ENSG00000137770

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000260327 ENSG00000137770 HEK293_OSMI2_2hA HEK293_TMG_2hB CTDSPL2 protein_coding protein_coding 13.49443 2.161768 24.32489 0.6203904 1.347571 3.486085 5.25701037 0.69185063 8.56698418 0.35000732 0.95074508 3.611235 0.45869167 0.35310000 0.3518667 -0.001233333 9.066244e-01 3.292729e-13 FALSE TRUE
ENST00000558791 ENSG00000137770 HEK293_OSMI2_2hA HEK293_TMG_2hB CTDSPL2 protein_coding protein_coding 13.49443 2.161768 24.32489 0.6203904 1.347571 3.486085 5.04742316 0.03705440 8.82411312 0.03705440 0.84902227 7.552612 0.20617083 0.02256667 0.3615333 0.338966667 3.292729e-13 3.292729e-13 FALSE FALSE
ENST00000558966 ENSG00000137770 HEK293_OSMI2_2hA HEK293_TMG_2hB CTDSPL2 protein_coding protein_coding 13.49443 2.161768 24.32489 0.6203904 1.347571 3.486085 0.08197614 0.44290643 0.02836126 0.44290643 0.02836126 -3.561491 0.06563750 0.26993333 0.0013000 -0.268633333 6.770825e-01 3.292729e-13 FALSE TRUE
ENST00000559738 ENSG00000137770 HEK293_OSMI2_2hA HEK293_TMG_2hB CTDSPL2 protein_coding processed_transcript 13.49443 2.161768 24.32489 0.6203904 1.347571 3.486085 0.14363358 0.79629406 0.00000000 0.79629406 0.00000000 -6.333234 0.04752917 0.23436667 0.0000000 -0.234366667 3.921207e-01 3.292729e-13   FALSE
MSTRG.10678.1 ENSG00000137770 HEK293_OSMI2_2hA HEK293_TMG_2hB CTDSPL2 protein_coding   13.49443 2.161768 24.32489 0.6203904 1.347571 3.486085 1.85989662 0.07121321 4.59177655 0.07121321 0.61122923 5.824333 0.12363333 0.04920000 0.1898000 0.140600000 1.623417e-01 3.292729e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000137770 E001 7.9134355 0.0024804200 1.369119e-02 3.751780e-02 15 44427614 44427621 8 + 0.694 0.379 -1.500
ENSG00000137770 E002 9.1064170 0.0034321229 6.120782e-03 1.892517e-02 15 44427622 44427628 7 + 0.745 0.379 -1.706
ENSG00000137770 E003 10.8954027 0.0057424626 1.260173e-02 3.497296e-02 15 44427629 44427641 13 + 0.805 0.579 -0.949
ENSG00000137770 E004 37.2924268 0.0005585409 1.073367e-07 1.084215e-06 15 44427642 44427692 51 + 1.294 0.902 -1.420
ENSG00000137770 E005 55.6571805 0.0012742098 6.975146e-11 1.263550e-09 15 44427693 44427772 80 + 1.460 1.032 -1.511
ENSG00000137770 E006 0.1472490 0.0467746513 6.564366e-01   15 44427793 44427807 15 + 0.032 0.000 -15.607
ENSG00000137770 E007 0.1472490 0.0467746513 6.564366e-01   15 44427808 44427813 6 + 0.032 0.000 -15.607
ENSG00000137770 E008 0.2924217 0.0276690899 1.000000e+00   15 44427814 44427893 80 + 0.061 0.000 -16.607
ENSG00000137770 E009 0.1451727 0.0443543932 6.549277e-01   15 44427894 44428005 112 + 0.032 0.000 -15.607
ENSG00000137770 E010 0.0000000       15 44428006 44428095 90 +      
ENSG00000137770 E011 34.3209004 0.0838785476 1.810613e-02 4.735946e-02 15 44458991 44459002 12 + 1.249 1.096 -0.547
ENSG00000137770 E012 101.0679637 0.0635398907 7.856603e-04 3.208264e-03 15 44459003 44459200 198 + 1.705 1.513 -0.652
ENSG00000137770 E013 0.7792333 0.0394870717 5.086833e-01 6.440498e-01 15 44470469 44470574 106 + 0.115 0.379 2.200
ENSG00000137770 E014 83.8789072 0.0004320369 5.458400e-06 3.852317e-05 15 44484224 44484362 139 + 1.616 1.618 0.006
ENSG00000137770 E015 34.2172909 0.0006295100 6.795719e-02 1.399759e-01 15 44486551 44486553 3 + 1.233 1.368 0.472
ENSG00000137770 E016 94.7026931 0.0003166529 1.492978e-06 1.194578e-05 15 44486554 44486700 147 + 1.667 1.673 0.018
ENSG00000137770 E017 123.5037038 0.0002917506 5.152708e-11 9.554322e-10 15 44490784 44490991 208 + 1.786 1.710 -0.257
ENSG00000137770 E018 40.0889643 0.0005305501 3.323703e-05 1.954755e-04 15 44490992 44490999 8 + 1.315 1.175 -0.495
ENSG00000137770 E019 68.1902058 0.0020179820 3.851039e-06 2.812304e-05 15 44496380 44496458 79 + 1.534 1.461 -0.250
ENSG00000137770 E020 79.2165970 0.0003240509 4.851348e-08 5.247050e-07 15 44497027 44497138 112 + 1.599 1.501 -0.335
ENSG00000137770 E021 71.4402502 0.0005112947 8.697358e-07 7.317856e-06 15 44499727 44499813 87 + 1.553 1.481 -0.247
ENSG00000137770 E022 2.3416776 0.1592268487 2.116088e-01 3.403908e-01 15 44501962 44502048 87 + 0.344 0.000 -19.600
ENSG00000137770 E023 6.9658738 0.0029336568 1.176332e-01 2.165635e-01 15 44503424 44503879 456 + 0.645 0.579 -0.292
ENSG00000137770 E024 64.7417238 0.0025989217 5.893386e-03 1.833037e-02 15 44514598 44514660 63 + 1.500 1.603 0.354
ENSG00000137770 E025 66.4253158 0.0057837922 2.894529e-02 6.989750e-02 15 44514765 44514844 80 + 1.508 1.646 0.473
ENSG00000137770 E026 2.1068920 0.0069550409 6.876326e-01 7.899312e-01 15 44518654 44518864 211 + 0.298 0.379 0.500
ENSG00000137770 E027 62.7498773 0.0357480740 2.507172e-01 3.867821e-01 15 44519169 44519223 55 + 1.482 1.648 0.567
ENSG00000137770 E028 58.6165275 0.0006749803 1.241258e-03 4.780885e-03 15 44519224 44519295 72 + 1.461 1.520 0.200
ENSG00000137770 E029 2.6207590 0.0058575221 8.679345e-01 9.190719e-01 15 44519637 44521263 1627 + 0.330 0.579 1.294
ENSG00000137770 E030 0.4545463 0.6599163184 1.000000e+00 1.000000e+00 15 44521264 44521310 47 + 0.090 0.000 -17.207
ENSG00000137770 E031 73.5492620 0.0021301553 6.727970e-02 1.388295e-01 15 44521311 44521406 96 + 1.546 1.743 0.671
ENSG00000137770 E032 810.6574952 0.0634640774 9.607659e-06 6.413468e-05 15 44524109 44529038 4930 + 2.518 3.125 2.019