ENSG00000137941

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000260505 ENSG00000137941 HEK293_OSMI2_2hA HEK293_TMG_2hB TTLL7 protein_coding protein_coding 1.855769 0.5326959 3.651547 0.09372103 0.6122418 2.754238 0.44582293 0.11763029 0.92698072 0.06587208 0.114889554 2.876049 0.22700833 0.2385667 0.27420000 0.035633333 0.8655214572 0.0002742097 FALSE TRUE
ENST00000467670 ENSG00000137941 HEK293_OSMI2_2hA HEK293_TMG_2hB TTLL7 protein_coding processed_transcript 1.855769 0.5326959 3.651547 0.09372103 0.6122418 2.754238 0.13096335 0.03343940 0.23057676 0.01734142 0.140675790 2.469421 0.07080833 0.0724000 0.05320000 -0.019200000 0.8576225759 0.0002742097   FALSE
ENST00000472688 ENSG00000137941 HEK293_OSMI2_2hA HEK293_TMG_2hB TTLL7 protein_coding processed_transcript 1.855769 0.5326959 3.651547 0.09372103 0.6122418 2.754238 0.06339298 0.10764740 0.02270428 0.04209494 0.001873913 -1.846918 0.07563750 0.2326000 0.00640000 -0.226200000 0.0002742097 0.0002742097 FALSE TRUE
ENST00000474702 ENSG00000137941 HEK293_OSMI2_2hA HEK293_TMG_2hB TTLL7 protein_coding processed_transcript 1.855769 0.5326959 3.651547 0.09372103 0.6122418 2.754238 0.09669733 0.00000000 0.51552638 0.00000000 0.257804321 5.715691 0.02511250 0.0000000 0.12583333 0.125833333 0.5005871968 0.0002742097   FALSE
ENST00000482783 ENSG00000137941 HEK293_OSMI2_2hA HEK293_TMG_2hB TTLL7 protein_coding processed_transcript 1.855769 0.5326959 3.651547 0.09372103 0.6122418 2.754238 0.05060321 0.07285665 0.04587990 0.07285665 0.045879901 -0.568288 0.04615000 0.1133667 0.00970000 -0.103666667 0.6498058716 0.0002742097 FALSE FALSE
ENST00000485638 ENSG00000137941 HEK293_OSMI2_2hA HEK293_TMG_2hB TTLL7 protein_coding nonsense_mediated_decay 1.855769 0.5326959 3.651547 0.09372103 0.6122418 2.754238 0.17907228 0.05719512 0.37995484 0.05719512 0.164701786 2.536879 0.09893333 0.0890000 0.09716667 0.008166667 0.9009315974 0.0002742097 TRUE TRUE
MSTRG.1484.8 ENSG00000137941 HEK293_OSMI2_2hA HEK293_TMG_2hB TTLL7 protein_coding   1.855769 0.5326959 3.651547 0.09372103 0.6122418 2.754238 0.69718876 0.09339752 1.14437822 0.07307201 0.255397311 3.480843 0.35135833 0.1711000 0.34666667 0.175566667 0.5688836894 0.0002742097 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000137941 E001 0.1451727 0.043225365 1.000000000   1 83865024 83865027 4 - 0.054 0.000 -8.235
ENSG00000137941 E002 70.2583374 0.012913668 0.018190816 0.047542911 1 83865028 83869697 4670 - 1.699 1.858 0.538
ENSG00000137941 E003 2.4316797 0.008567534 0.804810854 0.875805897 1 83869698 83869748 51 - 0.458 0.413 -0.236
ENSG00000137941 E004 2.4702877 0.006308390 0.657514402 0.766859961 1 83869749 83869765 17 - 0.437 0.529 0.456
ENSG00000137941 E005 9.0692369 0.002282214 0.438243891 0.580141083 1 83869766 83869977 212 - 0.877 0.988 0.415
ENSG00000137941 E006 9.8516779 0.001844955 0.371722689 0.516193866 1 83869978 83870082 105 - 0.900 1.022 0.456
ENSG00000137941 E007 0.0000000       1 83879893 83879983 91 -      
ENSG00000137941 E008 0.0000000       1 83880261 83880294 34 -      
ENSG00000137941 E009 0.0000000       1 83882669 83882787 119 -      
ENSG00000137941 E010 0.0000000       1 83882788 83882801 14 -      
ENSG00000137941 E011 0.0000000       1 83882802 83882962 161 -      
ENSG00000137941 E012 7.4160348 0.002412692 0.701159522 0.800417057 1 83882963 83883012 50 - 0.802 0.866 0.250
ENSG00000137941 E013 8.6232089 0.002193284 0.175370191 0.295148196 1 83883013 83883136 124 - 0.837 1.022 0.697
ENSG00000137941 E014 0.1515154 0.042583606 1.000000000   1 83885076 83885094 19 - 0.054 0.000 -10.246
ENSG00000137941 E015 0.7490443 0.072385173 0.504018290 0.639931057 1 83887177 83887284 108 - 0.222 0.000 -12.241
ENSG00000137941 E016 10.9170021 0.001703013 0.142496206 0.251432248 1 83890321 83890481 161 - 0.928 1.111 0.671
ENSG00000137941 E017 0.1451727 0.043225365 1.000000000   1 83902009 83902153 145 - 0.054 0.000 -10.245
ENSG00000137941 E018 0.0000000       1 83902154 83902240 87 -      
ENSG00000137941 E019 10.4011330 0.001694845 0.290186007 0.430972628 1 83904079 83904159 81 - 0.914 1.054 0.517
ENSG00000137941 E020 12.3113302 0.015958957 0.359386808 0.503715848 1 83906329 83906463 135 - 0.985 1.111 0.458
ENSG00000137941 E021 0.4460135 0.032907692 1.000000000 1.000000000 1 83906464 83906523 60 - 0.146 0.000 -11.656
ENSG00000137941 E022 14.9520504 0.002644300 0.863217879 0.915797993 1 83907456 83907661 206 - 1.082 1.111 0.103
ENSG00000137941 E023 8.4294133 0.001951691 0.726722245 0.819657130 1 83911165 83911235 71 - 0.854 0.911 0.218
ENSG00000137941 E024 9.1912568 0.002214369 0.942715025 0.968034618 1 83911236 83911363 128 - 0.893 0.911 0.069
ENSG00000137941 E025 0.1472490 0.043663274 1.000000000   1 83912444 83912503 60 - 0.054 0.000 -10.245
ENSG00000137941 E026 0.4470576 0.021552292 0.388895738 0.532979243 1 83912933 83912995 63 - 0.103 0.253 1.569
ENSG00000137941 E027 0.1482932 0.041905995 0.064073449   1 83912996 83913040 45 - 0.000 0.253 13.129
ENSG00000137941 E028 10.2281794 0.001767329 0.304834464 0.446856795 1 83917604 83917685 82 - 0.955 0.817 -0.528
ENSG00000137941 E029 5.8973379 0.002966112 0.181716905 0.303392314 1 83917686 83917686 1 - 0.764 0.529 -1.013
ENSG00000137941 E030 6.5293221 0.002516731 0.290791890 0.431591636 1 83917687 83917690 4 - 0.793 0.621 -0.714
ENSG00000137941 E031 0.0000000       1 83917691 83917704 14 -      
ENSG00000137941 E032 12.4454858 0.004965188 0.330789617 0.474362648 1 83919699 83919834 136 - 1.031 0.911 -0.448
ENSG00000137941 E033 0.0000000       1 83920523 83920615 93 -      
ENSG00000137941 E034 9.8665440 0.006780455 0.362090620 0.506490015 1 83921087 83921160 74 - 0.942 0.817 -0.479
ENSG00000137941 E035 14.0478432 0.018178018 0.857225643 0.911825328 1 83921247 83921394 148 - 1.052 1.085 0.118
ENSG00000137941 E036 12.1471001 0.021573561 0.418019314 0.561334465 1 83929136 83929230 95 - 1.021 0.911 -0.409
ENSG00000137941 E037 15.8099183 0.015589293 0.266975421 0.405246772 1 83933608 83933766 159 - 1.128 0.988 -0.510
ENSG00000137941 E038 13.8194084 0.048466323 0.475108901 0.613866998 1 83937852 83938016 165 - 1.074 0.950 -0.454
ENSG00000137941 E039 13.7029621 0.019887563 0.260943322 0.398536239 1 83942463 83942679 217 - 1.068 0.914 -0.571
ENSG00000137941 E040 0.0000000       1 83946000 83946412 413 -      
ENSG00000137941 E041 10.3006661 0.002215732 0.158060398 0.272538264 1 83947124 83947282 159 - 0.961 0.761 -0.774
ENSG00000137941 E042 2.3744208 0.007087060 0.883922147 0.929770962 1 83947283 83947626 344 - 0.437 0.413 -0.128
ENSG00000137941 E043 6.8354629 0.002379944 0.022579510 0.056879468 1 83948628 83948695 68 - 0.837 0.413 -1.888
ENSG00000137941 E044 0.4418608 0.025501773 1.000000000 1.000000000 1 83948696 83948936 241 - 0.146 0.000 -11.659
ENSG00000137941 E045 2.4130434 0.006800297 0.802908933 0.874496414 1 83949313 83949864 552 - 0.458 0.413 -0.237
ENSG00000137941 E046 7.4026891 0.002490556 0.001943336 0.007050831 1 83949865 83949986 122 - 0.877 0.254 -3.044
ENSG00000137941 E047 8.3853956 0.002112278 0.380272138 0.524559410 1 83951845 83951976 132 - 0.885 0.760 -0.488
ENSG00000137941 E048 6.7310977 0.002616217 0.523246008 0.656968459 1 83952187 83952387 201 - 0.764 0.866 0.401
ENSG00000137941 E049 8.6880331 0.014306260 0.625124990 0.741315806 1 83998931 83999150 220 - 0.885 0.817 -0.262