ENSG00000137968

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000370855 ENSG00000137968 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC44A5 protein_coding protein_coding 4.622715 1.011625 8.437894 0.1587156 0.1265317 3.047726 1.2432582 0.139504639 2.6046427 0.008163883 0.06868338 4.128352 0.24891667 0.146100000 0.30856667 0.162466667 0.01400067 0.01167173 FALSE TRUE
ENST00000370859 ENSG00000137968 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC44A5 protein_coding protein_coding 4.622715 1.011625 8.437894 0.1587156 0.1265317 3.047726 2.2274521 0.690323199 3.9147725 0.100368689 0.09502878 2.486516 0.53846250 0.685600000 0.46446667 -0.221133333 0.01167173 0.01167173 FALSE TRUE
MSTRG.1425.3 ENSG00000137968 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC44A5 protein_coding   4.622715 1.011625 8.437894 0.1587156 0.1265317 3.047726 0.2731488 0.044237492 0.4135917 0.027073062 0.06688367 2.965312 0.05297083 0.042700000 0.04886667 0.006166667 0.89241756 0.01167173 FALSE TRUE
MSTRG.1425.8 ENSG00000137968 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC44A5 protein_coding   4.622715 1.011625 8.437894 0.1587156 0.1265317 3.047726 0.2955459 0.009472995 0.5807924 0.009472995 0.03016892 4.923104 0.04464167 0.007466667 0.06876667 0.061300000 0.05833265 0.01167173 FALSE TRUE
MSTRG.1425.9 ENSG00000137968 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC44A5 protein_coding   4.622715 1.011625 8.437894 0.1587156 0.1265317 3.047726 0.2941441 0.114932771 0.4809117 0.037269920 0.11695862 1.974312 0.06752917 0.106766667 0.05660000 -0.050166667 0.47824851 0.01167173 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000137968 E001 105.6081056 0.0005821986 6.397957e-26 7.599208e-24 1 75202129 75203505 1377 - 1.765 2.194 1.443
ENSG00000137968 E002 21.7316332 0.0008922062 8.215297e-03 2.433034e-02 1 75203506 75203616 111 - 1.137 1.398 0.919
ENSG00000137968 E003 14.7219848 0.0015494421 2.950558e-02 7.097867e-02 1 75203617 75203618 2 - 0.983 1.238 0.922
ENSG00000137968 E004 22.7608453 0.0014682566 9.143737e-03 2.664227e-02 1 75203619 75203665 47 - 1.160 1.414 0.889
ENSG00000137968 E005 41.3793645 0.0043673890 2.021731e-02 5.194214e-02 1 75203666 75203833 168 - 1.418 1.606 0.646
ENSG00000137968 E006 42.0107422 0.0005325845 6.761226e-01 7.811820e-01 1 75204475 75205262 788 - 1.458 1.430 -0.097
ENSG00000137968 E007 75.5807387 0.0003666335 6.359688e-01 7.501082e-01 1 75205263 75206485 1223 - 1.704 1.681 -0.076
ENSG00000137968 E008 9.9934986 0.0072039674 2.035921e-01 3.307061e-01 1 75206486 75206537 52 - 0.901 0.684 -0.859
ENSG00000137968 E009 24.4720354 0.0008256661 4.810147e-02 1.058088e-01 1 75206538 75206719 182 - 1.255 1.025 -0.826
ENSG00000137968 E010 23.5444031 0.0008339972 5.323631e-01 6.647372e-01 1 75211468 75211552 85 - 1.222 1.159 -0.223
ENSG00000137968 E011 19.9275813 0.0009731153 7.922294e-01 8.671301e-01 1 75213705 75213793 89 - 1.154 1.129 -0.087
ENSG00000137968 E012 18.2617214 0.0009781293 2.410797e-01 3.754456e-01 1 75213919 75213989 71 - 1.129 0.984 -0.531
ENSG00000137968 E013 15.3825306 0.0014030096 3.674226e-01 5.118020e-01 1 75214605 75214678 74 - 1.056 0.938 -0.435
ENSG00000137968 E014 17.1943198 0.0010503630 1.920380e-01 3.163038e-01 1 75215754 75215857 104 - 1.108 0.938 -0.622
ENSG00000137968 E015 16.5157003 0.0011091858 5.659798e-02 1.207563e-01 1 75217866 75217960 95 - 1.100 0.830 -1.010
ENSG00000137968 E016 19.5134494 0.0010123267 1.262050e-03 4.850123e-03 1 75218490 75218595 106 - 1.177 0.685 -1.869
ENSG00000137968 E017 26.9543291 0.0033885212 3.541008e-03 1.184318e-02 1 75218596 75218752 157 - 1.303 0.938 -1.315
ENSG00000137968 E018 24.4112521 0.0007404742 3.732154e-03 1.238931e-02 1 75219257 75219344 88 - 1.261 0.887 -1.358
ENSG00000137968 E019 25.3872823 0.0007932102 6.835186e-04 2.838709e-03 1 75219800 75219892 93 - 1.281 0.830 -1.653
ENSG00000137968 E020 27.0036986 0.0007589292 9.506716e-04 3.790262e-03 1 75222361 75222460 100 - 1.306 0.887 -1.516
ENSG00000137968 E021 32.7782087 0.0036760580 3.942001e-02 8.995643e-02 1 75227726 75227857 132 - 1.373 1.159 -0.753
ENSG00000137968 E022 29.9500608 0.0006874909 4.852739e-02 1.065589e-01 1 75233986 75234098 113 - 1.335 1.129 -0.727
ENSG00000137968 E023 23.2973464 0.0008397755 3.797196e-01 5.239689e-01 1 75236987 75237070 84 - 1.222 1.129 -0.330
ENSG00000137968 E024 35.7933620 0.0005971367 2.309589e-02 5.794527e-02 1 75238513 75238636 124 - 1.409 1.187 -0.774
ENSG00000137968 E025 24.8557904 0.0017623805 4.432015e-02 9.896886e-02 1 75242001 75242061 61 - 1.261 1.025 -0.844
ENSG00000137968 E026 17.6671742 0.0010243754 1.637447e-01 2.800124e-01 1 75242886 75242919 34 - 1.119 0.938 -0.662
ENSG00000137968 E027 23.2551425 0.0025941885 6.471006e-03 1.984737e-02 1 75242920 75243011 92 - 1.244 0.887 -1.303
ENSG00000137968 E028 22.5458245 0.0051157005 2.697681e-02 6.594676e-02 1 75251210 75251294 85 - 1.225 0.938 -1.040
ENSG00000137968 E029 19.6904017 0.0009444869 8.612182e-01 9.144651e-01 1 75274958 75275042 85 - 1.143 1.129 -0.050
ENSG00000137968 E030 14.8089931 0.0208953199 7.796961e-01 8.583761e-01 1 75300612 75300685 74 - 1.020 1.065 0.163
ENSG00000137968 E031 0.0000000       1 75311615 75311705 91 -      
ENSG00000137968 E032 12.7704576 0.0065312444 7.808006e-02 1.563904e-01 1 75339582 75339630 49 - 0.930 1.160 0.843
ENSG00000137968 E033 5.1798909 0.0032265620 1.857528e-01 3.084406e-01 1 75375816 75376083 268 - 0.600 0.830 0.950
ENSG00000137968 E034 7.5369168 0.1186611312 2.638860e-02 6.472599e-02 1 75376084 75376168 85 - 0.668 1.146 1.827
ENSG00000137968 E035 7.8272673 0.0287280635 4.621390e-01 6.020261e-01 1 75376169 75376628 460 - 0.760 0.891 0.511
ENSG00000137968 E036 0.5891098 0.0184223543 1.000000e+00 1.000000e+00 1 75396583 75396621 39 - 0.159 0.000 -8.626
ENSG00000137968 E037 0.4439371 0.0216008722 1.000000e+00 1.000000e+00 1 75396622 75396622 1 - 0.124 0.000 -8.229
ENSG00000137968 E038 0.0000000       1 75398355 75398421 67 -      
ENSG00000137968 E039 0.4439371 0.0216008722 1.000000e+00 1.000000e+00 1 75541435 75541516 82 - 0.124 0.000 -8.229
ENSG00000137968 E040 0.0000000       1 75611040 75611114 75 -      
ENSG00000137968 E041 2.3659026 0.0062396877 5.616970e-01 6.894457e-01 1 75615853 75615985 133 - 0.424 0.292 -0.788