ENSG00000138073

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000260643 ENSG00000138073 HEK293_OSMI2_2hA HEK293_TMG_2hB PREB protein_coding protein_coding 116.588 213.6697 63.11348 5.372475 1.814157 -1.759201 79.346343 143.14915 42.263104 9.4444885 0.7678830 -1.759808 0.68154583 0.66870000 0.67013333 0.001433333 1.0000000000 7.553618e-18 FALSE TRUE
ENST00000406567 ENSG00000138073 HEK293_OSMI2_2hA HEK293_TMG_2hB PREB protein_coding protein_coding 116.588 213.6697 63.11348 5.372475 1.814157 -1.759201 7.356187 13.26904 6.467909 0.7638790 0.3037115 -1.035551 0.06659583 0.06200000 0.10286667 0.040866667 0.0003766773 7.553618e-18 FALSE TRUE
ENST00000430533 ENSG00000138073 HEK293_OSMI2_2hA HEK293_TMG_2hB PREB protein_coding protein_coding 116.588 213.6697 63.11348 5.372475 1.814157 -1.759201 6.844949 10.72174 5.025523 0.7535293 0.5745862 -1.091671 0.06085000 0.05043333 0.07990000 0.029466667 0.1076759597 7.553618e-18 FALSE FALSE
ENST00000456259 ENSG00000138073 HEK293_OSMI2_2hA HEK293_TMG_2hB PREB protein_coding protein_coding 116.588 213.6697 63.11348 5.372475 1.814157 -1.759201 17.085748 40.02871 4.175664 5.6706887 0.6191453 -3.257867 0.12795000 0.18873333 0.06573333 -0.123000000 0.0004319438 7.553618e-18 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000138073 E001 45.619482 2.037079e-02 5.083473e-02 1.106635e-01 2 27130756 27130764 9 - 1.385 1.589 0.699
ENSG00000138073 E002 80.711257 1.756418e-02 8.802812e-01 9.272171e-01 2 27130765 27130774 10 - 1.788 1.805 0.055
ENSG00000138073 E003 173.649770 4.972104e-03 1.795954e-01 3.006327e-01 2 27130775 27130790 16 - 2.072 2.142 0.234
ENSG00000138073 E004 2148.613427 2.604538e-03 3.583808e-04 1.612535e-03 2 27130791 27131158 368 - 3.143 3.234 0.304
ENSG00000138073 E005 2235.460198 1.434196e-03 3.219437e-03 1.091293e-02 2 27131159 27131435 277 - 3.187 3.246 0.196
ENSG00000138073 E006 546.537110 1.719349e-04 4.132392e-01 5.567506e-01 2 27131436 27131439 4 - 2.610 2.627 0.055
ENSG00000138073 E007 960.847011 5.163703e-04 3.619560e-01 5.063541e-01 2 27131440 27131508 69 - 2.854 2.872 0.059
ENSG00000138073 E008 499.212285 8.267278e-04 3.962841e-01 5.400717e-01 2 27131672 27131673 2 - 2.566 2.588 0.075
ENSG00000138073 E009 1202.551200 1.001029e-04 9.923354e-04 3.932127e-03 2 27131674 27131831 158 - 2.928 2.973 0.148
ENSG00000138073 E010 21.681719 2.921786e-03 8.053135e-05 4.304374e-04 2 27131832 27132009 178 - 1.485 1.157 -1.146
ENSG00000138073 E011 904.495536 5.370642e-04 6.446435e-01 7.569092e-01 2 27132010 27132082 73 - 2.835 2.845 0.032
ENSG00000138073 E012 11.351265 8.616099e-03 6.906566e-03 2.098219e-02 2 27132204 27132229 26 - 1.206 0.900 -1.118
ENSG00000138073 E013 1298.981656 6.886157e-05 4.892643e-03 1.563142e-02 2 27132230 27132403 174 - 2.968 3.004 0.119
ENSG00000138073 E014 4.354379 3.689930e-03 1.662303e-02 4.410643e-02 2 27132511 27132602 92 - 0.898 0.548 -1.452
ENSG00000138073 E015 1301.537370 1.321162e-04 8.235329e-02 1.632240e-01 2 27132603 27132727 125 - 2.979 3.002 0.077
ENSG00000138073 E016 1048.906510 2.086146e-04 3.470289e-01 4.911992e-01 2 27132843 27132923 81 - 2.916 2.903 -0.045
ENSG00000138073 E017 600.682964 1.372336e-04 9.344211e-02 1.804997e-01 2 27133117 27133123 7 - 2.687 2.657 -0.102
ENSG00000138073 E018 1473.008850 1.025662e-03 9.380039e-03 2.723277e-02 2 27133124 27133337 214 - 3.090 3.045 -0.148
ENSG00000138073 E019 60.306400 7.470290e-03 1.358410e-05 8.749124e-05 2 27133338 27133531 194 - 1.883 1.603 -0.948
ENSG00000138073 E020 937.346501 1.699835e-03 6.126076e-04 2.579324e-03 2 27133532 27133654 123 - 2.920 2.842 -0.260
ENSG00000138073 E021 554.396782 1.005742e-03 9.080528e-04 3.641890e-03 2 27133655 27133721 67 - 2.690 2.613 -0.254
ENSG00000138073 E022 22.760191 1.254090e-03 1.517122e-09 2.174909e-08 2 27133722 27133798 77 - 1.602 1.145 -1.587
ENSG00000138073 E023 41.540789 5.409228e-04 3.027726e-28 4.368572e-26 2 27133799 27134286 488 - 1.937 1.327 -2.080
ENSG00000138073 E024 528.479633 3.174240e-03 2.167219e-02 5.499533e-02 2 27134287 27134361 75 - 2.666 2.595 -0.235
ENSG00000138073 E025 555.356357 1.272694e-02 3.679863e-02 8.508337e-02 2 27134362 27134541 180 - 2.719 2.610 -0.365
ENSG00000138073 E026 297.974907 1.591492e-02 5.630819e-03 1.763297e-02 2 27134542 27134803 262 - 2.496 2.325 -0.572