779e-01 10 94262494 94262732 239 + 0.991 1.010 0.070
ENSG00000138193 E034 0.0000000       10 94264519 94265646 1128 +      
ENSG00000138193 E035 5.9691379 0.003059579 0.1032490416 1.954205e-01 10 94265647 94265708 62 + 0.926 0.719 -0.810
ENSG00000138193 E036 8.4668874 0.002107457 0.0048177301 1.542356e-02 10 94265793 94265958 166 + 1.099 0.778 -1.208
ENSG00000138193 E037 0.0000000       10 94265959 94266435 477 +      
ENSG00000138193 E038 6.7674244 0.002479034 0.2136813774 3.428701e-01 10 94268929 94269036 108 + 0.953 0.805 -0.566
ENSG00000138193 E039 7.0762023 0.002613021 0.6683383939 7.753740e-01 10 94270486 94270602 117 + 0.926 0.878 -0.182
ENSG00000138193 E040 9.5528421 0.001795508 0.9346681510 9.628554e-01 10 94273562 94273720 159 + 1.015 1.026 0.041
ENSG00000138193 E041 9.1522409 0.009217910 0.0758323200 1.528320e-01 10 94279782 94279911 130 + 0.896 1.099 0.751
ENSG00000138193 E042 0.0000000       10 94279912 94281321 1410 +      
ENSG00000138193 E043 0.0000000       10 94281322 94282790 1469 +      
ENSG00000138193 E044 0.0000000       10 94282791 94282793 3 +      
ENSG00000138193 E045 0.2214452 0.038189878 0.3562998966   10 94282794 94282832 39 + 0.000 0.142 11.792
ENSG00000138193 E046 0.0000000       10 94282833 94282940 108 +      
ENSG00000138193 E047 0.1515154 0.042567608 0.6546467631   10 94282941 94283789 849 + 0.106 0.000 -11.093
ENSG00000138193 E048 7.7802021 0.002208505 0.2058163796 3.334299e-01 10 94283790 94283911 122 + 0.865 1.010 0.547
ENSG00000138193 E049 9.0182349 0.002004815 0.5900908888 7.130252e-01 10 94284848 94284965 118 + 0.966 1.026 0.222
ENSG00000138193 E050 0.1472490 0.042753427 0.6551138250   10 94293054 94293507 454 + 0.106 0.000 -11.093
ENSG00000138193 E051 8.0423451 0.002195241 0.0639660023 1.332985e-01 10 94293508 94293639 132 + 0.848 1.057 0.780
ENSG00000138193 E052 12.0058844 0.001553515 0.3448945042 4.889896e-01 10 94298379 94298669 291 + 1.069 1.161 0.329
ENSG00000138193 E053 8.2940334 0.004743161 0.7146093570 8.107438e-01 10 94304482 94304645 164 + 0.979 0.940 -0.146
ENSG00000138193 E054 11.7713211 0.063498172 0.4959928155 6.327289e-01 10 94306427 94306688 262 + 1.038 1.151 0.410
ENSG00000138193 E055 9.3859540 0.052811931 0.1472921071 2.580101e-01 10 94308581 94308699 119 + 0.881 1.110 0.844
ENSG00000138193 E056 0.0000000       10 94309642 94313253 3612 +      
ENSG00000138193 E057 8.7724433 0.002160666 0.0028366946 9.783777e-03 10 94313254 94313382 129 + 0.794 1.125 1.238
ENSG00000138193 E058 13.5851670 0.001447952 0.0004844072 2.100421e-03 10 94316547 94316756 210 + 0.979 1.298 1.146
ENSG00000138193 E059 14.0524173 0.011300219 0.1228986438 2.240905e-01 10 94321901 94322059 159 + 1.099 1.253 0.551
ENSG00000138193 E060 8.3047061 0.041068114 0.4956971653 6.324703e-01 10 94324349 94324377 29 + 0.926 1.022 0.360
ENSG00000138193 E061 17.4633003 0.001388214 0.0077066099 2.304247e-02 10 94324378 94324567 190 + 1.152 1.368 0.758
ENSG00000138193 E062 16.7925525 0.002353871 0.0009666863 3.844242e-03 10 94324892 94325104 213 + 1.099 1.375 0.975
ENSG00000138193 E063 0.2903454 0.338837621 0.3947130429   10 94325105 94325202 98 + 0.190 0.000 -12.088
ENSG00000138193 E064 6.9341254 0.025458843 0.6928104418 7.939440e-01 10 94325203 94327967 2765 + 0.925 0.876 -0.188
ENSG00000138193 E065 23.6081175 0.032840042 0.0191177333 4.959532e-02 10 94327968 94332823 4856 + 1.250 1.508 0.897