ENSG00000138160

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000260731 ENSG00000138160 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF11 protein_coding protein_coding 30.34838 9.09672 49.04558 0.5782091 1.720579 2.429414 27.100517 4.158694 47.42038 1.2255104 1.462734 3.508144 0.7697125 0.4445667 0.9672333 0.5226667 1.513930e-07 6.925578e-20 FALSE TRUE
ENST00000676757 ENSG00000138160 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF11 protein_coding protein_coding 30.34838 9.09672 49.04558 0.5782091 1.720579 2.429414 2.132214 4.641743 0.00000 0.6373062 0.000000 -8.861627 0.1992167 0.5219667 0.0000000 -0.5219667 6.925578e-20 6.925578e-20 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000138160 E001 0.0000000       10 92574105 92574193 89 +      
ENSG00000138160 E002 0.7342825 0.0160763898 4.570854e-01 5.974528e-01 10 92591733 92591829 97 + 0.214 0.001 -8.923
ENSG00000138160 E003 13.4098495 0.0012268210 3.604553e-02 8.367139e-02 10 92593130 92593136 7 + 1.058 0.834 -0.840
ENSG00000138160 E004 189.8835419 0.0063109533 1.779699e-10 3.007928e-09 10 92593137 92593452 316 + 2.176 1.880 -0.992
ENSG00000138160 E005 1.6243469 0.0385781566 1.236132e-01 2.251032e-01 10 92605507 92605581 75 + 0.380 0.001 -10.051
ENSG00000138160 E006 194.1318764 0.0006925492 3.886945e-15 1.360122e-13 10 92606265 92606397 133 + 2.182 1.922 -0.872
ENSG00000138160 E007 159.0179275 0.0024946217 3.819282e-12 8.515376e-11 10 92606619 92606716 98 + 2.099 1.809 -0.974
ENSG00000138160 E008 155.4096028 0.0002584281 9.424526e-09 1.168258e-07 10 92607159 92607237 79 + 2.077 1.899 -0.596
ENSG00000138160 E009 207.0505924 0.0009813178 3.177970e-08 3.560150e-07 10 92609020 92609205 186 + 2.199 2.052 -0.492
ENSG00000138160 E010 210.8290726 0.0001952502 3.766325e-10 6.033987e-09 10 92609385 92609509 125 + 2.207 2.048 -0.532
ENSG00000138160 E011 161.7233257 0.0016646481 3.392067e-08 3.782547e-07 10 92613040 92613130 91 + 2.096 1.909 -0.628
ENSG00000138160 E012 304.5892574 0.0007026397 1.516551e-09 2.174255e-08 10 92613377 92613619 243 + 2.361 2.240 -0.406
ENSG00000138160 E013 190.1300269 0.0002739190 2.182555e-09 3.036585e-08 10 92616737 92616832 96 + 2.163 2.000 -0.543
ENSG00000138160 E014 178.9927107 0.0070166746 8.767069e-04 3.532767e-03 10 92621385 92621473 89 + 2.131 2.016 -0.385
ENSG00000138160 E015 176.1155340 0.0257096431 4.769257e-02 1.050716e-01 10 92628808 92628895 88 + 2.120 2.037 -0.279
ENSG00000138160 E016 244.0518495 0.0028350119 3.413556e-02 8.002772e-02 10 92630176 92630364 189 + 2.251 2.237 -0.045
ENSG00000138160 E017 2.5560380 0.0130486381 3.836923e-01 5.278897e-01 10 92632191 92632310 120 + 0.424 0.636 1.006
ENSG00000138160 E018 229.7330963 0.0007520538 1.256147e-01 2.280290e-01 10 92632486 92632693 208 + 2.220 2.239 0.064
ENSG00000138160 E019 213.2130518 0.0002383740 2.409662e-01 3.753027e-01 10 92633623 92633795 173 + 2.185 2.218 0.108
ENSG00000138160 E020 237.5690936 0.0001840540 2.954517e-04 1.361462e-03 10 92637184 92637309 126 + 2.244 2.197 -0.155
ENSG00000138160 E021 109.2021790 0.0002664583 3.737032e-04 1.672422e-03 10 92637387 92637390 4 + 1.918 1.814 -0.352
ENSG00000138160 E022 309.7548010 0.0001594347 1.421188e-03 5.377160e-03 10 92637391 92637545 155 + 2.355 2.337 -0.060
ENSG00000138160 E023 265.5111203 0.0001863604 8.956831e-01 9.373541e-01 10 92639794 92639900 107 + 2.274 2.349 0.251
ENSG00000138160 E024 405.8686158 0.0001516096 1.000245e-01 1.905203e-01 10 92645363 92645642 280 + 2.450 2.559 0.365
ENSG00000138160 E025 363.9317900 0.0001417182 6.839093e-02 1.407087e-01 10 92648212 92648434 223 + 2.402 2.517 0.385
ENSG00000138160 E026 425.5453522 0.0001899889 1.910596e-04 9.256967e-04 10 92649835 92649986 152 + 2.461 2.615 0.514
ENSG00000138160 E027 364.7051762 0.0001361735 1.441781e-04 7.216983e-04 10 92650401 92650517 117 + 2.393 2.554 0.537
ENSG00000138160 E028 1089.6245714 0.0140392130 2.778781e-11 5.384389e-10 10 92653665 92655395 1731 + 2.807 3.205 1.324