ENSG00000137876

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000260443 ENSG00000137876 HEK293_OSMI2_2hA HEK293_TMG_2hB RSL24D1 protein_coding protein_coding 59.74611 20.62689 97.96361 3.481189 4.221899 2.247167 3.5060235 0.6930687 5.166807 0.4788484 0.7113349 2.880325 0.05027083 0.02950000 0.05233333 0.022833333 0.61513317 0.04157802 FALSE  
ENST00000677147 ENSG00000137876 HEK293_OSMI2_2hA HEK293_TMG_2hB RSL24D1 protein_coding protein_coding 59.74611 20.62689 97.96361 3.481189 4.221899 2.247167 0.3623937 1.2489212 0.000000 0.6648222 0.0000000 -6.976044 0.00935000 0.05886667 0.00000000 -0.058866667 0.04157802 0.04157802 FALSE  
ENST00000677730 ENSG00000137876 HEK293_OSMI2_2hA HEK293_TMG_2hB RSL24D1 protein_coding protein_coding 59.74611 20.62689 97.96361 3.481189 4.221899 2.247167 31.0062741 9.3969038 51.625409 1.5586896 1.0987970 2.456569 0.51424167 0.45713333 0.52806667 0.070933333 0.12400710 0.04157802 FALSE  
MSTRG.10840.9 ENSG00000137876 HEK293_OSMI2_2hA HEK293_TMG_2hB RSL24D1 protein_coding   59.74611 20.62689 97.96361 3.481189 4.221899 2.247167 24.0769063 8.5633300 40.619861 1.3872322 2.5029898 2.244613 0.39832500 0.41630000 0.41396667 -0.002333333 1.00000000 0.04157802 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000137876 E001 5.7154790 0.1847700093 3.052925e-01 4.473586e-01 15 55180806 55181141 336 - 0.680 0.967 1.128
ENSG00000137876 E002 2.2444863 0.1021097802 1.276514e-01 2.308810e-01 15 55181142 55181159 18 - 0.364 0.721 1.700
ENSG00000137876 E003 3.4009335 0.0159766053 6.281633e-02 1.314029e-01 15 55181160 55181207 48 - 0.483 0.832 1.505
ENSG00000137876 E004 8.8924560 0.0024675179 1.253886e-06 1.019988e-05 15 55181208 55181314 107 - 0.730 1.313 2.163
ENSG00000137876 E005 18.6110828 0.0009951540 2.173992e-10 3.616263e-09 15 55181315 55181336 22 - 1.020 1.588 1.994
ENSG00000137876 E006 17.8704576 0.0010594928 3.021425e-11 5.816482e-10 15 55181337 55181337 1 - 0.989 1.588 2.110
ENSG00000137876 E007 1045.6581403 0.0041268760 2.079020e-09 2.900752e-08 15 55181338 55182044 707 - 2.873 3.074 0.668
ENSG00000137876 E008 440.9116336 0.0002046070 2.627942e-02 6.450831e-02 15 55182045 55182219 175 - 2.526 2.623 0.325
ENSG00000137876 E009 199.2014159 0.0001878668 6.550018e-01 7.650095e-01 15 55182220 55182225 6 - 2.189 2.256 0.223
ENSG00000137876 E010 0.6017953 0.1702822375 5.507700e-01 6.803389e-01 15 55183311 55183314 4 - 0.200 0.000 -10.520
ENSG00000137876 E011 364.6064543 0.0002065662 1.867505e-01 3.096550e-01 15 55183315 55183400 86 - 2.460 2.482 0.075
ENSG00000137876 E012 3.3257949 0.0045908071 9.662218e-01 9.828012e-01 15 55183401 55185361 1961 - 0.559 0.592 0.147
ENSG00000137876 E013 368.2898547 0.0010765335 8.089077e-05 4.321878e-04 15 55185362 55185425 64 - 2.479 2.419 -0.200
ENSG00000137876 E014 1.3672092 0.0096765512 7.912459e-02 1.581160e-01 15 55185426 55186842 1417 - 0.238 0.591 1.993
ENSG00000137876 E015 335.1586072 0.0001775936 1.729133e-09 2.452122e-08 15 55190975 55191047 73 - 2.444 2.345 -0.333
ENSG00000137876 E016 0.2966881 0.0268982108 1.000000e+00   15 55192403 55192710 308 - 0.111 0.000 -10.219
ENSG00000137876 E017 0.8942170 0.0136871839 2.630830e-01 4.009417e-01 15 55192711 55192719 9 - 0.273 0.000 -11.876
ENSG00000137876 E018 176.2664882 0.0002117334 1.411679e-07 1.393706e-06 15 55192720 55192722 3 - 2.174 2.038 -0.453
ENSG00000137876 E019 409.1978791 0.0002135620 8.340953e-16 3.185181e-14 15 55192723 55192833 111 - 2.537 2.401 -0.454
ENSG00000137876 E020 0.0000000       15 55193170 55193231 62 -      
ENSG00000137876 E021 0.4439371 0.0215906797 7.323831e-01 8.238396e-01 15 55194153 55194183 31 - 0.158 0.000 -10.839
ENSG00000137876 E022 0.7352129 0.1274071757 1.000000e+00 1.000000e+00 15 55194296 55194359 64 - 0.199 0.236 0.308
ENSG00000137876 E023 0.1515154 0.0441911025 1.000000e+00   15 55194898 55195008 111 - 0.059 0.000 -9.092
ENSG00000137876 E024 0.5827671 0.1135465129 5.351313e-01 6.670682e-01 15 55195304 55195591 288 - 0.199 0.000 -10.699
ENSG00000137876 E025 1.3487633 0.1308423850 1.619255e-01 2.776336e-01 15 55196353 55196521 169 - 0.365 0.000 -11.799
ENSG00000137876 E026 0.7448917 0.0476492181 3.687820e-01 5.131988e-01 15 55196522 55196809 288 - 0.238 0.000 -11.375
ENSG00000137876 E027 297.3555759 0.0002106087 1.860387e-13 5.095340e-12 15 55196810 55196967 158 - 2.401 2.249 -0.507
ENSG00000137876 E028 1.5469139 0.0084958460 4.692283e-01 6.085003e-01 15 55196968 55197053 86 - 0.364 0.237 -0.852