ENSG00000138078

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000409411 ENSG00000138078 HEK293_OSMI2_2hA HEK293_TMG_2hB PREPL protein_coding protein_coding 22.46171 6.413267 37.87254 0.5497218 0.9493386 2.560154 2.4452785 0.47791713 4.196846 0.10880569 0.1130815 3.108031 0.10213750 0.073033333 0.11106667 0.03803333 2.144557e-01 4.373251e-15 FALSE TRUE
ENST00000409936 ENSG00000138078 HEK293_OSMI2_2hA HEK293_TMG_2hB PREPL protein_coding protein_coding 22.46171 6.413267 37.87254 0.5497218 0.9493386 2.560154 5.1785134 1.08776962 8.625105 0.14959309 0.4236206 2.975638 0.22349167 0.175766667 0.22746667 0.05170000 5.191396e-01 4.373251e-15 FALSE TRUE
ENST00000409957 ENSG00000138078 HEK293_OSMI2_2hA HEK293_TMG_2hB PREPL protein_coding protein_coding 22.46171 6.413267 37.87254 0.5497218 0.9493386 2.560154 6.5037288 4.18171581 9.079441 0.62604497 0.6369969 1.116651 0.38844583 0.645166667 0.24013333 -0.40503333 1.537190e-10 4.373251e-15 FALSE TRUE
MSTRG.18319.1 ENSG00000138078 HEK293_OSMI2_2hA HEK293_TMG_2hB PREPL protein_coding   22.46171 6.413267 37.87254 0.5497218 0.9493386 2.560154 0.8592013 0.00000000 2.606612 0.00000000 1.4065631 8.031556 0.02639583 0.000000000 0.06756667 0.06756667 3.839561e-01 4.373251e-15 TRUE TRUE
MSTRG.18319.10 ENSG00000138078 HEK293_OSMI2_2hA HEK293_TMG_2hB PREPL protein_coding   22.46171 6.413267 37.87254 0.5497218 0.9493386 2.560154 3.8211336 0.01853562 7.045212 0.01853562 0.7086872 7.949782 0.10157500 0.003033333 0.18616667 0.18313333 4.373251e-15 4.373251e-15 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000138078 E001 0.8963053 0.1582841437 4.069213e-01 5.505557e-01 2 44316281 44316444 164 - 0.189 0.403 1.484
ENSG00000138078 E002 0.0000000       2 44317607 44317609 3 -      
ENSG00000138078 E003 0.0000000       2 44317610 44317610 1 -      
ENSG00000138078 E004 13.0825301 0.0015322016 8.751454e-03 2.566329e-02 2 44317611 44318389 779 - 0.956 1.293 1.215
ENSG00000138078 E005 1.3652201 0.0110787869 1.720027e-01 2.908085e-01 2 44318390 44318762 373 - 0.226 0.523 1.778
ENSG00000138078 E006 2.8700090 0.0063435844 1.232813e-07 1.230585e-06 2 44318763 44318765 3 - 0.189 1.045 4.212
ENSG00000138078 E007 115.9424268 0.0104991232 4.079079e-27 5.314781e-25 2 44318766 44319005 240 - 1.711 2.433 2.420
ENSG00000138078 E008 690.2031863 0.0084902873 1.096387e-10 1.921613e-09 2 44319006 44320265 1260 - 2.641 2.975 1.111
ENSG00000138078 E009 273.2870962 0.0002336582 6.906004e-02 1.418158e-01 2 44320266 44320643 378 - 2.316 2.335 0.064
ENSG00000138078 E010 136.2581643 0.0009722485 7.376004e-01 8.277180e-01 2 44320644 44320826 183 - 2.003 2.085 0.275
ENSG00000138078 E011 89.2699999 0.0009732300 1.328436e-02 3.657969e-02 2 44320827 44320921 95 - 1.800 1.985 0.622
ENSG00000138078 E012 77.3629085 0.0009415412 1.833629e-01 3.054307e-01 2 44320922 44321012 91 - 1.751 1.887 0.461
ENSG00000138078 E013 96.3203888 0.0003079109 4.232867e-02 9.532290e-02 2 44321013 44321067 55 - 1.840 1.999 0.535
ENSG00000138078 E014 74.6995441 0.0004999916 2.783718e-02 6.769449e-02 2 44321068 44321072 5 - 1.726 1.905 0.603
ENSG00000138078 E015 238.5607225 0.0006668149 9.306213e-02 1.799125e-01 2 44321073 44321445 373 - 2.239 2.360 0.404
ENSG00000138078 E016 6.0583259 0.0030370325 3.463907e-01 4.905268e-01 2 44321464 44321826 363 - 0.706 0.903 0.775
ENSG00000138078 E017 111.2972439 0.0002525179 8.936789e-02 1.741640e-01 2 44321827 44321900 74 - 1.934 1.929 -0.016
ENSG00000138078 E018 158.0526446 0.0002917459 1.024793e-03 4.043908e-03 2 44322731 44322854 124 - 2.093 2.038 -0.184
ENSG00000138078 E019 172.9164161 0.0003157320 2.306348e-02 5.788389e-02 2 44323262 44323411 150 - 2.125 2.114 -0.037
ENSG00000138078 E020 205.7853914 0.0002105824 4.626490e-01 6.025123e-01 2 44326712 44326928 217 - 2.189 2.236 0.157
ENSG00000138078 E021 216.1139314 0.0002456656 1.112667e-04 5.735821e-04 2 44328937 44329112 176 - 2.228 2.172 -0.187
ENSG00000138078 E022 239.0622541 0.0002135934 1.034262e-07 1.047572e-06 2 44332459 44332656 198 - 2.277 2.179 -0.328
ENSG00000138078 E023 190.8242462 0.0002193944 5.226075e-07 4.605164e-06 2 44338351 44338536 186 - 2.182 2.073 -0.363
ENSG00000138078 E024 195.4180923 0.0003770456 3.335575e-10 5.384872e-09 2 44339147 44339363 217 - 2.199 2.038 -0.540
ENSG00000138078 E025 151.5895139 0.0002250787 1.239071e-08 1.502133e-07 2 44342417 44342552 136 - 2.089 1.925 -0.550
ENSG00000138078 E026 102.8438496 0.0004830544 1.121426e-04 5.776732e-04 2 44343745 44343804 60 - 1.916 1.795 -0.408
ENSG00000138078 E027 122.0739278 0.0002922253 1.503351e-05 9.594252e-05 2 44343805 44343907 103 - 1.990 1.865 -0.420
ENSG00000138078 E028 90.0315840 0.0003391375 1.973806e-04 9.526192e-04 2 44343908 44343951 44 - 1.861 1.737 -0.418
ENSG00000138078 E029 86.2020929 0.0003142566 4.174562e-07 3.750988e-06 2 44344520 44344586 67 - 1.853 1.641 -0.718
ENSG00000138078 E030 66.7201557 0.0004237855 2.307548e-05 1.410188e-04 2 44346268 44346298 31 - 1.742 1.547 -0.665
ENSG00000138078 E031 131.1451240 0.0072908212 4.248325e-06 3.070707e-05 2 44346299 44346390 92 - 2.034 1.812 -0.747
ENSG00000138078 E032 0.5932625 0.1892069096 5.987169e-01 7.202724e-01 2 44347210 44347323 114 - 0.189 0.000 -9.861
ENSG00000138078 E033 0.1515154 0.0436591589 1.000000e+00   2 44356231 44356368 138 - 0.055 0.000 -7.860
ENSG00000138078 E034 35.2633324 0.0134934130 1.305552e-02 3.604122e-02 2 44359497 44359596 100 - 1.470 1.277 -0.669
ENSG00000138078 E035 32.9151076 0.0006775602 7.482216e-03 2.246728e-02 2 44359597 44359750 154 - 1.438 1.276 -0.564
ENSG00000138078 E036 30.7228237 0.0006582907 3.215318e-04 1.467082e-03 2 44359751 44360038 288 - 1.423 1.153 -0.947
ENSG00000138078 E037 15.4819493 0.0011724236 8.131590e-01 8.815312e-01 2 44360039 44360618 580 - 1.085 1.176 0.325
ENSG00000138078 E038 8.3509587 0.0020107818 9.288084e-02 1.796371e-01 2 44360619 44360676 58 - 0.800 1.075 1.034
ENSG00000138078 E039 75.3899859 0.0044619903 1.744262e-05 1.096513e-04 2 44361380 44361416 37 - 1.798 1.574 -0.762
ENSG00000138078 E040 78.9161201 0.0032102982 5.407740e-05 3.021085e-04 2 44361417 44361523 107 - 1.813 1.625 -0.637
ENSG00000138078 E041 23.5207869 0.0388229769 4.919706e-01 6.291935e-01 2 44361524 44361862 339 - 1.279 1.244 -0.124