ENSG00000137807

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000352331 ENSG00000137807 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF23 protein_coding protein_coding 25.42576 12.12406 40.91749 1.057312 0.9461923 1.754008 11.251509 4.475287 20.278504 0.3963590 1.3821276 2.177390 0.39450833 0.3731000 0.49500000 0.1219000 1.793965e-01 8.658983e-37 FALSE TRUE
ENST00000558585 ENSG00000137807 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF23 protein_coding processed_transcript 25.42576 12.12406 40.91749 1.057312 0.9461923 1.754008 1.057056 2.413134 0.000000 0.4246371 0.0000000 -7.920731 0.08454583 0.1965333 0.00000000 -0.1965333 8.658983e-37 8.658983e-37 FALSE TRUE
ENST00000559944 ENSG00000137807 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF23 protein_coding retained_intron 25.42576 12.12406 40.91749 1.057312 0.9461923 1.754008 1.736403 1.224738 2.572565 0.1419147 0.3454350 1.064599 0.08419583 0.1024333 0.06253333 -0.0399000 1.570376e-01 8.658983e-37   FALSE
ENST00000647715 ENSG00000137807 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF23 protein_coding protein_coding 25.42576 12.12406 40.91749 1.057312 0.9461923 1.754008 6.028264 2.812538 9.346390 0.3020892 0.2476108 1.728959 0.22811250 0.2312000 0.22890000 -0.0023000 9.926469e-01 8.658983e-37 FALSE TRUE
MSTRG.11129.6 ENSG00000137807 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF23 protein_coding   25.42576 12.12406 40.91749 1.057312 0.9461923 1.754008 3.010601 0.000000 5.678739 0.0000000 0.7052286 9.151965 0.09730417 0.0000000 0.13943333 0.1394333 2.860070e-18 8.658983e-37 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000137807 E001 0.0000000       15 69414246 69414272 27 +      
ENSG00000137807 E002 0.1515154 0.0429011524 1.000000e+00   15 69414273 69414292 20 + 0.069 0.000 -8.799
ENSG00000137807 E003 0.7427016 0.0155477996 2.308143e-01 3.634444e-01 15 69414293 69414303 11 + 0.271 0.000 -11.099
ENSG00000137807 E004 6.0646592 0.0026498111 3.837016e-02 8.804853e-02 15 69414304 69414324 21 + 0.859 0.537 -1.350
ENSG00000137807 E005 6.2119083 0.0025732087 3.215770e-02 7.616250e-02 15 69414325 69414327 3 + 0.870 0.537 -1.390
ENSG00000137807 E006 13.4902590 0.0012639690 1.595150e-02 4.262230e-02 15 69414328 69414348 21 + 1.156 0.888 -0.987
ENSG00000137807 E007 27.0471133 0.0007057127 1.196140e-03 4.627360e-03 15 69414349 69414358 10 + 1.442 1.178 -0.923
ENSG00000137807 E008 54.7439209 0.0003980971 2.165230e-06 1.671065e-05 15 69414359 69414380 22 + 1.743 1.464 -0.951
ENSG00000137807 E009 92.8920095 0.0015627231 1.993607e-07 1.910383e-06 15 69414381 69414476 96 + 1.964 1.714 -0.841
ENSG00000137807 E010 104.6009252 0.0015400101 1.408728e-05 9.039710e-05 15 69415994 69416063 70 + 2.004 1.815 -0.638
ENSG00000137807 E011 135.1709460 0.0002423926 6.906691e-07 5.937792e-06 15 69417383 69417511 129 + 2.112 1.938 -0.584
ENSG00000137807 E012 134.4834807 0.0002420498 4.341784e-08 4.741126e-07 15 69421647 69421752 106 + 2.112 1.916 -0.660
ENSG00000137807 E013 3.0894622 0.0277712025 2.981712e-02 7.160487e-02 15 69421753 69421916 164 + 0.649 0.207 -2.503
ENSG00000137807 E014 151.4861786 0.0002419261 4.627394e-09 6.073058e-08 15 69421992 69422128 137 + 2.166 1.967 -0.665
ENSG00000137807 E015 130.6928859 0.0003671553 6.285764e-03 1.936157e-02 15 69422326 69422435 110 + 2.080 1.992 -0.296
ENSG00000137807 E016 0.0000000       15 69422900 69422908 9 +      
ENSG00000137807 E017 0.1482932 0.0416128592 1.321293e-01   15 69422909 69423034 126 + 0.000 0.207 12.138
ENSG00000137807 E018 0.0000000       15 69423035 69423158 124 +      
ENSG00000137807 E019 137.2159294 0.0019194943 5.793822e-01 7.042944e-01 15 69423159 69423329 171 + 2.082 2.074 -0.028
ENSG00000137807 E020 16.0947029 0.0011411911 5.462941e-01 6.764918e-01 15 69425282 69425323 42 + 1.187 1.141 -0.163
ENSG00000137807 E021 2.5078515 0.0057700094 7.061386e-01 8.043535e-01 15 69425875 69426069 195 + 0.512 0.453 -0.295
ENSG00000137807 E022 135.3298514 0.0082420620 9.898447e-02 1.889249e-01 15 69426070 69426182 113 + 2.094 2.013 -0.271
ENSG00000137807 E023 1.7380815 0.0079864386 7.239077e-01 8.176217e-01 15 69426183 69426335 153 + 0.378 0.453 0.405
ENSG00000137807 E024 165.9839530 0.0053050978 2.262011e-04 1.075576e-03 15 69426336 69426457 122 + 2.200 2.033 -0.560
ENSG00000137807 E025 3.7448377 0.0121281591 7.072575e-01 8.052151e-01 15 69426458 69426656 199 + 0.596 0.670 0.321
ENSG00000137807 E026 0.1515154 0.0429011524 1.000000e+00   15 69427370 69427499 130 + 0.069 0.000 -8.777
ENSG00000137807 E027 150.9795827 0.0055492889 4.402196e-02 9.842828e-02 15 69429111 69429213 103 + 2.142 2.055 -0.288
ENSG00000137807 E028 159.5013993 0.0015422609 6.644999e-04 2.768706e-03 15 69435483 69435562 80 + 2.172 2.056 -0.391
ENSG00000137807 E029 185.7888594 0.0002459740 4.744453e-03 1.521725e-02 15 69435652 69435771 120 + 2.228 2.155 -0.245
ENSG00000137807 E030 0.0000000       15 69435772 69435782 11 +      
ENSG00000137807 E031 88.9212946 0.0007388597 1.473651e-01 2.581188e-01 15 69436138 69436148 11 + 1.905 1.853 -0.173
ENSG00000137807 E032 175.6205214 0.0002906389 9.298012e-02 1.797893e-01 15 69436149 69436261 113 + 2.196 2.157 -0.129
ENSG00000137807 E033 199.3342419 0.0017379199 8.317260e-03 2.458543e-02 15 69436564 69436722 159 + 2.259 2.180 -0.264
ENSG00000137807 E034 194.4302029 0.0034633716 9.678954e-01 9.839231e-01 15 69438248 69438405 158 + 2.226 2.239 0.046
ENSG00000137807 E035 237.3821489 0.0019679310 1.513034e-02 4.078074e-02 15 69439904 69440077 174 + 2.290 2.384 0.314
ENSG00000137807 E036 238.6724962 0.0005627088 6.592656e-02 1.365795e-01 15 69440308 69440487 180 + 2.301 2.367 0.220
ENSG00000137807 E037 83.2826916 0.0003435239 1.208998e-01 2.212358e-01 15 69440768 69441079 312 + 1.843 1.925 0.278
ENSG00000137807 E038 12.4658195 0.0261151217 4.644112e-01 6.041303e-01 15 69443605 69444754 1150 + 1.095 1.007 -0.323
ENSG00000137807 E039 1.5918646 0.0114902024 8.412542e-01 9.009678e-01 15 69444755 69444789 35 + 0.378 0.347 -0.179
ENSG00000137807 E040 98.9146775 0.0009693071 1.696530e-03 6.272370e-03 15 69444790 69444810 21 + 1.901 2.045 0.484
ENSG00000137807 E041 271.5170142 0.0001664497 2.256492e-07 2.141605e-06 15 69444811 69445041 231 + 2.335 2.473 0.459
ENSG00000137807 E042 170.8532314 0.0002378531 1.693444e-02 4.478719e-02 15 69446009 69446091 83 + 2.151 2.239 0.294
ENSG00000137807 E043 86.2652896 0.0073873363 8.777477e-02 1.717544e-01 15 69446283 69446285 3 + 1.850 1.966 0.388
ENSG00000137807 E044 107.2466717 0.0004864798 1.054813e-02 3.008826e-02 15 69446286 69446299 14 + 1.943 2.057 0.382
ENSG00000137807 E045 152.6708277 0.0021175006 5.475644e-03 1.722334e-02 15 69446300 69446364 65 + 2.092 2.214 0.408
ENSG00000137807 E046 10.1753753 0.0338633008 3.482013e-01 4.924210e-01 15 69446365 69446430 66 + 1.023 0.888 -0.504
ENSG00000137807 E047 15.7436649 0.0080240733 9.810199e-01 9.921434e-01 15 69446431 69446587 157 + 1.162 1.178 0.058
ENSG00000137807 E048 24.1622271 0.0155232566 3.342430e-01 4.779840e-01 15 69446588 69446870 283 + 1.317 1.424 0.369
ENSG00000137807 E049 184.3075345 0.0005927853 9.242617e-06 6.192262e-05 15 69446871 69446941 71 + 2.163 2.313 0.499
ENSG00000137807 E050 0.6266857 0.0168638964 2.369600e-01 3.706507e-01 15 69446942 69446950 9 + 0.129 0.347 1.819
ENSG00000137807 E051 415.0359807 0.0040678915 1.978885e-14 6.233712e-13 15 69447792 69448454 663 + 2.470 2.747 0.923