ENSG00000137996

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000370128 ENSG00000137996 HEK293_OSMI2_2hA HEK293_TMG_2hB RTCA protein_coding protein_coding 25.44116 17.33131 35.88225 1.457503 1.124166 1.04946 17.868999 15.1156491 24.924846 1.4095760 1.0673855 0.7211662 0.7342542 0.8741667 0.6956000 -0.1785667 0.05798127 0.007101415 FALSE TRUE
ENST00000498617 ENSG00000137996 HEK293_OSMI2_2hA HEK293_TMG_2hB RTCA protein_coding processed_transcript 25.44116 17.33131 35.88225 1.457503 1.124166 1.04946 4.522955 0.8667889 6.856169 0.4456261 0.6961089 2.9692039 0.1493250 0.0487000 0.1905667 0.1418667 0.01017574 0.007101415 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000137996 E001 0.9641468 0.0122865458 2.645547e-01 4.025113e-01 1 100266179 100266180 2 + 0.350 0.155 -1.536
ENSG00000137996 E002 9.9634117 0.0035996984 3.490311e-03 1.169737e-02 1 100266181 100266215 35 + 1.135 0.817 -1.187
ENSG00000137996 E003 51.6962404 0.0004691820 1.430460e-04 7.166940e-04 1 100266216 100266245 30 + 1.778 1.601 -0.602
ENSG00000137996 E004 51.8392230 0.0005141798 1.271500e-04 6.463329e-04 1 100266246 100266248 3 + 1.780 1.601 -0.608
ENSG00000137996 E005 122.7454742 0.0041242530 3.995229e-03 1.313055e-02 1 100266249 100266288 40 + 2.128 2.014 -0.382
ENSG00000137996 E006 166.4908966 0.0043637598 2.252574e-02 5.677422e-02 1 100266289 100266362 74 + 2.248 2.167 -0.271
ENSG00000137996 E007 147.2147760 0.0018165521 6.722253e-03 2.050049e-02 1 100266363 100266420 58 + 2.197 2.117 -0.266
ENSG00000137996 E008 209.0529948 0.0011688399 1.836620e-05 1.149044e-04 1 100266524 100266624 101 + 2.358 2.249 -0.363
ENSG00000137996 E009 2.0135645 0.2653149205 4.225788e-01 5.657156e-01 1 100266625 100266929 305 + 0.540 0.360 -0.937
ENSG00000137996 E010 1.2555363 0.0100351434 4.480173e-01 5.893520e-01 1 100267166 100267245 80 + 0.396 0.268 -0.800
ENSG00000137996 E011 7.4127094 0.0023434487 8.002592e-02 1.595994e-01 1 100267500 100267538 39 + 0.986 0.787 -0.759
ENSG00000137996 E012 4.2511168 0.0042585244 1.990681e-01 3.250575e-01 1 100268074 100268136 63 + 0.775 0.601 -0.730
ENSG00000137996 E013 7.6955912 0.0021620115 3.024650e-01 4.443328e-01 1 100268137 100268151 15 + 0.975 0.870 -0.396
ENSG00000137996 E014 265.8643911 0.0003489082 5.120472e-08 5.508877e-07 1 100268152 100268295 144 + 2.462 2.354 -0.359
ENSG00000137996 E015 238.0153740 0.0001844611 3.512258e-02 8.187662e-02 1 100270557 100270680 124 + 2.384 2.354 -0.100
ENSG00000137996 E016 163.1368503 0.0008286121 1.897266e-01 3.134183e-01 1 100273394 100273452 59 + 2.219 2.198 -0.067
ENSG00000137996 E017 286.2092234 0.0009117282 4.456870e-01 5.872204e-01 1 100274824 100274965 142 + 2.436 2.473 0.124
ENSG00000137996 E018 276.0354722 0.0001699492 1.741108e-04 8.531351e-04 1 100275599 100275723 125 + 2.394 2.493 0.329
ENSG00000137996 E019 208.2454150 0.0002291484 3.700588e-02 8.548120e-02 1 100277258 100277316 59 + 2.284 2.355 0.236
ENSG00000137996 E020 244.0411511 0.0002316105 2.032689e-02 5.217131e-02 1 100285228 100285322 95 + 2.352 2.424 0.241
ENSG00000137996 E021 244.2114025 0.0001722748 1.318590e-02 3.634183e-02 1 100287099 100287203 105 + 2.352 2.428 0.251
ENSG00000137996 E022 539.8250832 0.0066655670 1.162189e-04 5.965624e-04 1 100291403 100292769 1367 + 2.652 2.817 0.549