ENSG00000138092

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000260662 ENSG00000138092 HEK293_OSMI2_2hA HEK293_TMG_2hB CENPO protein_coding protein_coding 28.10438 33.52479 25.03749 2.10869 0.5950727 -0.4209923 3.671365 5.85341113 2.822977 0.96357347 0.7432579 -1.0494211 0.12833750 0.173433333 0.11416667 -0.05926667 0.505509100 0.005484565 FALSE TRUE
ENST00000380834 ENSG00000138092 HEK293_OSMI2_2hA HEK293_TMG_2hB CENPO protein_coding protein_coding 28.10438 33.52479 25.03749 2.10869 0.5950727 -0.4209923 11.303364 16.00613493 6.693955 1.24923808 0.6426485 -1.2564417 0.39397083 0.479866667 0.26763333 -0.21223333 0.005514286 0.005484565 FALSE TRUE
ENST00000473706 ENSG00000138092 HEK293_OSMI2_2hA HEK293_TMG_2hB CENPO protein_coding protein_coding 28.10438 33.52479 25.03749 2.10869 0.5950727 -0.4209923 6.106086 7.09542199 5.949031 0.38695677 0.5567326 -0.2538427 0.21657500 0.212533333 0.23696667 0.02443333 0.713826261 0.005484565 FALSE TRUE
ENST00000498362 ENSG00000138092 HEK293_OSMI2_2hA HEK293_TMG_2hB CENPO protein_coding processed_transcript 28.10438 33.52479 25.03749 2.10869 0.5950727 -0.4209923 1.722650 0.67106745 2.491068 0.67106745 0.5767545 1.8766745 0.06666667 0.017800000 0.09863333 0.08083333 0.097323498 0.005484565 TRUE FALSE
MSTRG.18069.8 ENSG00000138092 HEK293_OSMI2_2hA HEK293_TMG_2hB CENPO protein_coding   28.10438 33.52479 25.03749 2.10869 0.5950727 -0.4209923 1.009643 0.08840833 1.635755 0.08840833 0.3101528 4.0638252 0.03908750 0.002766667 0.06543333 0.06266667 0.005484565 0.005484565 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000138092 E001 0.7728905 0.0153787590 5.607231e-02 1.198291e-01 2 24793136 24793144 9 + 0.424 0.099 -2.696
ENSG00000138092 E002 5.3318892 0.0031086686 2.983909e-01 4.398274e-01 2 24793145 24793164 20 + 0.858 0.728 -0.515
ENSG00000138092 E003 19.9490642 0.0012211710 3.127662e-03 1.064068e-02 2 24793165 24793305 141 + 1.426 1.207 -0.767
ENSG00000138092 E004 25.3194623 0.0009936158 1.418363e-03 5.367974e-03 2 24793306 24793399 94 + 1.523 1.310 -0.733
ENSG00000138092 E005 15.7758981 0.0122532899 6.423621e-02 1.337615e-01 2 24793400 24793424 25 + 1.311 1.139 -0.609
ENSG00000138092 E006 18.8396572 0.0026516503 1.796455e-02 4.705867e-02 2 24793425 24793444 20 + 1.384 1.200 -0.644
ENSG00000138092 E007 45.8874093 0.0004930789 2.526477e-05 1.530110e-04 2 24793445 24793461 17 + 1.771 1.560 -0.717
ENSG00000138092 E008 46.8816433 0.0004910130 3.519219e-05 2.056354e-04 2 24793462 24793462 1 + 1.777 1.572 -0.696
ENSG00000138092 E009 62.8665395 0.0011758685 5.590668e-05 3.111992e-04 2 24793463 24793476 14 + 1.888 1.707 -0.611
ENSG00000138092 E010 63.2126512 0.0005867613 9.661609e-07 8.039896e-06 2 24793477 24793477 1 + 1.908 1.695 -0.718
ENSG00000138092 E011 109.7081053 0.0027330884 7.285050e-04 3.001394e-03 2 24793478 24793501 24 + 2.101 1.968 -0.446
ENSG00000138092 E012 25.7182928 0.0153303236 1.739261e-01 2.932895e-01 2 24793502 24793520 19 + 1.472 1.355 -0.402
ENSG00000138092 E013 91.0334344 0.0048146929 7.553397e-02 1.523685e-01 2 24793852 24793965 114 + 1.989 1.910 -0.266
ENSG00000138092 E014 210.9781142 0.0008795951 2.346694e-03 8.297389e-03 2 24799675 24799844 170 + 2.350 2.274 -0.255
ENSG00000138092 E015 198.0011327 0.0002062709 7.896984e-05 4.230101e-04 2 24814376 24814493 118 + 2.333 2.240 -0.312
ENSG00000138092 E016 2.0680685 0.0068638862 2.458823e-04 1.158161e-03 2 24814494 24814782 289 + 0.776 0.179 -3.283
ENSG00000138092 E017 172.7000338 0.0002565973 6.186850e-04 2.601905e-03 2 24815497 24815597 101 + 2.269 2.182 -0.290
ENSG00000138092 E018 156.0676552 0.0005933438 9.396846e-03 2.727279e-02 2 24815598 24815624 27 + 2.215 2.144 -0.238
ENSG00000138092 E019 203.9234271 0.0014224914 2.891607e-02 6.983761e-02 2 24815625 24815699 75 + 2.323 2.264 -0.196
ENSG00000138092 E020 172.9224512 0.0002272149 4.321505e-02 9.694564e-02 2 24815700 24815756 57 + 2.248 2.201 -0.159
ENSG00000138092 E021 18.1781399 0.0129535216 1.094861e-05 7.208025e-05 2 24815757 24816571 815 + 1.489 1.085 -1.419
ENSG00000138092 E022 176.4609231 0.0002198956 1.567563e-01 2.707705e-01 2 24816646 24816730 85 + 2.246 2.216 -0.102
ENSG00000138092 E023 148.8577643 0.0022169354 9.950857e-01 1.000000e+00 2 24816731 24816758 28 + 2.148 2.158 0.033
ENSG00000138092 E024 165.4917576 0.0033692718 9.761768e-01 9.891020e-01 2 24816759 24816817 59 + 2.194 2.203 0.028
ENSG00000138092 E025 247.7741062 0.0002077745 2.884384e-01 4.290357e-01 2 24817670 24817841 172 + 2.384 2.368 -0.054
ENSG00000138092 E026 1693.4013216 0.0001400832 1.365226e-10 2.355966e-09 2 24819354 24821642 2289 + 3.163 3.225 0.204
ENSG00000138092 E027 605.4678871 0.0008748407 2.734960e-31 5.006087e-29 2 24821643 24822376 734 + 2.584 2.826 0.806
ENSG00000138092 E028 13.1172100 0.0020911286 7.176387e-01 8.129500e-01 2 24822507 24822568 62 + 1.141 1.115 -0.096