ENSG00000138031

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000405392 ENSG00000138031 HEK293_OSMI2_2hA HEK293_TMG_2hB ADCY3 protein_coding protein_coding 38.05882 47.15048 33.67967 3.185985 0.8757421 -0.4852719 11.349073 14.689007 9.301056 1.4184438 0.39465485 -0.6587020 0.30368750 0.3109333 0.27596667 -0.03496667 0.5193525100 0.0003329859 FALSE TRUE
ENST00000485887 ENSG00000138031 HEK293_OSMI2_2hA HEK293_TMG_2hB ADCY3 protein_coding retained_intron 38.05882 47.15048 33.67967 3.185985 0.8757421 -0.4852719 4.013513 4.994016 2.754124 0.7254878 0.87674765 -0.8562640 0.10264583 0.1049000 0.08313333 -0.02176667 0.6889920901 0.0003329859 FALSE TRUE
ENST00000498288 ENSG00000138031 HEK293_OSMI2_2hA HEK293_TMG_2hB ADCY3 protein_coding protein_coding 38.05882 47.15048 33.67967 3.185985 0.8757421 -0.4852719 5.828508 11.761130 3.334837 1.6127062 0.59109443 -1.8152451 0.14319167 0.2491667 0.09843333 -0.15073333 0.0019840985 0.0003329859 FALSE FALSE
ENST00000606682 ENSG00000138031 HEK293_OSMI2_2hA HEK293_TMG_2hB ADCY3 protein_coding protein_coding 38.05882 47.15048 33.67967 3.185985 0.8757421 -0.4852719 4.750355 7.994792 2.031352 0.9765470 0.41920387 -1.9713388 0.11808750 0.1701667 0.06070000 -0.10946667 0.0046736830 0.0003329859 FALSE TRUE
ENST00000679454 ENSG00000138031 HEK293_OSMI2_2hA HEK293_TMG_2hB ADCY3 protein_coding protein_coding 38.05882 47.15048 33.67967 3.185985 0.8757421 -0.4852719 8.244070 6.488108 11.693501 1.2934915 0.09874752 0.8488486 0.22415833 0.1387333 0.34780000 0.20906667 0.0003329859 0.0003329859 FALSE TRUE
MSTRG.18070.12 ENSG00000138031 HEK293_OSMI2_2hA HEK293_TMG_2hB ADCY3 protein_coding   38.05882 47.15048 33.67967 3.185985 0.8757421 -0.4852719 1.175651 0.000000 2.323872 0.0000000 1.18855041 7.8665819 0.03703333 0.0000000 0.06756667 0.06756667 0.1523538193 0.0003329859 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000138031 E001 3.2333291 0.0055330050 1.476956e-03 5.562501e-03 2 24819169 24819171 3 - 0.235 0.780 2.811
ENSG00000138031 E002 9.8926539 0.0019111149 2.789782e-04 1.294208e-03 2 24819172 24819187 16 - 0.724 1.156 1.632
ENSG00000138031 E003 146.8359843 0.0063154947 1.481160e-13 4.109567e-12 2 24819188 24819368 181 - 1.888 2.283 1.324
ENSG00000138031 E004 925.8686203 0.0038289080 1.634967e-10 2.782426e-09 2 24819369 24820114 746 - 2.822 3.032 0.701
ENSG00000138031 E005 19.9095997 0.0309685936 6.737716e-01 7.793721e-01 2 24820246 24820383 138 - 1.332 1.291 -0.143
ENSG00000138031 E006 42.3798899 0.0036280735 7.792505e-01 8.580352e-01 2 24820384 24820451 68 - 1.602 1.635 0.112
ENSG00000138031 E007 58.3290638 0.0019060362 2.885443e-01 4.291468e-01 2 24820452 24820723 272 - 1.779 1.741 -0.128
ENSG00000138031 E008 334.0696494 0.0002074528 2.316100e-04 1.098373e-03 2 24820724 24820848 125 - 2.457 2.548 0.303
ENSG00000138031 E009 10.9899651 0.0016317803 2.549639e-01 3.917396e-01 2 24820849 24821516 668 - 1.120 1.020 -0.362
ENSG00000138031 E010 347.2471045 0.0047304718 1.582158e-01 2.727419e-01 2 24821517 24821640 124 - 2.487 2.561 0.249
ENSG00000138031 E011 3.1408774 0.0051142367 2.460267e-01 3.812880e-01 2 24821641 24822510 870 - 0.694 0.527 -0.734
ENSG00000138031 E012 331.6155269 0.0028301699 2.407392e-01 3.750386e-01 2 24822511 24822630 120 - 2.478 2.535 0.187
ENSG00000138031 E013 353.5411479 0.0011651717 6.337750e-01 7.483899e-01 2 24823209 24823355 147 - 2.523 2.552 0.096
ENSG00000138031 E014 1.0695761 0.0124895572 5.847694e-01 7.086109e-01 2 24823356 24823363 8 - 0.235 0.339 0.726
ENSG00000138031 E015 361.9104058 0.0001426794 7.224228e-02 1.470654e-01 2 24824378 24824536 159 - 2.559 2.540 -0.063
ENSG00000138031 E016 5.4855460 0.0584659914 6.532908e-02 1.355857e-01 2 24824770 24826044 1275 - 0.947 0.661 -1.136
ENSG00000138031 E017 233.0399660 0.0002087641 5.322019e-01 6.645666e-01 2 24826045 24826126 82 - 2.358 2.358 0.000
ENSG00000138031 E018 10.2600430 0.0201005108 1.179422e-01 2.169848e-01 2 24826127 24826129 3 - 0.893 1.103 0.780
ENSG00000138031 E019 0.4460135 0.0254287613 5.542255e-02 1.187136e-01 2 24826130 24826148 19 - 0.317 0.000 -11.972
ENSG00000138031 E020 137.8452781 0.0002961309 7.553411e-01 8.407091e-01 2 24827546 24827562 17 - 2.117 2.142 0.082
ENSG00000138031 E021 183.2664483 0.0002419478 6.614597e-01 7.699115e-01 2 24827563 24827608 46 - 2.254 2.257 0.011
ENSG00000138031 E022 248.9252051 0.0002812513 4.724398e-01 6.114923e-01 2 24827902 24828023 122 - 2.369 2.401 0.107
ENSG00000138031 E023 240.3660935 0.0001764274 4.948803e-01 6.317883e-01 2 24828024 24828161 138 - 2.351 2.382 0.104
ENSG00000138031 E024 5.9513397 0.0201131139 6.277081e-01 7.434615e-01 2 24828162 24828309 148 - 0.872 0.819 -0.204
ENSG00000138031 E025 39.2514442 0.0078971672 1.219738e-02 3.400523e-02 2 24828372 24830433 2062 - 1.687 1.528 -0.540
ENSG00000138031 E026 12.6764672 0.0257145350 3.845519e-02 8.820307e-02 2 24830434 24830708 275 - 1.251 1.020 -0.829
ENSG00000138031 E027 213.6876270 0.0004596240 5.622787e-01 6.899272e-01 2 24830709 24830825 117 - 2.319 2.320 0.000
ENSG00000138031 E028 191.3361906 0.0010343689 9.184476e-01 9.524644e-01 2 24831662 24831749 88 - 2.266 2.278 0.041
ENSG00000138031 E029 1.4382729 0.0094535372 4.374208e-02 9.791692e-02 2 24832126 24832185 60 - 0.545 0.202 -2.081
ENSG00000138031 E030 231.5038965 0.0003191317 5.075335e-01 6.430152e-01 2 24834485 24834646 162 - 2.354 2.353 -0.004
ENSG00000138031 E031 226.1464888 0.0025437843 4.727348e-01 6.117839e-01 2 24834794 24834925 132 - 2.347 2.341 -0.019
ENSG00000138031 E032 122.3159681 0.0013578868 2.227590e-01 3.536675e-01 2 24834926 24834936 11 - 2.094 2.065 -0.096
ENSG00000138031 E033 133.7617024 0.0002912912 7.840285e-02 1.569208e-01 2 24836917 24836952 36 - 2.140 2.100 -0.134
ENSG00000138031 E034 120.7291993 0.0016792964 4.268356e-02 9.596748e-02 2 24836953 24836981 29 - 2.108 2.047 -0.202
ENSG00000138031 E035 159.0711778 0.0002464834 3.187098e-03 1.081744e-02 2 24836982 24837045 64 - 2.231 2.162 -0.232
ENSG00000138031 E036 228.8544944 0.0009244391 2.802361e-02 6.805872e-02 2 24838445 24838622 178 - 2.375 2.331 -0.146
ENSG00000138031 E037 2.0617363 0.0069944420 2.214394e-01 3.521302e-01 2 24838847 24838912 66 - 0.587 0.394 -0.953
ENSG00000138031 E038 188.7413700 0.0003740800 8.711374e-03 2.556492e-02 2 24839873 24840006 134 - 2.296 2.241 -0.186
ENSG00000138031 E039 114.9470554 0.0003029959 1.779144e-01 2.985203e-01 2 24840007 24840031 25 - 2.068 2.038 -0.102
ENSG00000138031 E040 0.1817044 0.0397358323 5.952817e-01   2 24840525 24840603 79 - 0.000 0.113 9.562
ENSG00000138031 E041 140.4781184 0.0020672422 1.678599e-01 2.854090e-01 2 24841259 24841324 66 - 2.157 2.123 -0.113
ENSG00000138031 E042 141.6445418 0.0029453694 2.396738e-01 3.737293e-01 2 24841325 24841386 62 - 2.158 2.130 -0.094
ENSG00000138031 E043 178.6376671 0.0016625718 2.217622e-02 5.603844e-02 2 24841556 24841667 112 - 2.275 2.217 -0.193
ENSG00000138031 E044 181.2760081 0.0002170899 1.043241e-02 2.982192e-02 2 24842254 24842354 101 - 2.280 2.226 -0.179
ENSG00000138031 E045 110.7216999 0.0002684228 2.071229e-03 7.444846e-03 2 24842355 24842384 30 - 2.088 1.998 -0.301
ENSG00000138031 E046 1.9542136 0.0092809021 9.467660e-01 9.705787e-01 2 24842385 24842592 208 - 0.446 0.444 -0.009
ENSG00000138031 E047 190.9767676 0.0002698064 4.339140e-03 1.409359e-02 2 24872570 24872719 150 - 2.305 2.245 -0.201
ENSG00000138031 E048 0.0000000       2 24877922 24878027 106 -      
ENSG00000138031 E049 0.6244956 0.0434312624 8.290112e-01 8.926091e-01 2 24887645 24887669 25 - 0.234 0.202 -0.278
ENSG00000138031 E050 250.8109850 0.0037886639 1.188632e-02 3.325990e-02 2 24918313 24918651 339 - 2.433 2.359 -0.246
ENSG00000138031 E051 310.1594321 0.0072944391 3.689205e-04 1.653870e-03 2 24918652 24919184 533 - 2.561 2.422 -0.465
ENSG00000138031 E052 0.0000000       2 24919185 24919473 289 -      
ENSG00000138031 E053 0.3634088 0.3826227771 3.677836e-01   2 24919474 24919682 209 - 0.000 0.203 10.572
ENSG00000138031 E054 72.3339666 0.0122770970 2.567579e-11 5.003808e-10 2 24919683 24920237 555 - 2.061 1.623 -1.479