ENSG00000137824

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000338376 ENSG00000137824 HEK293_OSMI2_2hA HEK293_TMG_2hB RMDN3 protein_coding protein_coding 26.55128 22.60053 29.00307 0.5137205 0.9980362 0.3597083 15.980843 15.281592 16.0164549 1.0431069 0.4709279 0.06771675 0.61660000 0.67496667 0.55443333 -0.12053333 1.580346e-01 3.273606e-25 FALSE TRUE
ENST00000558364 ENSG00000137824 HEK293_OSMI2_2hA HEK293_TMG_2hB RMDN3 protein_coding processed_transcript 26.55128 22.60053 29.00307 0.5137205 0.9980362 0.3597083 1.971788 1.353180 1.8914157 0.7805379 0.1123154 0.48009801 0.07124167 0.06083333 0.06523333 0.00440000 7.983815e-01 3.273606e-25 FALSE FALSE
ENST00000558560 ENSG00000137824 HEK293_OSMI2_2hA HEK293_TMG_2hB RMDN3 protein_coding processed_transcript 26.55128 22.60053 29.00307 0.5137205 0.9980362 0.3597083 2.638155 0.000000 5.1407522 0.0000000 0.8611134 9.00863932 0.08584167 0.00000000 0.17563333 0.17563333 3.273606e-25 3.273606e-25 FALSE FALSE
ENST00000560588 ENSG00000137824 HEK293_OSMI2_2hA HEK293_TMG_2hB RMDN3 protein_coding retained_intron 26.55128 22.60053 29.00307 0.5137205 0.9980362 0.3597083 1.328235 1.200220 0.9828905 0.1841052 0.1953608 -0.28556247 0.05123333 0.05286667 0.03373333 -0.01913333 3.440873e-01 3.273606e-25 FALSE FALSE
MSTRG.10572.1 ENSG00000137824 HEK293_OSMI2_2hA HEK293_TMG_2hB RMDN3 protein_coding   26.55128 22.60053 29.00307 0.5137205 0.9980362 0.3597083 2.793902 3.381101 3.3009101 0.2038964 0.2419658 -0.03452575 0.10665833 0.15003333 0.11456667 -0.03546667 3.564882e-01 3.273606e-25 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000137824 E001 1.6379602 0.0596766889 4.913103e-01 6.285948e-01 15 40735681 40735883 203 - 0.477 0.357 -0.649
ENSG00000137824 E002 1.0426094 0.3791433670 5.304881e-01 6.630953e-01 15 40735884 40735884 1 - 0.369 0.222 -1.005
ENSG00000137824 E003 1.1898584 0.1110147216 2.739005e-01 4.129991e-01 15 40735885 40735886 2 - 0.426 0.217 -1.367
ENSG00000137824 E004 3.9082764 0.0042222638 3.384575e-02 7.944660e-02 15 40735887 40735887 1 - 0.477 0.807 1.437
ENSG00000137824 E005 399.3997386 0.0059289681 5.293817e-05 2.964697e-04 15 40735888 40736337 450 - 2.495 2.670 0.581
ENSG00000137824 E006 227.3922029 0.0016684358 3.726973e-03 1.237493e-02 15 40736338 40736426 89 - 2.299 2.402 0.344
ENSG00000137824 E007 252.8875006 0.0021904843 2.758217e-02 6.717695e-02 15 40736427 40736594 168 - 2.356 2.440 0.281
ENSG00000137824 E008 171.7103390 0.0025378540 1.225276e-01 2.235559e-01 15 40737124 40737204 81 - 2.197 2.269 0.240
ENSG00000137824 E009 1.7348593 0.0079915885 3.038910e-01 4.458660e-01 15 40737205 40737287 83 - 0.522 0.356 -0.873
ENSG00000137824 E010 121.3369980 0.0002647976 1.539086e-01 2.669859e-01 15 40737288 40737341 54 - 2.052 2.113 0.204
ENSG00000137824 E011 1.2522254 0.0101955439 5.580818e-01 6.863781e-01 15 40737342 40737627 286 - 0.301 0.413 0.670
ENSG00000137824 E012 70.7639485 0.0003777457 4.023940e-01 5.461199e-01 15 40737628 40737628 1 - 1.828 1.878 0.169
ENSG00000137824 E013 134.2633454 0.0002277446 7.822282e-01 8.601820e-01 15 40737629 40737677 49 - 2.118 2.141 0.079
ENSG00000137824 E014 128.3555275 0.0002326210 7.654142e-01 8.481933e-01 15 40737678 40737726 49 - 2.108 2.113 0.019
ENSG00000137824 E015 2.1055426 0.0383686604 4.959724e-01 6.327135e-01 15 40737727 40737820 94 - 0.564 0.461 -0.494
ENSG00000137824 E016 171.8071557 0.0002274226 8.901890e-01 9.338482e-01 15 40737965 40738042 78 - 2.229 2.240 0.037
ENSG00000137824 E017 106.8366102 0.0043982148 6.940433e-01 7.949625e-01 15 40738501 40738509 9 - 2.011 2.040 0.099
ENSG00000137824 E018 158.2224076 0.0043221442 7.600903e-01 8.442847e-01 15 40738510 40738576 67 - 2.184 2.208 0.079
ENSG00000137824 E019 24.6242538 0.0155391509 8.238998e-01 8.890365e-01 15 40738577 40739680 1104 - 1.409 1.401 -0.026
ENSG00000137824 E020 108.1378283 0.0020451384 7.572208e-01 8.421062e-01 15 40740133 40740149 17 - 2.019 2.044 0.083
ENSG00000137824 E021 142.9551435 0.0003386496 2.154501e-01 3.449630e-01 15 40740150 40740193 44 - 2.169 2.146 -0.075
ENSG00000137824 E022 128.0120129 0.0003219023 4.215457e-01 5.646810e-01 15 40744047 40744093 47 - 2.118 2.108 -0.033
ENSG00000137824 E023 139.7386576 0.0002388852 5.988077e-01 7.203327e-01 15 40744094 40744149 56 - 2.131 2.162 0.103
ENSG00000137824 E024 4.4326533 0.0043710606 2.614182e-01 3.990693e-01 15 40744150 40744227 78 - 0.636 0.807 0.699
ENSG00000137824 E025 2.5505094 0.0302226759 8.693007e-01 9.200053e-01 15 40744228 40744305 78 - 0.564 0.548 -0.071
ENSG00000137824 E026 216.2906444 0.0002148950 2.651330e-01 4.031613e-01 15 40744977 40745119 143 - 2.343 2.331 -0.039
ENSG00000137824 E027 301.5134091 0.0001552052 3.886023e-06 2.834683e-05 15 40745120 40745259 140 - 2.521 2.443 -0.261
ENSG00000137824 E028 7.8062874 0.0547629593 7.360859e-01 8.266747e-01 15 40747631 40747782 152 - 0.953 0.912 -0.155
ENSG00000137824 E029 242.6957795 0.0002018976 5.707970e-08 6.074362e-07 15 40751426 40751569 144 - 2.442 2.333 -0.362
ENSG00000137824 E030 0.9890503 0.1719933137 8.946278e-01 9.366806e-01 15 40751570 40751670 101 - 0.301 0.292 -0.057
ENSG00000137824 E031 214.7959324 0.0040769475 9.501892e-03 2.754223e-02 15 40751986 40752178 193 - 2.377 2.290 -0.291
ENSG00000137824 E032 118.9213954 0.0002502278 7.959374e-02 1.589013e-01 15 40754597 40754630 34 - 2.100 2.058 -0.140
ENSG00000137824 E033 158.3394462 0.0002502639 3.922129e-02 8.959253e-02 15 40754631 40754728 98 - 2.224 2.180 -0.145
ENSG00000137824 E034 114.0145323 0.0003084874 1.760770e-01 2.961115e-01 15 40754729 40754790 62 - 2.074 2.043 -0.102
ENSG00000137824 E035 2.1798260 0.0114837692 6.848691e-01 7.877180e-01 15 40754791 40755082 292 - 0.522 0.464 -0.285
ENSG00000137824 E036 81.1996411 0.0003660485 5.515213e-02 1.182562e-01 15 40755083 40755198 116 - 1.944 1.883 -0.204
ENSG00000137824 E037 61.9988701 0.0007526250 2.406153e-01 3.748919e-01 15 40755199 40755851 653 - 1.817 1.777 -0.133