ENSG00000137845

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000260408 ENSG00000137845 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAM10 protein_coding protein_coding 12.10245 2.448707 19.75027 0.1921891 0.9992008 3.00663 1.8845587 0.78103575 3.14256581 0.05288935 0.09153477 1.994712 0.22565417 0.32646667 0.159466667 -0.16700000 0.004498058 0.0007395998 FALSE TRUE
ENST00000396136 ENSG00000137845 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAM10 protein_coding nonsense_mediated_decay 12.10245 2.448707 19.75027 0.1921891 0.9992008 3.00663 3.2524259 0.42484026 4.81986164 0.25987016 0.08303183 3.473424 0.23698750 0.16013333 0.245233333 0.08510000 0.670461363 0.0007395998 FALSE TRUE
ENST00000402627 ENSG00000137845 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAM10 protein_coding protein_coding 12.10245 2.448707 19.75027 0.1921891 0.9992008 3.00663 1.1175978 0.08486612 2.37757449 0.08486612 0.50388664 4.653509 0.06667083 0.03176667 0.118333333 0.08656667 0.207396787 0.0007395998 TRUE FALSE
ENST00000558733 ENSG00000137845 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAM10 protein_coding processed_transcript 12.10245 2.448707 19.75027 0.1921891 0.9992008 3.00663 0.1929255 0.17893622 0.06742771 0.06733722 0.06742771 -1.286977 0.03387500 0.06933333 0.003166667 -0.06616667 0.022338087 0.0007395998 FALSE TRUE
MSTRG.10907.3 ENSG00000137845 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAM10 protein_coding   12.10245 2.448707 19.75027 0.1921891 0.9992008 3.00663 5.3190272 0.78105703 9.15418461 0.14814938 0.42459105 3.534153 0.39701250 0.32546667 0.463866667 0.13840000 0.258004171 0.0007395998 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000137845 E001 359.1849050 0.0020448974 1.005274e-21 7.745029e-20 15 58588809 58596871 8063 - 2.361 2.645 0.944
ENSG00000137845 E002 80.1644022 0.0009449038 9.831019e-01 9.934853e-01 15 58596872 58597163 292 - 1.768 1.795 0.090
ENSG00000137845 E003 18.1259287 0.0010512025 2.622943e-01 4.000746e-01 15 58597164 58597164 1 - 1.127 1.265 0.490
ENSG00000137845 E004 26.2471143 0.0007070795 2.905070e-01 4.313282e-01 15 58597165 58597201 37 - 1.282 1.399 0.406
ENSG00000137845 E005 94.9920350 0.0003665401 9.622020e-01 9.801656e-01 15 58597202 58597518 317 - 1.841 1.869 0.094
ENSG00000137845 E006 60.5003765 0.0003777930 6.631725e-01 7.713079e-01 15 58597519 58597641 123 - 1.654 1.653 -0.005
ENSG00000137845 E007 63.0270561 0.0004188456 2.934350e-01 4.344967e-01 15 58599598 58599724 127 - 1.653 1.740 0.294
ENSG00000137845 E008 0.4545463 0.6150525060 1.000000e+00 1.000000e+00 15 58609158 58610296 1139 - 0.142 0.000 -10.609
ENSG00000137845 E009 103.7447513 0.0020176465 8.962121e-03 2.618477e-02 15 58610297 58610517 221 - 1.855 2.006 0.509
ENSG00000137845 E010 0.0000000       15 58610518 58610926 409 -      
ENSG00000137845 E011 0.0000000       15 58610927 58610998 72 -      
ENSG00000137845 E012 85.3584176 0.0003624066 4.911769e-01 6.284757e-01 15 58610999 58611107 109 - 1.788 1.849 0.205
ENSG00000137845 E013 0.0000000       15 58611108 58611275 168 -      
ENSG00000137845 E014 0.2955422 0.0298004675 1.912488e-01   15 58611276 58611807 532 - 0.052 0.262 2.695
ENSG00000137845 E015 60.2572615 0.0004213243 1.281621e-01 2.316013e-01 15 58611808 58611853 46 - 1.631 1.746 0.389
ENSG00000137845 E016 90.6453953 0.0003245602 8.423869e-01 9.017912e-01 15 58611854 58611991 138 - 1.823 1.839 0.053
ENSG00000137845 E017 93.4819327 0.0004881025 2.073473e-01 3.353214e-01 15 58621471 58621621 151 - 1.845 1.806 -0.131
ENSG00000137845 E018 39.7029447 0.0009291702 1.551912e-02 4.167035e-02 15 58627700 58627711 12 - 1.499 1.320 -0.618
ENSG00000137845 E019 100.4391597 0.0002966233 1.097105e-03 4.294227e-03 15 58627712 58627883 172 - 1.890 1.746 -0.487
ENSG00000137845 E020 0.0000000       15 58629264 58629464 201 -      
ENSG00000137845 E021 68.4357139 0.0003714795 3.854334e-02 8.835497e-02 15 58633196 58633314 119 - 1.721 1.619 -0.346
ENSG00000137845 E022 35.5924491 0.0011081503 1.156486e-01 2.137616e-01 15 58633315 58633359 45 - 1.446 1.337 -0.379
ENSG00000137845 E023 59.6697047 0.0005266221 6.041630e-02 1.273257e-01 15 58640777 58640830 54 - 1.662 1.564 -0.335
ENSG00000137845 E024 74.9529251 0.0009311146 2.042816e-01 3.315162e-01 15 58640831 58640960 130 - 1.754 1.705 -0.164
ENSG00000137845 E025 51.5155382 0.0004452508 1.489494e-03 5.602413e-03 15 58643886 58643978 93 - 1.613 1.399 -0.734
ENSG00000137845 E026 60.4311237 0.0004086689 6.165432e-04 2.594107e-03 15 58646055 58646204 150 - 1.679 1.465 -0.730
ENSG00000137845 E027 1.2835458 0.0140205356 2.622156e-05 1.581785e-04 15 58655243 58655416 174 - 0.052 0.777 5.285
ENSG00000137845 E028 34.5326113 0.0009243368 1.541592e-02 4.143553e-02 15 58665097 58665145 49 - 1.440 1.245 -0.680
ENSG00000137845 E029 22.0612291 0.0114889980 1.419898e-02 3.867545e-02 15 58665146 58665151 6 - 1.264 0.969 -1.063
ENSG00000137845 E030 33.8456589 0.0052854924 1.898927e-02 4.930971e-02 15 58665152 58665181 30 - 1.432 1.225 -0.723
ENSG00000137845 E031 35.4304042 0.0005868786 1.170449e-03 4.540557e-03 15 58665182 58665197 16 - 1.458 1.179 -0.976
ENSG00000137845 E032 0.1515154 0.0427038049 9.331301e-01   15 58676143 58676293 151 - 0.052 0.000 -8.769
ENSG00000137845 E033 41.7519090 0.0004963131 3.407307e-03 1.145913e-02 15 58679124 58679158 35 - 1.523 1.303 -0.761
ENSG00000137845 E034 59.1361643 0.0023260687 5.591830e-03 1.753261e-02 15 58679159 58679282 124 - 1.666 1.489 -0.604
ENSG00000137845 E035 37.8283882 0.0073599857 4.210176e-03 1.373145e-02 15 58682196 58682251 56 - 1.486 1.224 -0.912
ENSG00000137845 E036 39.8791742 0.0005378029 1.397324e-02 3.816317e-02 15 58682252 58682314 63 - 1.501 1.320 -0.624
ENSG00000137845 E037 0.2965864 0.1865157035 1.457609e-02   15 58698280 58698404 125 - 0.000 0.419 13.671
ENSG00000137845 E038 0.0000000       15 58707307 58707380 74 -      
ENSG00000137845 E039 48.6175518 0.0004450961 3.614760e-05 2.105597e-04 15 58717577 58717727 151 - 1.598 1.284 -1.081
ENSG00000137845 E040 4.9078725 0.0604652890 1.896565e-05 1.182720e-04 15 58747345 58748794 1450 - 0.425 1.158 3.011
ENSG00000137845 E041 1.8047865 0.0094982596 3.607232e-06 2.652767e-05 15 58748795 58749036 242 - 0.099 0.883 4.700
ENSG00000137845 E042 52.3755288 0.0019748708 1.040602e-01 1.966904e-01 15 58749480 58749791 312 - 1.604 1.512 -0.315