ENSG00000138162

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000360561 ENSG00000138162 HEK293_OSMI2_2hA HEK293_TMG_2hB TACC2 protein_coding protein_coding 1.983539 2.913718 1.288104 0.5214565 0.07828006 -1.171398 0.06677620 0.02553882 0.11501328 0.02553882 0.02448551 1.8146138 0.03739167 0.00880000 0.08803333 0.07923333 0.01167173 0.01167173 FALSE TRUE
ENST00000503769 ENSG00000138162 HEK293_OSMI2_2hA HEK293_TMG_2hB TACC2 protein_coding retained_intron 1.983539 2.913718 1.288104 0.5214565 0.07828006 -1.171398 0.12568521 0.18415663 0.07870588 0.12207982 0.03943170 -1.1301194 0.05780833 0.05966667 0.05816667 -0.00150000 0.95111737 0.01167173 FALSE FALSE
ENST00000635597 ENSG00000138162 HEK293_OSMI2_2hA HEK293_TMG_2hB TACC2 protein_coding protein_coding 1.983539 2.913718 1.288104 0.5214565 0.07828006 -1.171398 0.08071939 0.31763546 0.00000000 0.31763546 0.00000000 -5.0340196 0.02403333 0.08306667 0.00000000 -0.08306667 0.88645662 0.01167173 FALSE TRUE
MSTRG.4752.13 ENSG00000138162 HEK293_OSMI2_2hA HEK293_TMG_2hB TACC2 protein_coding   1.983539 2.913718 1.288104 0.5214565 0.07828006 -1.171398 0.34176968 0.34924261 0.44116446 0.13457649 0.25553296 0.3286949 0.18769167 0.11143333 0.36843333 0.25700000 0.61624064 0.01167173 FALSE TRUE
MSTRG.4752.16 ENSG00000138162 HEK293_OSMI2_2hA HEK293_TMG_2hB TACC2 protein_coding   1.983539 2.913718 1.288104 0.5214565 0.07828006 -1.171398 0.26853121 0.64710020 0.12829501 0.59908965 0.07065997 -2.2483643 0.13687083 0.22800000 0.09366667 -0.13433333 1.00000000 0.01167173 FALSE TRUE
MSTRG.4752.23 ENSG00000138162 HEK293_OSMI2_2hA HEK293_TMG_2hB TACC2 protein_coding   1.983539 2.913718 1.288104 0.5214565 0.07828006 -1.171398 0.72054063 1.02170608 0.35833883 0.51088946 0.19042331 -1.4859266 0.35653750 0.38600000 0.26243333 -0.12356667 0.94232073 0.01167173 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000138162 E001 0.0000000       10 121989163 121989173 11 +      
ENSG00000138162 E002 0.0000000       10 121989174 121989193 20 +      
ENSG00000138162 E003 0.0000000       10 121989194 121989205 12 +      
ENSG00000138162 E004 0.0000000       10 121989206 121989262 57 +      
ENSG00000138162 E005 0.0000000       10 121989263 121989488 226 +      
ENSG00000138162 E006 0.0000000       10 121994632 121994710 79 +      
ENSG00000138162 E007 0.5244761 0.1761672153 0.229793266 0.362203866 10 122019748 122019881 134 + 0.307 0.082 -2.299
ENSG00000138162 E008 0.0000000       10 122021936 122021936 1 +      
ENSG00000138162 E009 0.6759915 0.3977294098 0.190359969 0.314214603 10 122021937 122021992 56 + 0.406 0.083 -2.870
ENSG00000138162 E010 0.3030308 0.2434134818 0.079414545   10 122021993 122022014 22 + 0.307 0.000 -14.153
ENSG00000138162 E011 0.0000000       10 122022015 122023790 1776 +      
ENSG00000138162 E012 0.0000000       10 122033094 122033153 60 +      
ENSG00000138162 E013 0.7426990 0.0201354462 0.866587508 0.918123423 10 122050438 122050550 113 + 0.180 0.210 0.274
ENSG00000138162 E014 0.1817044 0.0394807288 1.000000000   10 122050551 122052697 2147 + 0.000 0.082 10.585
ENSG00000138162 E015 0.0000000       10 122078977 122079145 169 +      
ENSG00000138162 E016 0.2214452 0.0374395701 1.000000000   10 122082647 122082655 9 + 0.000 0.082 10.588
ENSG00000138162 E017 23.5711456 0.0009211393 0.648803937 0.760257696 10 122082656 122087959 5304 + 1.353 1.310 -0.149
ENSG00000138162 E018 2.7271266 0.0060130974 0.422761190 0.565897018 10 122088478 122088591 114 + 0.405 0.542 0.689
ENSG00000138162 E019 0.2214452 0.0374395701 1.000000000   10 122088592 122088738 147 + 0.000 0.082 10.588
ENSG00000138162 E020 1.2274342 0.0134524961 0.448414911 0.589707194 10 122113011 122113029 19 + 0.405 0.262 -0.896
ENSG00000138162 E021 0.8942144 0.0865098711 0.634349342 0.748827490 10 122113030 122113038 9 + 0.307 0.210 -0.720
ENSG00000138162 E022 1.2576232 0.0119616260 0.972619897 0.986914627 10 122113039 122113055 17 + 0.307 0.308 0.011
ENSG00000138162 E023 3.6525768 0.0044268348 0.678752705 0.783144717 10 122113056 122113229 174 + 0.662 0.590 -0.312
ENSG00000138162 E024 1.1813376 0.0152552327 0.446182892 0.587693877 10 122113230 122113233 4 + 0.405 0.262 -0.897
ENSG00000138162 E025 0.1482932 0.0416354159 1.000000000   10 122126714 122127142 429 + 0.000 0.081 10.580
ENSG00000138162 E026 2.4649720 0.0940756524 0.354980918 0.499321146 10 122132609 122132734 126 + 0.610 0.429 -0.867
ENSG00000138162 E027 0.4720498 0.2006754513 0.230885713 0.363535618 10 122143572 122143706 135 + 0.306 0.082 -2.306
ENSG00000138162 E028 0.4783925 0.0221116583 0.183556802 0.305668402 10 122163426 122163589 164 + 0.307 0.082 -2.313
ENSG00000138162 E029 0.7771569 0.0152211388 0.019819285 0.051101791 10 122163590 122163773 184 + 0.485 0.082 -3.313
ENSG00000138162 E030 0.4804688 0.0221532242 0.183413152 0.305487559 10 122163774 122163843 70 + 0.307 0.082 -2.313
ENSG00000138162 E031 0.7739347 0.0149260984 0.156222865 0.270085353 10 122163844 122163931 88 + 0.405 0.150 -1.899
ENSG00000138162 E032 0.7331366 0.0193281308 0.019951864 0.051385583 10 122163932 122163992 61 + 0.484 0.081 -3.314
ENSG00000138162 E033 0.5085815 0.2192196645 0.859528065 0.913376935 10 122192448 122192797 350 + 0.180 0.151 -0.304
ENSG00000138162 E034 8.4087851 0.0828202176 0.130917074 0.235427244 10 122195040 122195176 137 + 1.106 0.824 -1.051
ENSG00000138162 E035 0.0000000       10 122209874 122209969 96 +      
ENSG00000138162 E036 0.0000000       10 122210042 122210396 355 +      
ENSG00000138162 E037 25.3257431 0.0101775526 0.001931265 0.007012676 10 122210397 122210885 489 + 1.529 1.272 -0.889
ENSG00000138162 E038 7.5721898 0.0090156506 0.640272017 0.753546414 10 122210886 122210902 17 + 0.913 0.846 -0.255
ENSG00000138162 E039 16.1751609 0.0211876201 0.276660242 0.416127070 10 122210903 122211157 255 + 1.253 1.133 -0.426
ENSG00000138162 E040 8.9382647 0.0117189583 0.745272612 0.833361203 10 122211158 122211208 51 + 0.964 0.918 -0.175
ENSG00000138162 E041 14.7589255 0.0274008255 0.436435440 0.578509670 10 122211209 122211422 214 + 1.201 1.105 -0.342
ENSG00000138162 E042 9.6045935 0.0019063410 0.125914032 0.228449732 10 122211423 122211496 74 + 1.089 0.915 -0.643
ENSG00000138162 E043 16.1844996 0.0014700521 0.643464431 0.756007356 10 122211497 122211685 189 + 1.215 1.165 -0.176
ENSG00000138162 E044 7.7842598 0.0023214730 0.485606118 0.623473432 10 122211686 122211708 23 + 0.822 0.904 0.315
ENSG00000138162 E045 0.0000000       10 122213342 122213377 36 +      
ENSG00000138162 E046 6.5988568 0.0026381637 0.303449184 0.445360181 10 122215391 122215402 12 + 0.708 0.845 0.546
ENSG00000138162 E047 9.2946762 0.0021249205 0.454922792 0.595504258 10 122215403 122215451 49 + 0.885 0.967 0.309
ENSG00000138162 E048 19.8625710 0.0015673390 0.476169673 0.614833024 10 122216627 122216828 202 + 1.301 1.234 -0.235
ENSG00000138162 E049 0.2214452 0.0374395701 1.000000000   10 122216829 122216921 93 + 0.000 0.082 10.588
ENSG00000138162 E050 9.3604428 0.0019337108 0.934868362 0.963004081 10 122224726 122224787 62 + 0.964 0.947 -0.064
ENSG00000138162 E051 16.1354042 0.0012391820 0.312522655 0.455059908 10 122226366 122226481 116 + 1.107 1.195 0.313
ENSG00000138162 E052 17.1522786 0.0052474997 0.354415734 0.498711294 10 122227837 122228008 172 + 1.141 1.222 0.289
ENSG00000138162 E053 0.6976476 0.0713372061 0.403021473 0.546814838 10 122229346 122229486 141 + 0.307 0.151 -1.304
ENSG00000138162 E054 0.3299976 0.0278874153 0.570974550   10 122230351 122230440 90 + 0.000 0.150 11.513
ENSG00000138162 E055 19.0423908 0.0198224123 0.755556421 0.840852800 10 122237395 122237538 144 + 1.266 1.227 -0.139
ENSG00000138162 E056 0.0000000       10 122237959 122237960 2 +      
ENSG00000138162 E057 14.6412375 0.0013629166 0.856112782 0.911050809 10 122237961 122238018 58 + 1.124 1.133 0.033
ENSG00000138162 E058 13.5566220 0.0093557047 0.216892095 0.346650779 10 122238019 122238037 19 + 1.010 1.139 0.467
ENSG00000138162 E059 1.2804253 0.0550347532 0.976806284 0.989519552 10 122241634 122241957 324 + 0.307 0.310 0.023
ENSG00000138162 E060 15.9514738 0.0067079347 0.163320249 0.279501452 10 122241958 122242001 44 + 1.071 1.205 0.481
ENSG00000138162 E061 0.0000000       10 122245065 122245073 9 +      
ENSG00000138162 E062 1.7284253 0.0081333665 0.145552048 0.255616727 10 122246473 122248642 2170 + 0.180 0.456 1.856
ENSG00000138162 E063 24.9043461 0.0008801785 0.174564942 0.294132651 10 122248643 122248803 161 + 1.278 1.375 0.339
ENSG00000138162 E064 17.6067830 0.0012870911 0.184427361 0.306778118 10 122249050 122249094 45 + 1.124 1.238 0.406
ENSG00000138162 E065 18.8006912 0.0077217341 0.171216386 0.289771397 10 122249095 122249156 62 + 1.141 1.268 0.450
ENSG00000138162 E066 16.9370732 0.0081477610 0.091755198 0.177872285 10 122249544 122249664 121 + 1.071 1.237 0.593
ENSG00000138162 E067 19.4214885 0.0266918737 0.560787051 0.688717039 10 122253991 122254126 136 + 1.201 1.267 0.231
ENSG00000138162 E068 25.1021027 0.0028389124 0.030512269 0.072970136 10 122254127 122254545 419 + 1.215 1.387 0.603