ENSG00000138018

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000260585 ENSG00000138018 HEK293_OSMI2_2hA HEK293_TMG_2hB SELENOI protein_coding protein_coding 17.97319 4.097876 26.43073 0.8075236 1.048848 2.686297 14.5491738 3.65240253 20.934095 0.80563564 0.4153861 2.5156812 0.85082917 0.88656667 0.793366667 -0.09320000 2.097052e-01 2.793645e-05 FALSE TRUE
ENST00000462301 ENSG00000138018 HEK293_OSMI2_2hA HEK293_TMG_2hB SELENOI protein_coding processed_transcript 17.97319 4.097876 26.43073 0.8075236 1.048848 2.686297 0.2147882 0.36816362 0.267513 0.12562400 0.1066875 -0.4464551 0.03573750 0.09363333 0.009866667 -0.08376667 8.614309e-04 2.793645e-05   FALSE
MSTRG.18088.2 ENSG00000138018 HEK293_OSMI2_2hA HEK293_TMG_2hB SELENOI protein_coding   17.97319 4.097876 26.43073 0.8075236 1.048848 2.686297 1.2328496 0.07730987 2.393878 0.01701128 0.4256830 4.7830754 0.04958333 0.01973333 0.089733333 0.07000000 9.982549e-04 2.793645e-05 TRUE TRUE
MSTRG.18088.3 ENSG00000138018 HEK293_OSMI2_2hA HEK293_TMG_2hB SELENOI protein_coding   17.97319 4.097876 26.43073 0.8075236 1.048848 2.686297 0.9585677 0.00000000 1.924861 0.00000000 0.5219546 7.5960860 0.03180417 0.00000000 0.071666667 0.07166667 2.793645e-05 2.793645e-05 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000138018 E001 0.000000       2 26308547 26308657 111 +      
ENSG00000138018 E002 2.110013 0.0069293698 9.087366e-01 9.460291e-01 2 26346065 26346125 61 + 0.378 0.452 0.403
ENSG00000138018 E003 5.978708 0.0027260680 3.212714e-01 4.645056e-01 2 26346126 26346142 17 + 0.713 0.669 -0.182
ENSG00000138018 E004 9.516272 0.0057813466 3.097687e-01 4.521132e-01 2 26346143 26346148 6 + 0.880 0.870 -0.039
ENSG00000138018 E005 25.047850 0.0007801005 1.452935e-02 3.943188e-02 2 26346149 26346177 29 + 1.269 1.169 -0.353
ENSG00000138018 E006 59.479299 0.0004121047 4.025574e-04 1.784354e-03 2 26346178 26346289 112 + 1.628 1.543 -0.290
ENSG00000138018 E007 2.876467 0.0070931455 5.778418e-06 4.055210e-05 2 26346589 26346900 312 + 0.229 1.045 3.863
ENSG00000138018 E008 66.275524 0.0003805076 6.769491e-05 3.690107e-04 2 26364302 26364370 69 + 1.678 1.576 -0.349
ENSG00000138018 E009 90.688911 0.0003363161 1.280891e-06 1.039634e-05 2 26364832 26364940 109 + 1.811 1.695 -0.393
ENSG00000138018 E010 81.435676 0.0003604486 7.530517e-09 9.493172e-08 2 26367146 26367220 75 + 1.772 1.565 -0.701
ENSG00000138018 E011 143.578262 0.0002418930 8.936566e-20 5.525475e-18 2 26373367 26373629 263 + 2.022 1.726 -0.996
ENSG00000138018 E012 64.533493 0.0016960964 5.039155e-08 5.430953e-07 2 26375040 26375089 50 + 1.678 1.426 -0.863
ENSG00000138018 E013 62.378468 0.0046900298 1.926756e-03 6.998988e-03 2 26375090 26375148 59 + 1.648 1.565 -0.282
ENSG00000138018 E014 63.202552 0.0045958021 2.054941e-03 7.396123e-03 2 26383299 26383347 49 + 1.653 1.575 -0.265
ENSG00000138018 E015 82.402329 0.0003279640 1.793166e-07 1.735073e-06 2 26384959 26385050 92 + 1.775 1.616 -0.538
ENSG00000138018 E016 87.772556 0.0015678315 1.810023e-07 1.749240e-06 2 26385051 26385139 89 + 1.802 1.635 -0.568
ENSG00000138018 E017 124.670666 0.0036296346 6.652870e-06 4.605087e-05 2 26386354 26386536 183 + 1.945 1.842 -0.348
ENSG00000138018 E018 374.214141 0.0005747340 7.048059e-16 2.717756e-14 2 26389005 26390050 1046 + 2.416 2.344 -0.242
ENSG00000138018 E019 1789.546425 0.0024652092 2.212604e-41 8.337102e-39 2 26390051 26395885 5835 + 3.033 3.330 0.990