ENSG00000137815

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000389629 ENSG00000137815 HEK293_OSMI2_2hA HEK293_TMG_2hB RTF1 protein_coding protein_coding 23.07615 14.57989 32.64249 1.141957 0.7900679 1.162223 17.754761 13.7413745 24.635737 1.4483708 0.7622617 0.8417623 0.7913000 0.93836667 0.75470000 -0.1836667 3.710755e-03 1.077252e-16 FALSE TRUE
ENST00000560447 ENSG00000137815 HEK293_OSMI2_2hA HEK293_TMG_2hB RTF1 protein_coding protein_coding 23.07615 14.57989 32.64249 1.141957 0.7900679 1.162223 3.303393 0.0000000 5.102566 0.0000000 1.0372824 8.9979039 0.1135708 0.00000000 0.15500000 0.1550000 1.077252e-16 1.077252e-16 FALSE TRUE
ENST00000561076 ENSG00000137815 HEK293_OSMI2_2hA HEK293_TMG_2hB RTF1 protein_coding retained_intron 23.07615 14.57989 32.64249 1.141957 0.7900679 1.162223 1.393435 0.4638356 2.347041 0.4638356 0.8047003 2.3145186 0.0623625 0.03683333 0.07303333 0.0362000 2.620263e-01 1.077252e-16   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000137815 E001 0.0000000       15 41408408 41408581 174 +      
ENSG00000137815 E002 0.8010032 0.1495349355 9.337723e-01 9.622622e-01 15 41417095 41417131 37 + 0.244 0.266 0.170
ENSG00000137815 E003 2.3886134 0.0060591232 8.962209e-01 9.376784e-01 15 41417132 41417139 8 + 0.513 0.548 0.162
ENSG00000137815 E004 142.6568820 0.0003789234 6.083134e-04 2.563465e-03 15 41417140 41417313 174 + 2.190 2.101 -0.297
ENSG00000137815 E005 171.6525376 0.0023072589 4.536959e-03 1.464547e-02 15 41438321 41438431 111 + 2.269 2.182 -0.290
ENSG00000137815 E006 0.6192988 0.0194896693 5.871172e-01 7.104861e-01 15 41440236 41440333 98 + 0.244 0.153 -0.837
ENSG00000137815 E007 216.1686524 0.0009529790 7.725560e-03 2.309041e-02 15 41452901 41453048 148 + 2.358 2.302 -0.189
ENSG00000137815 E008 212.3925089 0.0040496239 6.894633e-01 7.913433e-01 15 41457672 41457876 205 + 2.314 2.348 0.114
ENSG00000137815 E009 132.2425400 0.0036722049 8.991562e-01 9.396545e-01 15 41464771 41464885 115 + 2.119 2.128 0.031
ENSG00000137815 E010 183.1082100 0.0001853799 7.179928e-01 8.132441e-01 15 41466141 41466252 112 + 2.252 2.280 0.094
ENSG00000137815 E011 248.0488351 0.0002392401 7.926301e-02 1.583346e-01 15 41470257 41470392 136 + 2.371 2.431 0.198
ENSG00000137815 E012 267.5846461 0.0014300291 7.562561e-01 8.413626e-01 15 41471172 41471349 178 + 2.417 2.446 0.096
ENSG00000137815 E013 0.5169874 0.0199586476 3.269406e-01 4.703848e-01 15 41474587 41474619 33 + 0.097 0.266 1.747
ENSG00000137815 E014 150.5323404 0.0002687151 3.139400e-01 4.565938e-01 15 41474620 41474668 49 + 2.185 2.174 -0.036
ENSG00000137815 E015 127.3493170 0.0002941414 8.966412e-02 1.746101e-01 15 41474669 41474702 34 + 2.122 2.086 -0.120
ENSG00000137815 E016 142.3243967 0.0002782735 7.754255e-01 8.553298e-01 15 41475525 41475612 88 + 2.151 2.160 0.033
ENSG00000137815 E017 151.7398417 0.0047486344 9.130938e-01 9.489277e-01 15 41475712 41475819 108 + 2.174 2.190 0.054
ENSG00000137815 E018 151.8703567 0.0016326151 7.163654e-01 8.120531e-01 15 41476446 41476523 78 + 2.180 2.182 0.008
ENSG00000137815 E019 124.8927358 0.0003768543 3.664997e-04 1.644660e-03 15 41477165 41477188 24 + 2.136 2.035 -0.336
ENSG00000137815 E020 193.4230266 0.0003248475 3.312894e-07 3.037693e-06 15 41477189 41477286 98 + 2.331 2.211 -0.402
ENSG00000137815 E021 167.0290422 0.0005306668 1.952367e-04 9.434259e-04 15 41477458 41477515 58 + 2.258 2.165 -0.311
ENSG00000137815 E022 2.5602924 0.0062168498 1.533632e-02 4.125141e-02 15 41477516 41477578 63 + 0.678 0.266 -2.161
ENSG00000137815 E023 2.8892181 0.0393222264 1.945078e-01 3.194006e-01 15 41478485 41478547 63 + 0.655 0.431 -1.052
ENSG00000137815 E024 174.7091834 0.0006394098 1.064640e-01 2.003327e-01 15 41478548 41478625 78 + 2.255 2.226 -0.097
ENSG00000137815 E025 0.4418608 0.0249646548 1.924877e-01 3.168842e-01 15 41478626 41478943 318 + 0.244 0.000 -10.318
ENSG00000137815 E026 183.9416954 0.0050207192 4.880621e-01 6.256810e-01 15 41479103 41479198 96 + 2.271 2.254 -0.056
ENSG00000137815 E027 166.5150597 0.0043975378 5.275447e-01 6.605885e-01 15 41480214 41480325 112 + 2.203 2.244 0.136
ENSG00000137815 E028 1302.0404591 0.0010096263 7.821673e-10 1.183540e-08 15 41480581 41483563 2983 + 3.067 3.167 0.333