ENSG00000137776

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000380516 ENSG00000137776 HEK293_OSMI2_2hA HEK293_TMG_2hB SLTM protein_coding protein_coding 30.98983 23.42185 38.44998 0.8529888 1.818965 0.7148872 11.961397 9.9143433 15.0668543 0.2817626 0.4078953 0.6032919 0.39282500 0.42506667 0.39270000 -0.03236667 7.097901e-01 3.24556e-15 FALSE TRUE
ENST00000432750 ENSG00000137776 HEK293_OSMI2_2hA HEK293_TMG_2hB SLTM protein_coding protein_coding 30.98983 23.42185 38.44998 0.8529888 1.818965 0.7148872 2.454641 2.8433128 1.5617361 0.5646632 0.2230167 -0.8602789 0.08745833 0.12293333 0.04033333 -0.08260000 1.120091e-02 3.24556e-15 FALSE TRUE
ENST00000493062 ENSG00000137776 HEK293_OSMI2_2hA HEK293_TMG_2hB SLTM protein_coding retained_intron 30.98983 23.42185 38.44998 0.8529888 1.818965 0.7148872 1.536721 4.6640851 0.0000000 1.5331193 0.0000000 -8.8685402 0.06478333 0.19770000 0.00000000 -0.19770000 3.245560e-15 3.24556e-15 FALSE FALSE
ENST00000558052 ENSG00000137776 HEK293_OSMI2_2hA HEK293_TMG_2hB SLTM protein_coding retained_intron 30.98983 23.42185 38.44998 0.8529888 1.818965 0.7148872 2.393920 2.1290256 0.5770127 0.9068687 0.5770127 -1.8654901 0.07763333 0.08826667 0.01383333 -0.07443333 1.545434e-01 3.24556e-15 FALSE TRUE
MSTRG.10930.11 ENSG00000137776 HEK293_OSMI2_2hA HEK293_TMG_2hB SLTM protein_coding   30.98983 23.42185 38.44998 0.8529888 1.818965 0.7148872 1.974980 0.5401425 1.5914073 0.2650697 0.2194352 1.5414629 0.05848333 0.02263333 0.04206667 0.01943333 3.906815e-01 3.24556e-15 FALSE TRUE
MSTRG.10930.8 ENSG00000137776 HEK293_OSMI2_2hA HEK293_TMG_2hB SLTM protein_coding   30.98983 23.42185 38.44998 0.8529888 1.818965 0.7148872 3.245896 0.8484038 7.5344615 0.4471017 0.3733536 3.1356895 0.09592083 0.03746667 0.19763333 0.16016667 2.263090e-01 3.24556e-15 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000137776 E001 139.5759334 0.0088798752 1.778964e-08 2.093548e-07 15 58879050 58879418 369 - 1.978 2.304 1.092
ENSG00000137776 E002 56.4130444 0.0069906333 1.287172e-06 1.044061e-05 15 58879419 58879424 6 - 1.597 1.910 1.061
ENSG00000137776 E003 52.9819354 0.0099031545 3.742199e-06 2.742229e-05 15 58879425 58879428 4 - 1.560 1.891 1.122
ENSG00000137776 E004 55.7559147 0.0108756623 7.854615e-07 6.673693e-06 15 58879429 58879431 3 - 1.566 1.924 1.213
ENSG00000137776 E005 137.1865238 0.0036629057 4.401411e-14 1.315818e-12 15 58879432 58879548 117 - 1.968 2.299 1.108
ENSG00000137776 E006 89.3360236 0.0015284631 4.886056e-14 1.451770e-12 15 58879549 58879559 11 - 1.787 2.112 1.093
ENSG00000137776 E007 255.9593598 0.0044511506 1.033518e-12 2.531637e-11 15 58879560 58879757 198 - 2.260 2.551 0.972
ENSG00000137776 E008 146.0105363 0.0002481301 3.635319e-20 2.360988e-18 15 58879758 58879776 19 - 2.018 2.305 0.960
ENSG00000137776 E009 142.0812086 0.0002737237 2.314483e-24 2.377029e-22 15 58879777 58879854 78 - 1.986 2.308 1.076
ENSG00000137776 E010 145.5152211 0.0002372927 2.219139e-19 1.325376e-17 15 58879855 58879979 125 - 2.019 2.300 0.941
ENSG00000137776 E011 156.3108180 0.0017789824 1.087629e-03 4.261505e-03 15 58879980 58880107 128 - 2.131 2.258 0.426
ENSG00000137776 E012 1.1543840 0.0158126490 6.373322e-01 7.512436e-01 15 58883479 58883625 147 - 0.349 0.269 -0.524
ENSG00000137776 E013 228.6636635 0.0091232353 1.322744e-01 2.372762e-01 15 58883626 58883786 161 - 2.311 2.408 0.327
ENSG00000137776 E014 296.8941418 0.0042701798 2.930424e-01 4.340721e-01 15 58886975 58887119 145 - 2.442 2.499 0.188
ENSG00000137776 E015 0.5106578 0.2293286395 3.726544e-01 5.170898e-01 15 58887120 58887124 5 - 0.096 0.270 1.804
ENSG00000137776 E016 202.1686460 0.0004243858 1.679462e-01 2.855250e-01 15 58887226 58887291 66 - 2.277 2.327 0.167
ENSG00000137776 E017 294.5419251 0.0027197743 5.328082e-02 1.149869e-01 15 58887292 58887456 165 - 2.427 2.505 0.261
ENSG00000137776 E018 204.9293475 0.0010156323 2.432706e-01 3.780105e-01 15 58887457 58887540 84 - 2.282 2.330 0.159
ENSG00000137776 E019 262.9772885 0.0010156495 3.929008e-01 5.367892e-01 15 58888385 58888555 171 - 2.397 2.433 0.122
ENSG00000137776 E020 0.7341688 0.3137564858 1.415912e-01 2.502077e-01 15 58888556 58888573 18 - 0.349 0.000 -13.469
ENSG00000137776 E021 0.7447779 0.0838065006 7.475078e-02 1.511351e-01 15 58888574 58888729 156 - 0.349 0.000 -13.475
ENSG00000137776 E022 0.7427016 0.0155289169 6.204704e-02 1.300679e-01 15 58889144 58889429 286 - 0.349 0.000 -13.474
ENSG00000137776 E023 216.4659780 0.0005675253 9.467918e-01 9.705946e-01 15 58889430 58889554 125 - 2.323 2.335 0.039
ENSG00000137776 E024 236.2019445 0.0003025832 3.225476e-01 4.658438e-01 15 58890281 58890461 181 - 2.369 2.357 -0.037
ENSG00000137776 E025 220.4330330 0.0011051038 7.193922e-02 1.465574e-01 15 58892897 58893060 164 - 2.350 2.312 -0.128
ENSG00000137776 E026 171.2760841 0.0017266943 3.689313e-01 5.133524e-01 15 58893279 58893364 86 - 2.233 2.216 -0.056
ENSG00000137776 E027 145.4861407 0.0027852996 1.518948e-01 2.642444e-01 15 58893821 58893901 81 - 2.175 2.132 -0.144
ENSG00000137776 E028 98.7137964 0.0003022715 1.391675e-02 3.803739e-02 15 58893902 58893925 24 - 2.021 1.943 -0.263
ENSG00000137776 E029 123.8043702 0.0025495918 2.257738e-01 3.573072e-01 15 58893926 58893987 62 - 2.100 2.065 -0.119
ENSG00000137776 E030 120.1217163 0.0055871632 1.901117e-01 3.139203e-01 15 58894090 58894157 68 - 2.094 2.044 -0.168
ENSG00000137776 E031 99.4811303 0.0035654889 1.514444e-02 4.081296e-02 15 58894158 58894188 31 - 2.031 1.931 -0.335
ENSG00000137776 E032 73.6679664 0.0010385143 1.210258e-02 3.378170e-02 15 58894189 58894193 5 - 1.903 1.804 -0.335
ENSG00000137776 E033 76.3880744 0.0004319631 1.791026e-02 4.694306e-02 15 58894433 58894458 26 - 1.914 1.826 -0.294
ENSG00000137776 E034 152.4349551 0.0002014536 2.058871e-03 7.407876e-03 15 58894459 58894582 124 - 2.208 2.128 -0.265
ENSG00000137776 E035 154.1361895 0.0001999592 4.597583e-05 2.613805e-04 15 58897115 58897233 119 - 2.223 2.114 -0.364
ENSG00000137776 E036 0.9922594 0.0129136730 8.449641e-01 9.035465e-01 15 58897234 58897564 331 - 0.298 0.269 -0.202
ENSG00000137776 E037 0.8189741 0.0234131355 4.140091e-01 5.574294e-01 15 58897982 58898802 821 - 0.298 0.155 -1.202
ENSG00000137776 E038 87.2829144 0.0002852292 1.804953e-03 6.614750e-03 15 58898803 58898815 13 - 1.979 1.869 -0.371
ENSG00000137776 E039 108.7408232 0.0002472224 1.116709e-03 4.359215e-03 15 58898816 58898852 37 - 2.070 1.968 -0.344
ENSG00000137776 E040 9.5685976 0.0355114236 4.378343e-03 1.420121e-02 15 58898853 58899468 616 - 1.142 0.724 -1.581
ENSG00000137776 E041 178.7499223 0.0003347118 4.482171e-07 4.002139e-06 15 58899469 58899610 142 - 2.294 2.162 -0.439
ENSG00000137776 E042 155.7865853 0.0049202727 2.578752e-03 9.000475e-03 15 58899611 58899704 94 - 2.230 2.110 -0.402
ENSG00000137776 E043 80.2306342 0.0072420784 3.106982e-03 1.058096e-02 15 58899705 58899709 5 - 1.955 1.797 -0.531
ENSG00000137776 E044 121.7679303 0.0002956557 1.821622e-10 3.073080e-09 15 58899710 58899790 81 - 2.152 1.943 -0.699
ENSG00000137776 E045 126.6713337 0.0003759402 4.151149e-07 3.731543e-06 15 58899791 58899880 90 - 2.154 1.995 -0.532
ENSG00000137776 E046 63.8936955 0.0004218593 4.591817e-04 2.003145e-03 15 58899881 58899883 3 - 1.860 1.709 -0.508
ENSG00000137776 E047 72.1528778 0.0020578863 1.770719e-04 8.656964e-04 15 58899884 58899937 54 - 1.915 1.745 -0.574
ENSG00000137776 E048 13.5770094 0.0174130361 2.363476e-03 8.348467e-03 15 58900417 58900758 342 - 1.267 0.920 -1.260
ENSG00000137776 E049 2.2990787 0.0061761045 4.087274e-02 9.265879e-02 15 58900968 58901259 292 - 0.624 0.269 -1.904
ENSG00000137776 E050 95.6989050 0.0098520261 3.125885e-03 1.063580e-02 15 58901260 58901287 28 - 2.036 1.867 -0.565
ENSG00000137776 E051 103.0926401 0.0022685505 1.961843e-08 2.291684e-07 15 58912563 58912610 48 - 2.088 1.855 -0.785
ENSG00000137776 E052 6.0206363 0.0027107848 9.426248e-03 2.734681e-02 15 58912611 58912801 191 - 0.949 0.602 -1.396
ENSG00000137776 E053 115.5557828 0.0049942096 4.065255e-07 3.660410e-06 15 58913499 58913556 58 - 2.141 1.904 -0.797
ENSG00000137776 E054 174.8122318 0.0022008472 9.370528e-11 1.661256e-09 15 58913557 58913696 140 - 2.314 2.091 -0.745
ENSG00000137776 E055 1.8832542 0.0073436068 3.725932e-01 5.170389e-01 15 58913697 58913776 80 - 0.508 0.359 -0.788
ENSG00000137776 E056 0.8984834 0.0167838627 3.661380e-02 8.473978e-02 15 58916574 58916934 361 - 0.395 0.000 -13.738
ENSG00000137776 E057 130.0289559 0.0002589382 1.563858e-12 3.710308e-11 15 58916935 58916999 65 - 2.186 1.962 -0.753
ENSG00000137776 E058 2.3262609 0.0079424140 4.185594e-02 9.445820e-02 15 58917000 58917020 21 - 0.624 0.269 -1.903
ENSG00000137776 E059 0.1515154 0.0423149246 7.866345e-01   15 58921446 58921584 139 - 0.096 0.000 -11.153
ENSG00000137776 E060 3.9586198 0.0845072622 9.593483e-01 9.785002e-01 15 58932152 58932355 204 - 0.695 0.714 0.081
ENSG00000137776 E061 138.5700782 0.0002707331 1.188479e-10 2.072284e-09 15 58932356 58932443 88 - 2.206 2.010 -0.656
ENSG00000137776 E062 0.8731125 0.3887083871 1.364974e-01 2.431890e-01 15 58933050 58933121 72 - 0.393 0.000 -13.724
ENSG00000137776 E063 120.5397478 0.0016029393 7.097362e-06 4.879955e-05 15 58933404 58933679 276 - 2.134 1.973 -0.540