ENSG00000138190

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000260762 ENSG00000138190 HEK293_OSMI2_2hA HEK293_TMG_2hB EXOC6 protein_coding protein_coding 8.391147 3.166416 13.92719 0.2624872 0.09213261 2.133467 5.9818433 1.2668486 10.366811 0.2424974 0.64790253 3.022704 0.6672333 0.4178667 0.7439667 0.32610000 0.0533760878 0.0002032564 FALSE TRUE
ENST00000495132 ENSG00000138190 HEK293_OSMI2_2hA HEK293_TMG_2hB EXOC6 protein_coding nonsense_mediated_decay 8.391147 3.166416 13.92719 0.2624872 0.09213261 2.133467 0.3906007 1.0634059 0.154999 0.3809106 0.09375208 -2.701667 0.1044875 0.3214333 0.0112000 -0.31023333 0.0002032564 0.0002032564 TRUE TRUE
MSTRG.4391.5 ENSG00000138190 HEK293_OSMI2_2hA HEK293_TMG_2hB EXOC6 protein_coding   8.391147 3.166416 13.92719 0.2624872 0.09213261 2.133467 1.8340985 0.7187359 3.019114 0.1263639 0.39813829 2.055428 0.2038208 0.2286667 0.2171333 -0.01153333 0.9840567863 0.0002032564 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000138190 E001 0.0000000       10 92826831 92826944 114 +      
ENSG00000138190 E002 0.0000000       10 92831178 92831357 180 +      
ENSG00000138190 E003 0.0000000       10 92834713 92834824 112 +      
ENSG00000138190 E004 0.0000000       10 92848468 92848477 10 +      
ENSG00000138190 E005 1.0457324 0.0216637860 2.639030e-01 4.018274e-01 10 92848478 92848484 7 + 0.273 0.000 -10.129
ENSG00000138190 E006 6.1158284 0.0261029154 4.174912e-02 9.427327e-02 10 92848485 92848519 35 + 0.769 0.431 -1.522
ENSG00000138190 E007 43.9011924 0.0005467294 1.323830e-03 5.056158e-03 10 92848520 92848634 115 + 1.531 1.379 -0.523
ENSG00000138190 E008 68.6065231 0.0003723352 5.386903e-05 3.010598e-04 10 92893349 92893520 172 + 1.718 1.564 -0.524
ENSG00000138190 E009 39.4522786 0.0017347431 1.402417e-04 7.046189e-04 10 92894794 92894841 48 + 1.492 1.255 -0.824
ENSG00000138190 E010 49.7496548 0.0004625795 1.190066e-04 6.093528e-04 10 92894930 92895020 91 + 1.585 1.394 -0.655
ENSG00000138190 E011 37.5526031 0.0013809820 2.425870e-02 6.034556e-02 10 92899599 92899644 46 + 1.452 1.364 -0.306
ENSG00000138190 E012 0.1451727 0.0427107022 1.000000e+00   10 92899645 92901851 2207 + 0.051 0.000 -7.315
ENSG00000138190 E013 43.0491593 0.0005546007 4.529081e-03 1.462502e-02 10 92909427 92909483 57 + 1.516 1.394 -0.420
ENSG00000138190 E014 57.3936389 0.0004022399 6.467867e-03 1.983935e-02 10 92909484 92909631 148 + 1.634 1.554 -0.272
ENSG00000138190 E015 63.4196029 0.0003630878 3.277775e-03 1.108537e-02 10 92915758 92915913 156 + 1.678 1.593 -0.289
ENSG00000138190 E016 0.7362571 0.0834242808 2.175944e-01 3.474947e-01 10 92915914 92916030 117 + 0.138 0.428 2.169
ENSG00000138190 E017 45.9682193 0.0004841346 8.893299e-04 3.576557e-03 10 92919982 92920050 69 + 1.549 1.394 -0.535
ENSG00000138190 E018 48.9380941 0.0005112626 3.441391e-04 1.556662e-03 10 92928339 92928373 35 + 1.578 1.409 -0.580
ENSG00000138190 E019 48.5792096 0.0063007901 9.202774e-04 3.685759e-03 10 92928374 92928422 49 + 1.577 1.394 -0.629
ENSG00000138190 E020 46.6077746 0.0004813593 4.054547e-03 1.329390e-02 10 92934144 92934190 47 + 1.551 1.436 -0.393
ENSG00000138190 E021 57.5181956 0.0003994365 3.749405e-02 8.639392e-02 10 92934310 92934430 121 + 1.628 1.593 -0.116
ENSG00000138190 E022 49.4383360 0.0004836295 1.682389e-02 4.454236e-02 10 92935814 92935885 72 + 1.569 1.499 -0.238
ENSG00000138190 E023 58.2541210 0.0080319147 1.002281e-01 1.908256e-01 10 92940727 92940824 98 + 1.632 1.605 -0.092
ENSG00000138190 E024 57.4153610 0.0037335393 3.035033e-01 4.454189e-01 10 92948274 92948379 106 + 1.618 1.647 0.098
ENSG00000138190 E025 26.1047626 0.0007144824 4.156825e-01 5.590485e-01 10 92952273 92952275 3 + 1.289 1.312 0.081
ENSG00000138190 E026 55.6301483 0.0004444842 7.421011e-01 8.311046e-01 10 92952276 92952382 107 + 1.589 1.708 0.406
ENSG00000138190 E027 61.3724141 0.0004186417 2.391168e-01 3.730726e-01 10 92954630 92954741 112 + 1.621 1.787 0.563
ENSG00000138190 E028 71.0653500 0.0003351828 7.541072e-01 8.398260e-01 10 92955580 92955714 135 + 1.694 1.811 0.395
ENSG00000138190 E029 68.3682663 0.0038290184 4.515688e-01 5.925140e-01 10 92974053 92974232 180 + 1.671 1.817 0.494
ENSG00000138190 E030 50.1047427 0.0149852047 5.246291e-01 6.581077e-01 10 92997474 92997615 142 + 1.539 1.695 0.530
ENSG00000138190 E031 2.5850545 0.0820446673 1.589822e-01 2.737690e-01 10 92999250 92999387 138 + 0.375 0.723 1.640
ENSG00000138190 E032 44.0793722 0.0012733486 1.534663e-01 2.663743e-01 10 93014194 93014267 74 + 1.476 1.671 0.663
ENSG00000138190 E033 61.6992002 0.0045499298 5.123621e-01 6.472714e-01 10 93056924 93057036 113 + 1.628 1.770 0.481
ENSG00000138190 E034 255.0301710 0.0369391394 2.345024e-06 1.796723e-05 10 93058223 93059493 1271 + 2.147 2.631 1.614