ENSG00000138036

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000260605 ENSG00000138036 HEK293_OSMI2_2hA HEK293_TMG_2hB DYNC2LI1 protein_coding protein_coding 17.38659 8.303068 29.92866 0.6138704 1.175919 1.848557 7.5316002 4.4054312 13.4418551 0.3326080 1.6408439 1.60717891 0.44330417 0.53356667 0.44960000 -0.08396667 0.59964785 0.02254444 FALSE TRUE
ENST00000378587 ENSG00000138036 HEK293_OSMI2_2hA HEK293_TMG_2hB DYNC2LI1 protein_coding protein_coding 17.38659 8.303068 29.92866 0.6138704 1.175919 1.848557 0.6275368 0.5937724 0.5823387 0.1208306 0.2022666 -0.02758253 0.04347917 0.07193333 0.01920000 -0.05273333 0.03416836 0.02254444 FALSE TRUE
ENST00000479242 ENSG00000138036 HEK293_OSMI2_2hA HEK293_TMG_2hB DYNC2LI1 protein_coding nonsense_mediated_decay 17.38659 8.303068 29.92866 0.6138704 1.175919 1.848557 1.8626480 0.1278591 5.2872950 0.1278591 1.0326580 5.26398982 0.07644167 0.01396667 0.17596667 0.16200000 0.02254444 0.02254444   FALSE
ENST00000605786 ENSG00000138036 HEK293_OSMI2_2hA HEK293_TMG_2hB DYNC2LI1 protein_coding protein_coding 17.38659 8.303068 29.92866 0.6138704 1.175919 1.848557 4.4402959 2.1511517 6.3383152 0.5725030 1.3199023 1.55457339 0.26692917 0.26283333 0.21140000 -0.05143333 0.84064872 0.02254444 FALSE TRUE
MSTRG.18297.2 ENSG00000138036 HEK293_OSMI2_2hA HEK293_TMG_2hB DYNC2LI1 protein_coding   17.38659 8.303068 29.92866 0.6138704 1.175919 1.848557 1.5544855 0.1583072 2.3980274 0.1583072 0.6718206 3.83868314 0.07320000 0.01726667 0.08073333 0.06346667 0.15506046 0.02254444 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000138036 E001 2.2142708 0.0086210314 0.8129475424 0.881379397 2 43774039 43774048 10 + 0.464 0.507 0.215
ENSG00000138036 E002 10.6361981 0.0016498292 0.0457905215 0.101651964 2 43774049 43774063 15 + 1.089 0.851 -0.887
ENSG00000138036 E003 30.1050673 0.0009302870 0.0476769761 0.105040937 2 43774064 43774081 18 + 1.489 1.344 -0.501
ENSG00000138036 E004 34.9974948 0.0005737785 0.0609194721 0.128182185 2 43774082 43774085 4 + 1.549 1.423 -0.432
ENSG00000138036 E005 84.6864286 0.0003701233 0.2430776911 0.377808639 2 43774086 43774145 60 + 1.906 1.857 -0.164
ENSG00000138036 E006 71.9222511 0.0008946136 0.4923112303 0.629492621 2 43774146 43774146 1 + 1.832 1.800 -0.107
ENSG00000138036 E007 0.3686942 0.0313922730 0.4366189667 0.578669236 2 43775709 43775788 80 + 0.076 0.192 1.539
ENSG00000138036 E008 80.6023442 0.0005596112 0.1300935690 0.234296055 2 43776782 43776822 41 + 1.889 1.822 -0.224
ENSG00000138036 E009 101.6980300 0.0003105325 0.0276181206 0.067252408 2 43776823 43776899 77 + 1.993 1.908 -0.288
ENSG00000138036 E010 0.4470576 0.0217053766 0.7610273966 0.844977918 2 43781628 43781764 137 + 0.141 0.191 0.534
ENSG00000138036 E011 64.2280554 0.0003896510 0.7445043391 0.832831115 2 43783520 43783554 35 + 1.778 1.764 -0.049
ENSG00000138036 E012 84.4294729 0.0003632209 0.7237353106 0.817485471 2 43787181 43787250 70 + 1.896 1.883 -0.045
ENSG00000138036 E013 110.0356419 0.0002887652 0.0722164635 0.147030547 2 43789633 43789721 89 + 2.024 1.958 -0.222
ENSG00000138036 E014 4.1899458 0.1015667468 0.8068817386 0.877329796 2 43792676 43794456 1781 + 0.667 0.694 0.115
ENSG00000138036 E015 162.9309277 0.0003155079 0.1733599809 0.292562920 2 43794457 43794643 187 + 2.188 2.148 -0.133
ENSG00000138036 E016 3.9209408 0.0063555656 0.0544011027 0.116958234 2 43794644 43795183 540 + 0.565 0.850 1.186
ENSG00000138036 E017 26.3407072 0.0073980945 0.5852618633 0.708981495 2 43795887 43795889 3 + 1.415 1.373 -0.145
ENSG00000138036 E018 92.5630273 0.0003546013 0.3432116965 0.487270690 2 43795890 43795958 69 + 1.922 1.961 0.130
ENSG00000138036 E019 0.3666179 0.0292419659 0.4350296808 0.577265689 2 43795959 43795959 1 + 0.076 0.192 1.539
ENSG00000138036 E020 83.9013627 0.0024853874 0.2189823820 0.349163864 2 43796718 43796795 78 + 1.875 1.932 0.194
ENSG00000138036 E021 89.0234688 0.0004582058 0.5895154590 0.712584447 2 43800841 43800917 77 + 1.910 1.933 0.079
ENSG00000138036 E022 5.6151752 0.1068059037 0.2217571935 0.352490561 2 43801271 43801638 368 + 0.683 0.949 1.048
ENSG00000138036 E023 88.5287557 0.0002995668 0.0615909822 0.129307890 2 43801639 43801709 71 + 1.890 1.966 0.255
ENSG00000138036 E024 98.4269671 0.0003494823 0.1250224452 0.227160601 2 43804642 43804739 98 + 1.939 1.998 0.201
ENSG00000138036 E025 97.6536091 0.0002991808 0.0792069410 0.158245986 2 43805154 43805246 93 + 1.933 2.001 0.229
ENSG00000138036 E026 7.1595690 0.0433226371 0.0141454327 0.038556750 2 43805247 43805555 309 + 0.731 1.087 1.356
ENSG00000138036 E027 78.5300379 0.0003917887 0.0006572442 0.002742006 2 43809705 43810010 306 + 1.814 1.958 0.483
ENSG00000138036 E028 2.4925381 0.0525056963 0.2435781515 0.378381603 2 43810381 43810524 144 + 0.566 0.325 -1.267
ENSG00000138036 E029 1.8907428 0.0084777425 0.4604287568 0.600471188 2 43827386 43827444 59 + 0.464 0.324 -0.785