ENSG00000137713

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000341980 ENSG00000137713 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP2R1B protein_coding protein_coding 22.02136 9.333813 31.22346 1.499988 0.986361 1.741009 6.944738 1.583983 11.216623 0.430939 0.8387540 2.816215 0.26822083 0.1816333 0.35826667 0.17663333 1.218663e-01 3.101488e-11 FALSE  
ENST00000527614 ENSG00000137713 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP2R1B protein_coding protein_coding 22.02136 9.333813 31.22346 1.499988 0.986361 1.741009 10.934190 7.193384 15.696237 1.715786 0.8564832 1.124591 0.55530000 0.7580000 0.50196667 -0.25603333 5.479609e-02 3.101488e-11 FALSE  
ENST00000534521 ENSG00000137713 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP2R1B protein_coding nonsense_mediated_decay 22.02136 9.333813 31.22346 1.499988 0.986361 1.741009 2.205183 0.000000 2.609649 0.000000 0.3517443 8.033230 0.07554167 0.0000000 0.08443333 0.08443333 3.101488e-11 3.101488e-11 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000137713 E001 1.3379506 0.2443378352 6.384871e-01 7.521163e-01 11 111726908 111726913 6 - 0.302 0.480 1.004
ENSG00000137713 E002 3.1897656 0.3088257532 1.604352e-01 2.757072e-01 11 111726914 111726969 56 - 0.417 0.849 1.913
ENSG00000137713 E003 3.8552472 0.2124200727 7.376382e-02 1.495461e-01 11 111726970 111727057 88 - 0.449 0.923 2.023
ENSG00000137713 E004 0.5975289 0.0351074409 2.164451e-01 3.461408e-01 11 111735281 111735325 45 - 0.256 0.000 -10.768
ENSG00000137713 E005 3.3191335 0.0767048028 2.760828e-01 4.154894e-01 11 111737448 111737569 122 - 0.533 0.756 0.966
ENSG00000137713 E006 839.7369974 0.0065298020 1.749434e-06 1.378467e-05 11 111737877 111741054 3178 - 2.824 3.018 0.645
ENSG00000137713 E007 242.8505031 0.0004234098 4.510183e-01 5.920172e-01 11 111741055 111741320 266 - 2.342 2.400 0.195
ENSG00000137713 E008 236.8787421 0.0005367411 5.019494e-01 6.380997e-01 11 111741321 111741516 196 - 2.332 2.391 0.196
ENSG00000137713 E009 116.5223060 0.0021607315 1.917244e-01 3.159258e-01 11 111741517 111741547 31 - 2.014 2.112 0.328
ENSG00000137713 E010 155.4962237 0.0002325789 5.224741e-01 6.562867e-01 11 111741548 111741612 65 - 2.151 2.211 0.203
ENSG00000137713 E011 99.0619283 0.0013726413 9.737318e-01 9.876207e-01 11 111742053 111742056 4 - 1.961 2.001 0.135
ENSG00000137713 E012 174.5035477 0.0008119402 5.857602e-01 7.093895e-01 11 111742057 111742144 88 - 2.201 2.258 0.191
ENSG00000137713 E013 5.1273523 0.0036107550 4.545759e-02 1.010360e-01 11 111742145 111742522 378 - 0.834 0.560 -1.145
ENSG00000137713 E014 208.7993665 0.0002418275 5.766438e-01 7.020276e-01 11 111742523 111742665 143 - 2.288 2.314 0.088
ENSG00000137713 E015 168.8246738 0.0002525464 5.568610e-01 6.854194e-01 11 111743376 111743530 155 - 2.195 2.218 0.078
ENSG00000137713 E016 83.5312026 0.0003484560 4.761230e-01 6.148109e-01 11 111747954 111748014 61 - 1.877 1.947 0.234
ENSG00000137713 E017 136.7890732 0.0043967281 5.100970e-01 6.453436e-01 11 111752159 111752332 174 - 2.111 2.111 0.001
ENSG00000137713 E018 127.9235786 0.0012210667 7.664449e-02 1.541229e-01 11 111753443 111753577 135 - 2.093 2.066 -0.088
ENSG00000137713 E019 115.1933985 0.0002696226 6.828474e-01 7.862045e-01 11 111754499 111754569 71 - 2.030 2.056 0.088
ENSG00000137713 E020 135.6080141 0.0007227771 6.485935e-02 1.348083e-01 11 111754980 111755094 115 - 2.116 2.090 -0.086
ENSG00000137713 E021 141.0175749 0.0021804574 5.429715e-02 1.167665e-01 11 111755295 111755450 156 - 2.136 2.093 -0.144
ENSG00000137713 E022 64.6228490 0.0055114389 8.444927e-02 1.665244e-01 11 111759804 111759813 10 - 1.811 1.740 -0.239
ENSG00000137713 E023 133.5078372 0.0023770936 2.250738e-04 1.070646e-03 11 111759814 111759951 138 - 2.135 2.018 -0.391
ENSG00000137713 E024 157.5207281 0.0002140687 6.175793e-11 1.126828e-09 11 111760819 111760955 137 - 2.220 2.052 -0.563
ENSG00000137713 E025 148.9150560 0.0002425717 9.074891e-10 1.356058e-08 11 111760956 111761051 96 - 2.194 2.033 -0.539
ENSG00000137713 E026 0.4460135 0.0414375718 3.506838e-01 4.948677e-01 11 111761119 111761291 173 - 0.205 0.000 -10.353
ENSG00000137713 E027 136.3050788 0.0003461200 8.180531e-08 8.450257e-07 11 111764805 111764905 101 - 2.152 2.007 -0.486
ENSG00000137713 E028 120.4202607 0.0053998273 1.274895e-03 4.893628e-03 11 111765294 111765384 91 - 2.094 1.955 -0.465
ENSG00000137713 E029 0.6017953 0.1644938866 2.632691e-01 4.011545e-01 11 111765798 111766247 450 - 0.257 0.000 -10.772
ENSG00000137713 E030 91.0520617 0.0082877143 2.586068e-02 6.365526e-02 11 111766248 111766389 142 - 1.967 1.856 -0.376