ENSG00000138107

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000369905 ENSG00000138107 HEK293_OSMI2_2hA HEK293_TMG_2hB ACTR1A protein_coding protein_coding 155.1771 264.225 96.36888 11.40854 0.7828291 -1.455033 130.650529 237.132893 69.232583 5.422217 0.2116356 -1.7760252 0.8122167 0.899066667 0.71850000 -0.18056667 4.205710e-06 5.448637e-46 FALSE TRUE
MSTRG.4552.7 ENSG00000138107 HEK293_OSMI2_2hA HEK293_TMG_2hB ACTR1A protein_coding   155.1771 264.225 96.36888 11.40854 0.7828291 -1.455033 3.852688 1.237063 7.637853 1.237063 0.7290219 2.6165203 0.0365250 0.004333333 0.07926667 0.07493333 2.318682e-02 5.448637e-46 FALSE TRUE
MSTRG.4552.9 ENSG00000138107 HEK293_OSMI2_2hA HEK293_TMG_2hB ACTR1A protein_coding   155.1771 264.225 96.36888 11.40854 0.7828291 -1.455033 12.775419 12.979468 16.022669 4.245441 0.3630258 0.3036724 0.1020000 0.047933333 0.16626667 0.11833333 2.964391e-04 5.448637e-46 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000138107 E001 0.737403 0.0153787590 8.612564e-03 2.531839e-02 10 102461881 102462060 180 - 0.519 0.073 -3.651
ENSG00000138107 E002 1.260631 0.1347055201 4.121251e-01 5.556724e-01 10 102472835 102472981 147 - 0.436 0.279 -0.939
ENSG00000138107 E003 10.945573 0.0015595319 1.971541e-01 3.226747e-01 10 102478860 102479074 215 - 1.098 0.967 -0.480
ENSG00000138107 E004 12.657100 0.0046135687 4.358232e-01 5.779841e-01 10 102479075 102479228 154 - 1.117 1.045 -0.263
ENSG00000138107 E005 9.940639 0.0159321786 6.004097e-01 7.216459e-01 10 102479229 102479229 1 - 0.898 0.982 0.312
ENSG00000138107 E006 31.563400 0.0032260086 4.035883e-02 9.167807e-02 10 102479230 102479236 7 - 1.276 1.458 0.634
ENSG00000138107 E007 5746.614642 0.0015511576 1.106416e-16 4.728335e-15 10 102479237 102480478 1242 - 3.543 3.697 0.512
ENSG00000138107 E008 261.309518 0.0079997487 3.237185e-02 7.657762e-02 10 102480479 102480482 4 - 2.229 2.351 0.408
ENSG00000138107 E009 285.092841 0.0045136735 8.786426e-03 2.574928e-02 10 102480483 102480492 10 - 2.266 2.389 0.412
ENSG00000138107 E010 1758.432134 0.0002340831 5.881769e-08 6.243883e-07 10 102480493 102480794 302 - 3.090 3.170 0.265
ENSG00000138107 E011 1987.524288 0.0006760777 1.018853e-01 1.933667e-01 10 102480795 102480965 171 - 3.178 3.216 0.126
ENSG00000138107 E012 1216.353462 0.0005057146 3.075436e-01 4.497770e-01 10 102481132 102481172 41 - 2.972 3.001 0.097
ENSG00000138107 E013 1372.096148 0.0003169345 4.832379e-02 1.062017e-01 10 102481837 102481898 62 - 3.015 3.056 0.135
ENSG00000138107 E014 2216.383720 0.0001880034 1.702520e-01 2.885026e-01 10 102482001 102482175 175 - 3.234 3.261 0.090
ENSG00000138107 E015 51.604604 0.0035144931 7.670051e-07 6.532760e-06 10 102482176 102483010 835 - 1.832 1.551 -0.953
ENSG00000138107 E016 931.186302 0.0001316472 3.273152e-01 4.707485e-01 10 102483011 102483013 3 - 2.880 2.878 -0.008
ENSG00000138107 E017 1661.701899 0.0001418412 9.617981e-03 2.782423e-02 10 102483014 102483103 90 - 3.144 3.126 -0.058
ENSG00000138107 E018 20.721973 0.0009144578 2.453970e-04 1.156144e-03 10 102483104 102483680 577 - 1.457 1.175 -0.986
ENSG00000138107 E019 6.346169 0.0735426248 6.614598e-02 1.369555e-01 10 102484074 102484159 86 - 1.010 0.693 -1.232
ENSG00000138107 E020 2328.241417 0.0011884775 2.358446e-03 8.333809e-03 10 102484160 102484376 217 - 3.309 3.268 -0.136
ENSG00000138107 E021 1668.772422 0.0011966712 4.570590e-05 2.600254e-04 10 102485609 102485733 125 - 3.182 3.118 -0.213
ENSG00000138107 E022 1845.285606 0.0005752431 8.941933e-08 9.159353e-07 10 102488150 102488272 123 - 3.226 3.161 -0.215
ENSG00000138107 E023 879.074696 0.0006477157 2.895471e-08 3.269001e-07 10 102488273 102488275 3 - 2.921 2.832 -0.295
ENSG00000138107 E024 1484.470286 0.0010095221 6.016466e-09 7.743216e-08 10 102489063 102489138 76 - 3.152 3.060 -0.307
ENSG00000138107 E025 1118.699269 0.0023320066 7.463149e-06 5.103307e-05 10 102490549 102490613 65 - 3.037 2.935 -0.341
ENSG00000138107 E026 1066.701305 0.0024054859 6.427593e-06 4.464648e-05 10 102502600 102502834 235 - 3.019 2.913 -0.351