ENSG00000138182

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000260753 ENSG00000138182 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF20B protein_coding protein_coding 9.80993 1.886266 16.67026 0.2104657 0.8772955 3.136909 5.9876362 0.1688792 9.2585723 0.1688792 1.1830711 5.695290 0.44363750 0.07956667 0.55736667 0.4778000 3.380126e-02 1.205682e-07 FALSE TRUE
ENST00000371728 ENSG00000138182 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF20B protein_coding protein_coding 9.80993 1.886266 16.67026 0.2104657 0.8772955 3.136909 0.6534385 0.3065978 0.8759015 0.1699158 0.1669464 1.484495 0.08375417 0.17020000 0.05180000 -0.1184000 6.393463e-01 1.205682e-07 FALSE TRUE
ENST00000478929 ENSG00000138182 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF20B protein_coding processed_transcript 9.80993 1.886266 16.67026 0.2104657 0.8772955 3.136909 0.8815229 1.3396883 0.4442919 0.1436257 0.2436194 -1.570935 0.33302500 0.71586667 0.02553333 -0.6903333 1.143879e-04 1.205682e-07 FALSE TRUE
MSTRG.4355.2 ENSG00000138182 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF20B protein_coding   9.80993 1.886266 16.67026 0.2104657 0.8772955 3.136909 2.1519468 0.0000000 5.9017716 0.0000000 1.2785120 9.207447 0.12886667 0.00000000 0.35470000 0.3547000 1.205682e-07 1.205682e-07 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000138182 E001 1.1330771 0.0821205732 2.676724e-03 9.302931e-03 10 89701590 89701609 20 + 0.108 0.740 3.995
ENSG00000138182 E002 24.2585638 0.0185282600 7.941303e-02 1.586025e-01 10 89701610 89701678 69 + 1.192 1.000 -0.694
ENSG00000138182 E003 23.8178489 0.0231723143 4.921612e-02 1.077665e-01 10 89701679 89701680 2 + 1.187 0.949 -0.867
ENSG00000138182 E004 0.7718584 0.0157593424 6.048961e-02 1.274532e-01 10 89701681 89701717 37 + 0.108 0.512 2.995
ENSG00000138182 E005 52.4142605 0.0010159193 7.435776e-04 3.055982e-03 10 89705294 89705441 148 + 1.515 1.252 -0.909
ENSG00000138182 E006 51.7566343 0.0012587177 1.719376e-04 8.435341e-04 10 89709167 89709253 87 + 1.511 1.194 -1.103
ENSG00000138182 E007 52.0878218 0.0115082290 1.226113e-04 6.258142e-04 10 89709345 89709461 117 + 1.517 1.126 -1.365
ENSG00000138182 E008 54.7471531 0.0118742646 6.684359e-06 4.625362e-05 10 89709927 89710065 139 + 1.541 1.047 -1.735
ENSG00000138182 E009 51.8501682 0.0004655405 1.291031e-06 1.047012e-05 10 89710961 89711145 185 + 1.517 1.047 -1.654
ENSG00000138182 E010 18.3170824 0.0010091838 3.181587e-03 1.080164e-02 10 89714047 89714083 37 + 1.090 0.641 -1.741
ENSG00000138182 E011 39.9125330 0.0008068210 8.545786e-04 3.453884e-03 10 89714955 89715182 228 + 1.403 1.088 -1.108
ENSG00000138182 E012 38.4760233 0.0006354355 1.227084e-05 7.986374e-05 10 89716436 89716547 112 + 1.393 0.890 -1.811
ENSG00000138182 E013 35.1487611 0.0038164107 1.627710e-02 4.333748e-02 10 89717424 89717495 72 + 1.342 1.127 -0.760
ENSG00000138182 E014 63.1293446 0.0003955654 3.225046e-05 1.903468e-04 10 89717576 89717722 147 + 1.593 1.279 -1.084
ENSG00000138182 E015 65.1445104 0.0006071622 1.940726e-06 1.513895e-05 10 89718710 89718872 163 + 1.609 1.224 -1.329
ENSG00000138182 E016 90.5609825 0.0026409553 4.854279e-08 5.249322e-07 10 89719419 89719706 288 + 1.751 1.350 -1.371
ENSG00000138182 E017 1.7715959 0.0084681047 2.888200e-01 4.294591e-01 10 89723576 89723963 388 + 0.328 0.000 -10.015
ENSG00000138182 E018 63.9238081 0.0010257954 1.733721e-04 8.499114e-04 10 89723964 89724103 140 + 1.597 1.328 -0.929
ENSG00000138182 E019 62.1340518 0.0003848831 5.275211e-06 3.734438e-05 10 89725020 89725158 139 + 1.591 1.224 -1.270
ENSG00000138182 E020 2.9604247 0.0096622448 1.077070e-01 2.021576e-01 10 89726293 89726412 120 + 0.460 0.001 -10.642
ENSG00000138182 E021 49.4288085 0.0050191214 3.653281e-06 2.683399e-05 10 89726413 89726521 109 + 1.499 1.000 -1.762
ENSG00000138182 E022 27.2042187 0.0073130107 1.222364e-03 4.716264e-03 10 89727856 89727896 41 + 1.249 0.822 -1.572
ENSG00000138182 E023 40.6334881 0.0116207875 3.864831e-04 1.722494e-03 10 89729128 89729247 120 + 1.412 1.002 -1.457
ENSG00000138182 E024 56.4715982 0.0019327953 3.676712e-05 2.137878e-04 10 89732903 89733056 154 + 1.547 1.194 -1.225
ENSG00000138182 E025 302.9613093 0.0002143219 9.505243e-06 6.350472e-05 10 89737387 89738617 1231 + 2.251 2.162 -0.299
ENSG00000138182 E026 67.3158810 0.0095106532 2.251483e-02 5.675229e-02 10 89738958 89739096 139 + 1.612 1.465 -0.502
ENSG00000138182 E027 73.1841924 0.0014644614 7.310701e-01 8.228171e-01 10 89743808 89743927 120 + 1.629 1.674 0.153
ENSG00000138182 E028 64.5631405 0.0003871282 3.055818e-01 4.477029e-01 10 89745899 89745959 61 + 1.565 1.704 0.471
ENSG00000138182 E029 80.1822079 0.0003468999 6.754975e-01 7.807726e-01 10 89751346 89751471 126 + 1.663 1.758 0.321
ENSG00000138182 E030 81.5639865 0.0003862660 3.595635e-01 5.038889e-01 10 89752567 89752691 125 + 1.666 1.791 0.424
ENSG00000138182 E031 89.7821808 0.0130565216 3.364583e-01 4.803067e-01 10 89754518 89754673 156 + 1.703 1.858 0.524
ENSG00000138182 E032 89.1522167 0.0011141417 4.198473e-01 5.630987e-01 10 89758706 89758882 177 + 1.705 1.822 0.396
ENSG00000138182 E033 67.5530715 0.0003610348 9.772943e-02 1.870326e-01 10 89760526 89760636 111 + 1.582 1.758 0.599
ENSG00000138182 E034 97.5224463 0.0006567264 2.812006e-03 9.709761e-03 10 89762638 89762835 198 + 1.731 1.959 0.771
ENSG00000138182 E035 80.4832280 0.0064477003 5.237874e-06 3.709808e-05 10 89768290 89768391 102 + 1.624 1.988 1.229
ENSG00000138182 E036 102.5659153 0.0017386363 3.626377e-08 4.017581e-07 10 89768738 89768888 151 + 1.730 2.081 1.182
ENSG00000138182 E037 91.9009425 0.0003433019 7.579042e-10 1.149305e-08 10 89772689 89772831 143 + 1.676 2.055 1.277
ENSG00000138182 E038 165.5563457 0.0225405075 1.160661e-12 2.817215e-11 10 89773971 89774722 752 + 1.881 2.477 1.993
ENSG00000138182 E039 32.6168007 0.0948246618 8.918042e-06 5.998993e-05 10 89774723 89774939 217 + 1.121 1.938 2.811
ENSG00000138182 E040 0.1472490 0.0446579134 5.716567e-01   10 89792839 89792896 58 + 0.039 0.001 -6.156