ENSG00000138074

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000310574 ENSG00000138074 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC5A6 protein_coding protein_coding 83.11924 91.56904 66.87517 5.968311 3.258577 -0.4533312 44.715693 62.4415897 26.669318 2.79413787 0.3073403 -1.2270165 0.53008333 0.684000000 0.40043333 -0.28356667 1.780074e-13 7.987833e-38 FALSE TRUE
ENST00000445802 ENSG00000138074 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC5A6 protein_coding nonsense_mediated_decay 83.11924 91.56904 66.87517 5.968311 3.258577 -0.4533312 11.816087 9.9347640 11.616162 0.77104848 1.1281451 0.2253659 0.14413333 0.108333333 0.17323333 0.06490000 5.272011e-04 7.987833e-38 TRUE TRUE
ENST00000461757 ENSG00000138074 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC5A6 protein_coding retained_intron 83.11924 91.56904 66.87517 5.968311 3.258577 -0.4533312 4.770906 3.5463337 5.397595 0.38301163 0.3605127 0.6045964 0.05846250 0.038766667 0.08066667 0.04190000 7.387137e-06 7.987833e-38 FALSE FALSE
ENST00000476319 ENSG00000138074 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC5A6 protein_coding retained_intron 83.11924 91.56904 66.87517 5.968311 3.258577 -0.4533312 3.394351 0.7853199 5.492168 0.09508993 0.4286852 2.7903930 0.04204167 0.008633333 0.08186667 0.07323333 7.987833e-38 7.987833e-38 FALSE FALSE
MSTRG.18114.10 ENSG00000138074 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC5A6 protein_coding   83.11924 91.56904 66.87517 5.968311 3.258577 -0.4533312 8.509469 9.0254100 5.656850 1.93193389 0.3903887 -0.6730432 0.10177500 0.097333333 0.08536667 -0.01196667 8.555847e-01 7.987833e-38 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000138074 E001 7.0276633 0.0024603944 9.090604e-07 7.614909e-06 2 27199587 27199588 2 - 0.162 1.005 4.335
ENSG00000138074 E002 7.5393652 0.0025143133 2.904014e-07 2.695262e-06 2 27199589 27199592 4 - 0.162 1.035 4.441
ENSG00000138074 E003 17.8676532 0.0010898312 1.800452e-03 6.601066e-03 2 27199593 27199594 2 - 1.002 1.310 1.103
ENSG00000138074 E004 119.6912923 0.0029178203 1.640541e-03 6.091045e-03 2 27199595 27199617 23 - 1.930 2.086 0.522
ENSG00000138074 E005 390.7462096 0.0048644009 4.727509e-07 4.201218e-06 2 27199618 27199716 99 - 2.391 2.610 0.729
ENSG00000138074 E006 321.1260947 0.0060377501 7.656654e-05 4.118012e-04 2 27199717 27199719 3 - 2.327 2.520 0.643
ENSG00000138074 E007 667.9828378 0.0050753128 4.607168e-06 3.306991e-05 2 27199720 27199807 88 - 2.645 2.836 0.635
ENSG00000138074 E008 562.8202670 0.0048916558 4.574286e-05 2.601888e-04 2 27199808 27199837 30 - 2.586 2.758 0.571
ENSG00000138074 E009 1175.0146349 0.0024886961 3.206988e-12 7.245728e-11 2 27199838 27200104 267 - 2.884 3.083 0.661
ENSG00000138074 E010 1073.3222751 0.0002382765 9.238685e-18 4.562672e-16 2 27200105 27200435 331 - 2.895 3.027 0.438
ENSG00000138074 E011 695.3243967 0.0001219055 1.176213e-11 2.420487e-10 2 27200436 27200579 144 - 2.717 2.835 0.393
ENSG00000138074 E012 591.5599301 0.0001307810 6.705024e-06 4.637460e-05 2 27200998 27201101 104 - 2.667 2.755 0.292
ENSG00000138074 E013 338.7189513 0.0001668047 4.235623e-02 9.537022e-02 2 27201102 27201113 12 - 2.449 2.505 0.188
ENSG00000138074 E014 65.9083566 0.0004183426 5.446865e-29 8.382553e-27 2 27201114 27201349 236 - 2.056 1.577 -1.614
ENSG00000138074 E015 478.4738190 0.0001214569 4.659715e-02 1.031140e-01 2 27201350 27201411 62 - 2.605 2.654 0.162
ENSG00000138074 E016 438.0658040 0.0001600397 1.634032e-01 2.796005e-01 2 27201412 27201453 42 - 2.573 2.612 0.131
ENSG00000138074 E017 45.5563115 0.0072259832 1.580424e-19 9.574883e-18 2 27201454 27201665 212 - 1.946 1.359 -2.001
ENSG00000138074 E018 471.2733117 0.0011516368 4.251929e-01 5.681365e-01 2 27201666 27201711 46 - 2.610 2.644 0.111
ENSG00000138074 E019 470.4671320 0.0012063445 4.452662e-01 5.868251e-01 2 27201712 27201783 72 - 2.611 2.643 0.108
ENSG00000138074 E020 373.6638772 0.0001589079 6.844651e-01 7.874334e-01 2 27201784 27201847 64 - 2.518 2.539 0.070
ENSG00000138074 E021 8.3425316 0.0383086884 1.492427e-02 4.031768e-02 2 27201848 27201987 140 - 1.121 0.797 -1.215
ENSG00000138074 E022 387.6686984 0.0001508125 1.500149e-01 2.616932e-01 2 27201988 27202074 87 - 2.519 2.561 0.138
ENSG00000138074 E023 357.9038857 0.0001731610 7.839329e-01 8.613986e-01 2 27202813 27202880 68 - 2.502 2.520 0.061
ENSG00000138074 E024 51.4823070 0.0061335342 1.107019e-20 7.693378e-19 2 27202881 27203158 278 - 1.987 1.422 -1.915
ENSG00000138074 E025 30.6789392 0.0072728319 1.198410e-17 5.816940e-16 2 27203159 27203232 74 - 1.793 1.165 -2.165
ENSG00000138074 E026 517.4658750 0.0010871014 3.015854e-02 7.227817e-02 2 27203233 27203345 113 - 2.699 2.664 -0.116
ENSG00000138074 E027 432.8054551 0.0005167363 6.993380e-03 2.120716e-02 2 27203779 27203867 89 - 2.626 2.583 -0.143
ENSG00000138074 E028 440.3525174 0.0001944190 1.014522e-02 2.912136e-02 2 27204461 27204590 130 - 2.627 2.592 -0.119
ENSG00000138074 E029 4.9863177 0.0551269292 1.395949e-05 8.969253e-05 2 27204591 27204672 82 - 1.106 0.383 -3.057
ENSG00000138074 E030 416.8311875 0.0013451588 5.770543e-03 1.801008e-02 2 27204791 27204931 141 - 2.617 2.562 -0.183
ENSG00000138074 E031 32.9518104 0.0006036331 9.358079e-38 2.814064e-35 2 27204932 27205081 150 - 1.876 1.088 -2.722
ENSG00000138074 E032 34.1313521 0.0044575230 2.927210e-24 2.986275e-22 2 27205135 27205349 215 - 1.852 1.173 -2.336
ENSG00000138074 E033 272.1772997 0.0012073794 3.621253e-02 8.398858e-02 2 27205350 27205406 57 - 2.426 2.381 -0.150
ENSG00000138074 E034 198.0802044 0.0002081214 4.253133e-03 1.385057e-02 2 27205407 27205411 5 - 2.302 2.237 -0.216
ENSG00000138074 E035 415.7159413 0.0032504699 5.083771e-03 1.615840e-02 2 27205412 27205504 93 - 2.631 2.556 -0.253
ENSG00000138074 E036 386.7970517 0.0038627287 4.549661e-02 1.011037e-01 2 27206026 27206093 68 - 2.585 2.532 -0.178
ENSG00000138074 E037 11.6156637 0.0016070021 4.803304e-10 7.542242e-09 2 27206094 27206319 226 - 1.381 0.789 -2.162
ENSG00000138074 E038 328.8458093 0.0043940557 9.312639e-02 1.800110e-01 2 27206483 27206534 52 - 2.510 2.464 -0.155
ENSG00000138074 E039 247.1669343 0.0037092099 2.333418e-02 5.844714e-02 2 27206877 27206893 17 - 2.403 2.332 -0.238
ENSG00000138074 E040 340.7290134 0.0020397546 1.925445e-02 4.988782e-02 2 27206894 27206936 43 - 2.531 2.476 -0.182
ENSG00000138074 E041 233.6661849 0.0002520994 1.930351e-03 7.009787e-03 2 27206937 27206942 6 - 2.372 2.307 -0.220
ENSG00000138074 E042 301.6953425 0.0006897455 1.064665e-03 4.182950e-03 2 27207258 27207303 46 - 2.486 2.419 -0.225
ENSG00000138074 E043 399.9615548 0.0016663633 9.591180e-04 3.818714e-03 2 27207304 27207414 111 - 2.613 2.539 -0.247
ENSG00000138074 E044 285.2584391 0.0011985462 5.161651e-03 1.636831e-02 2 27207415 27207474 60 - 2.458 2.395 -0.211
ENSG00000138074 E045 261.2642357 0.0005561970 5.113796e-03 1.623994e-02 2 27207475 27207534 60 - 2.418 2.359 -0.195
ENSG00000138074 E046 206.9254574 0.0032541689 3.989191e-03 1.311230e-02 2 27207535 27207569 35 - 2.342 2.248 -0.315
ENSG00000138074 E047 609.3572076 0.0016164253 2.974632e-09 4.038521e-08 2 27207570 27207790 221 - 2.832 2.703 -0.428
ENSG00000138074 E048 4.8748975 0.0036986297 1.135697e-07 1.142069e-06 2 27208394 27208448 55 - 1.090 0.381 -3.008
ENSG00000138074 E049 8.0975960 0.0070540652 1.312651e-06 1.062725e-05 2 27208614 27208686 73 - 1.226 0.677 -2.078
ENSG00000138074 E050 359.3237289 0.0002049260 7.889321e-15 2.635528e-13 2 27211467 27211533 67 - 2.611 2.467 -0.480
ENSG00000138074 E051 19.9764889 0.0274351681 5.000770e-01 6.363471e-01 2 27211711 27211766 56 - 1.329 1.264 -0.228
ENSG00000138074 E052 43.5055212 0.0008072441 2.915028e-01 4.323758e-01 2 27211767 27211899 133 - 1.643 1.596 -0.162
ENSG00000138074 E053 78.4582546 0.0007518854 4.020931e-06 2.923166e-05 2 27211900 27212019 120 - 1.978 1.795 -0.616
ENSG00000138074 E054 110.8480882 0.0056908304 7.948110e-07 6.744057e-06 2 27212020 27212146 127 - 2.154 1.923 -0.774
ENSG00000138074 E055 59.8501165 0.0080487891 4.028457e-03 1.322209e-02 2 27212147 27212291 145 - 1.852 1.683 -0.571
ENSG00000138074 E056 0.1515154 0.0429733622 2.485216e-01   2 27212463 27212522 60 - 0.162 0.000 -9.118
ENSG00000138074 E057 3.7150350 0.0042491749 1.611966e-01 2.766618e-01 2 27212629 27212831 203 - 0.776 0.581 -0.825
ENSG00000138074 E058 3.5948399 0.0056388301 6.640147e-01 7.719321e-01 2 27212832 27212958 127 - 0.664 0.607 -0.248