ENSG00000138138

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000308448 ENSG00000138138 HEK293_OSMI2_2hA HEK293_TMG_2hB ATAD1 protein_coding protein_coding 35.94016 9.329751 56.20232 0.6550402 0.9911166 2.58943 4.694437 2.00157463 7.878821 0.36388842 0.3082725 1.971484 0.15741250 0.2116667 0.14013333 -0.07153333 5.234349e-02 1.157129e-13 FALSE TRUE
ENST00000328142 ENSG00000138138 HEK293_OSMI2_2hA HEK293_TMG_2hB ATAD1 protein_coding protein_coding 35.94016 9.329751 56.20232 0.6550402 0.9911166 2.58943 12.224591 4.70260330 15.770163 0.32647880 1.2675699 1.743516 0.38791250 0.5055000 0.28006667 -0.22543333 2.194448e-05 1.157129e-13 FALSE TRUE
MSTRG.4320.2 ENSG00000138138 HEK293_OSMI2_2hA HEK293_TMG_2hB ATAD1 protein_coding   35.94016 9.329751 56.20232 0.6550402 0.9911166 2.58943 2.256091 0.01785673 4.687184 0.01785673 0.2989224 7.397626 0.05721667 0.0017000 0.08363333 0.08193333 1.157129e-13 1.157129e-13 TRUE TRUE
MSTRG.4320.7 ENSG00000138138 HEK293_OSMI2_2hA HEK293_TMG_2hB ATAD1 protein_coding   35.94016 9.329751 56.20232 0.6550402 0.9911166 2.58943 14.961646 2.04096996 24.934315 0.12274897 0.3533843 3.604333 0.33377500 0.2226333 0.44403333 0.22140000 1.077927e-05 1.157129e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000138138 E001 4.4370901 0.0036870779 9.125495e-01 9.485703e-01 10 87746196 87746532 337 - 0.664 0.655 -0.041
ENSG00000138138 E002 1.9917815 0.0174118086 8.040911e-01 8.753493e-01 10 87746686 87746806 121 - 0.424 0.381 -0.237
ENSG00000138138 E003 17.8707394 0.0009983967 1.612984e-01 2.767870e-01 10 87751512 87751877 366 - 1.159 1.300 0.501
ENSG00000138138 E004 157.1230395 0.0293309574 1.779742e-01 2.985918e-01 10 87751878 87753116 1239 - 2.070 2.236 0.553
ENSG00000138138 E005 165.3662772 0.0028209833 5.586239e-16 2.182954e-14 10 87753117 87753451 335 - 2.044 2.367 1.079
ENSG00000138138 E006 518.3983281 0.0002723453 3.833052e-17 1.733079e-15 10 87753452 87754379 928 - 2.586 2.749 0.541
ENSG00000138138 E007 344.5340377 0.0003768207 7.720933e-02 1.550184e-01 10 87754380 87754661 282 - 2.454 2.421 -0.111
ENSG00000138138 E008 212.4592987 0.0002153247 1.906301e-01 3.145454e-01 10 87754662 87754807 146 - 2.229 2.279 0.166
ENSG00000138138 E009 222.3004301 0.0001989976 8.558804e-01 9.108906e-01 10 87756789 87756922 134 - 2.258 2.264 0.020
ENSG00000138138 E010 2.8775925 0.0056761777 3.695287e-01 5.139349e-01 10 87759701 87759813 113 - 0.552 0.381 -0.865
ENSG00000138138 E011 6.4612731 0.0025758883 3.669878e-02 8.490327e-02 10 87766220 87766405 186 - 0.718 1.006 1.115
ENSG00000138138 E012 177.4291446 0.0002375429 7.895082e-01 8.652915e-01 10 87767673 87767723 51 - 2.156 2.176 0.065
ENSG00000138138 E013 180.4494021 0.0001977176 3.517431e-02 8.197400e-02 10 87770952 87771041 90 - 2.180 2.120 -0.201
ENSG00000138138 E014 237.3683927 0.0011209059 4.041143e-03 1.325750e-02 10 87776321 87776427 107 - 2.303 2.218 -0.285
ENSG00000138138 E015 3.0551311 0.0053115291 7.221039e-01 8.162998e-01 10 87778521 87778731 211 - 0.552 0.493 -0.280
ENSG00000138138 E016 206.0572703 0.0024198680 7.951772e-02 1.587731e-01 10 87784470 87784551 82 - 2.238 2.178 -0.199
ENSG00000138138 E017 244.5916466 0.0003746297 3.472653e-03 1.164623e-02 10 87784552 87784670 119 - 2.314 2.237 -0.257
ENSG00000138138 E018 2.5268692 0.0095892525 1.922386e-02 4.982267e-02 10 87789040 87789129 90 - 0.552 0.001 -10.367
ENSG00000138138 E019 235.4701595 0.0001900380 2.271055e-03 8.062751e-03 10 87790310 87790430 121 - 2.299 2.220 -0.264
ENSG00000138138 E020 252.3033150 0.0022640878 3.923768e-04 1.745436e-03 10 87792657 87792755 99 - 2.335 2.214 -0.404
ENSG00000138138 E021 278.6837917 0.0002274728 3.225636e-08 3.609705e-07 10 87814438 87814612 175 - 2.382 2.237 -0.487
ENSG00000138138 E022 0.8211642 0.1326065292 8.813921e-01 9.279908e-01 10 87814613 87814882 270 - 0.205 0.233 0.232
ENSG00000138138 E023 97.7032448 0.0011042865 5.898171e-02 1.248914e-01 10 87817795 87818160 366 - 1.921 1.840 -0.273
ENSG00000138138 E024 60.9013572 0.0004638814 1.981565e-04 9.559257e-04 10 87818167 87818226 60 - 1.738 1.514 -0.762
ENSG00000138138 E025 0.0000000       10 87841187 87841361 175 -