ENSG00000138101

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000288642 ENSG00000138101 HEK293_OSMI2_2hA HEK293_TMG_2hB DTNB protein_coding protein_coding 12.44439 16.90515 11.93344 0.5560149 0.7223914 -0.5020971 2.7181773 4.4688767 1.993239 0.66827798 1.0026235 -1.1608023 0.21825833 0.2631667 0.1622000 -0.10096667 0.740394533 0.001295549 FALSE  
ENST00000407186 ENSG00000138101 HEK293_OSMI2_2hA HEK293_TMG_2hB DTNB protein_coding protein_coding 12.44439 16.90515 11.93344 0.5560149 0.7223914 -0.5020971 0.9424030 0.7010565 1.178934 0.35582371 0.7751458 0.7416322 0.07898333 0.0423000 0.1045000 0.06220000 0.808651718 0.001295549 FALSE  
ENST00000493538 ENSG00000138101 HEK293_OSMI2_2hA HEK293_TMG_2hB DTNB protein_coding retained_intron 12.44439 16.90515 11.93344 0.5560149 0.7223914 -0.5020971 0.7156215 0.5921657 1.319894 0.17990504 0.1541502 1.1430793 0.06219167 0.0346000 0.1099000 0.07530000 0.001295549 0.001295549 TRUE  
MSTRG.18074.9 ENSG00000138101 HEK293_OSMI2_2hA HEK293_TMG_2hB DTNB protein_coding   12.44439 16.90515 11.93344 0.5560149 0.7223914 -0.5020971 6.1497137 8.8400952 5.208625 0.05026291 0.3994947 -0.7620232 0.48210000 0.5239000 0.4357333 -0.08816667 0.054828774 0.001295549 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000138101 E001 1.1510600 0.0126241731 7.670211e-01 8.493628e-01 2 25377198 25377242 45 - 0.281 0.335 0.354
ENSG00000138101 E002 1.0361780 0.0207891212 9.738694e-01 9.877116e-01 2 25377243 25377244 2 - 0.281 0.286 0.035
ENSG00000138101 E003 5.8726328 0.0543578755 8.539863e-01 9.096515e-01 2 25377245 25377257 13 - 0.778 0.807 0.115
ENSG00000138101 E004 10.4271735 0.0031509765 2.020364e-01 3.287428e-01 2 25377258 25377283 26 - 0.918 1.060 0.526
ENSG00000138101 E005 10.9774850 0.0038471170 1.885377e-01 3.118977e-01 2 25377284 25377289 6 - 0.941 1.085 0.531
ENSG00000138101 E006 19.7140482 0.0011226911 5.600184e-02 1.196974e-01 2 25377290 25377312 23 - 1.166 1.327 0.569
ENSG00000138101 E007 117.6807230 0.0010872484 2.995961e-03 1.025190e-02 2 25377313 25377553 241 - 1.957 2.069 0.375
ENSG00000138101 E008 76.0078278 0.0004835049 7.191159e-02 1.465122e-01 2 25379290 25379323 34 - 1.792 1.870 0.262
ENSG00000138101 E009 4.1149755 0.0066772520 5.378694e-01 6.693626e-01 2 25379324 25379913 590 - 0.744 0.652 -0.381
ENSG00000138101 E010 1.2167234 0.0105979102 2.431192e-01 3.778483e-01 2 25383683 25383835 153 - 0.163 0.380 1.619
ENSG00000138101 E011 32.4925494 0.0007321021 3.183107e-01 4.612802e-01 2 25383836 25383889 54 - 1.437 1.502 0.221
ENSG00000138101 E012 2.0648542 0.0072255493 5.068551e-01 6.424908e-01 2 25386027 25386095 69 - 0.374 0.491 0.619
ENSG00000138101 E013 0.1515154 0.0427022795 2.556300e-01   2 25387194 25387223 30 - 0.163 0.000 -11.154
ENSG00000138101 E014 0.8210624 0.1000265430 7.862558e-01 8.631001e-01 2 25387224 25387288 65 - 0.281 0.229 -0.389
ENSG00000138101 E015 99.7223479 0.0037316299 1.128976e-01 2.097731e-01 2 25387289 25387378 90 - 1.911 1.983 0.241
ENSG00000138101 E016 88.3028412 0.0003988436 1.614682e-01 2.770176e-01 2 25388202 25388260 59 - 1.873 1.928 0.186
ENSG00000138101 E017 83.1882260 0.0003774906 3.260775e-03 1.103469e-02 2 25388261 25388317 57 - 1.798 1.922 0.418
ENSG00000138101 E018 68.7833954 0.0009201364 4.305810e-03 1.399998e-02 2 25388318 25388361 44 - 1.708 1.844 0.461
ENSG00000138101 E019 0.8783198 0.0136966248 4.961872e-01 6.329066e-01 2 25388362 25388640 279 - 0.163 0.286 1.035
ENSG00000138101 E020 1.1102619 0.0124885631 6.259309e-01 7.419643e-01 2 25419102 25419514 413 - 0.374 0.286 -0.553
ENSG00000138101 E021 4.3135023 0.0040127482 2.856742e-01 4.260286e-01 2 25419515 25419535 21 - 0.572 0.734 0.697
ENSG00000138101 E022 96.9594833 0.0024030865 1.745597e-02 4.594696e-02 2 25427535 25427631 97 - 1.876 1.980 0.351
ENSG00000138101 E023 4.1317133 0.0129618549 6.267919e-01 7.426829e-01 2 25427632 25428016 385 - 0.744 0.673 -0.295
ENSG00000138101 E024 93.1640796 0.0003429426 4.189162e-01 5.621802e-01 2 25432886 25432999 114 - 1.916 1.946 0.100
ENSG00000138101 E025 90.4799364 0.0003169199 5.522810e-02 1.183804e-01 2 25433910 25433995 86 - 1.871 1.946 0.253
ENSG00000138101 E026 79.7154919 0.0010388977 9.357199e-02 1.807064e-01 2 25451548 25451635 88 - 1.820 1.893 0.247
ENSG00000138101 E027 81.1749647 0.0003797825 3.861385e-02 8.847492e-02 2 25455405 25455494 90 - 1.820 1.906 0.291
ENSG00000138101 E028 0.0000000       2 25481601 25481845 245 -      
ENSG00000138101 E029 85.6692113 0.0003709206 3.071060e-01 4.492990e-01 2 25482796 25482873 78 - 1.876 1.916 0.135
ENSG00000138101 E030 0.0000000       2 25497298 25497301 4 -      
ENSG00000138101 E031 0.0000000       2 25497302 25497591 290 -      
ENSG00000138101 E032 0.0000000       2 25497592 25497651 60 -      
ENSG00000138101 E033 104.2436069 0.0004785001 3.958477e-01 5.396323e-01 2 25531473 25531597 125 - 1.968 1.998 0.102
ENSG00000138101 E034 5.4868167 0.1154009920 4.575236e-01 5.978595e-01 2 25576516 25576563 48 - 0.895 0.727 -0.661
ENSG00000138101 E035 11.6052073 0.0233488053 1.449823e-04 7.253509e-04 2 25576564 25576828 265 - 1.332 0.896 -1.574
ENSG00000138101 E036 4.5746975 0.0040893261 3.305453e-04 1.502923e-03 2 25576829 25576837 9 - 1.004 0.522 -1.968
ENSG00000138101 E037 127.6555233 0.0044957803 6.462477e-01 7.582194e-01 2 25576838 25576952 115 - 2.089 2.067 -0.074
ENSG00000138101 E038 86.9699184 0.0003108274 2.289701e-01 3.612186e-01 2 25576953 25577004 52 - 1.942 1.892 -0.166
ENSG00000138101 E039 112.0600385 0.0002872758 1.027705e-01 1.947210e-01 2 25580721 25580826 106 - 2.056 1.998 -0.196
ENSG00000138101 E040 0.8898489 0.1959529631 1.631480e-01 2.792597e-01 2 25594889 25595188 300 - 0.450 0.163 -1.997
ENSG00000138101 E041 79.5010390 0.0003870141 5.419503e-01 6.728191e-01 2 25596086 25596123 38 - 1.886 1.859 -0.092
ENSG00000138101 E042 110.0832139 0.0003156266 5.533101e-01 6.824810e-01 2 25596124 25596240 117 - 2.024 2.001 -0.077
ENSG00000138101 E043 0.1515154 0.0427022795 2.556300e-01   2 25596241 25596456 216 - 0.163 0.000 -11.154
ENSG00000138101 E044 0.0000000       2 25598803 25599043 241 -      
ENSG00000138101 E045 84.3108621 0.0004804695 6.121104e-01 7.311217e-01 2 25607236 25607286 51 - 1.881 1.900 0.064
ENSG00000138101 E046 90.6994538 0.0007650389 7.674659e-02 1.542823e-01 2 25607287 25607321 35 - 1.974 1.901 -0.245
ENSG00000138101 E047 81.5040286 0.0015455142 1.825369e-03 6.681428e-03 2 25628171 25628182 12 - 1.972 1.835 -0.460
ENSG00000138101 E048 164.6781491 0.0002910440 2.812844e-08 3.183873e-07 2 25628183 25628384 202 - 2.288 2.131 -0.526
ENSG00000138101 E049 91.2901349 0.0003288905 3.184005e-04 1.454441e-03 2 25639014 25639094 81 - 2.020 1.882 -0.464
ENSG00000138101 E050 0.0000000       2 25639095 25639328 234 -      
ENSG00000138101 E051 0.1472490 0.0425863930 2.559254e-01   2 25649837 25650021 185 - 0.163 0.000 -11.153
ENSG00000138101 E052 0.0000000       2 25650022 25650222 201 -      
ENSG00000138101 E053 71.5932887 0.0032898119 2.863462e-01 4.267419e-01 2 25652594 25652661 68 - 1.862 1.804 -0.196
ENSG00000138101 E054 0.0000000       2 25652925 25653180 256 -      
ENSG00000138101 E055 0.2924217 0.0290785164 7.551148e-02   2 25672780 25672946 167 - 0.281 0.000 -12.153
ENSG00000138101 E056 57.2457322 0.0117081994 1.447354e-01 2.544703e-01 2 25673386 25673647 262 - 1.801 1.691 -0.371