ENSG00000137710

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000532461 ENSG00000137710 HEK293_OSMI2_2hA HEK293_TMG_2hB RDX protein_coding retained_intron 32.83318 5.131205 50.44665 0.2996934 2.284418 3.294866 0.9858942 2.7272024 0.000000 0.4029476 0.0000000 -8.09655830 0.2090833 0.5258667 0.00000000 -0.5258667 7.511516e-45 7.511516e-45 FALSE TRUE
ENST00000533961 ENSG00000137710 HEK293_OSMI2_2hA HEK293_TMG_2hB RDX protein_coding retained_intron 32.83318 5.131205 50.44665 0.2996934 2.284418 3.294866 6.9139161 0.0000000 9.568087 0.0000000 0.9249429 9.90359377 0.1106875 0.0000000 0.18906667 0.1890667 7.776255e-21 7.511516e-45 FALSE TRUE
ENST00000645495 ENSG00000137710 HEK293_OSMI2_2hA HEK293_TMG_2hB RDX protein_coding protein_coding 32.83318 5.131205 50.44665 0.2996934 2.284418 3.294866 16.6834803 0.8932837 35.277868 0.2293560 1.6233171 5.28784927 0.4253000 0.1808000 0.70190000 0.5211000 2.262644e-06 7.511516e-45 FALSE TRUE
MSTRG.6285.12 ENSG00000137710 HEK293_OSMI2_2hA HEK293_TMG_2hB RDX protein_coding   32.83318 5.131205 50.44665 0.2996934 2.284418 3.294866 4.3804515 1.1880891 1.125221 0.1718155 1.1252209 -0.07776217 0.1648417 0.2309000 0.02103333 -0.2098667 3.692429e-02 7.511516e-45 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000137710 E001 0.0000000       11 109864295 109864719 425 -      
ENSG00000137710 E002 0.0000000       11 109990756 109990789 34 -      
ENSG00000137710 E003 0.0000000       11 110124059 110124270 212 -      
ENSG00000137710 E004 0.1472490 0.0436481863 5.207770e-01   11 110131436 110131730 295 - 0.034 0.000 -7.195
ENSG00000137710 E005 0.5202097 0.0206512658 1.726618e-01 2.916682e-01 11 110174880 110174966 87 - 0.065 0.365 3.028
ENSG00000137710 E006 0.7061804 0.1094855115 3.065130e-02 7.323584e-02 11 110174967 110175234 268 - 0.065 0.562 4.036
ENSG00000137710 E007 0.3030308 0.3550759883 9.329883e-01   11 110181792 110181838 47 - 0.065 0.000 -9.106
ENSG00000137710 E008 1.7766884 0.0095747475 8.097812e-05 4.326179e-04 11 110185073 110185344 272 - 0.147 0.948 4.287
ENSG00000137710 E009 3.3340977 0.0109252622 1.244744e-03 4.792754e-03 11 110185345 110185619 275 - 0.328 1.008 3.025
ENSG00000137710 E010 0.1817044 0.0407645364 2.269086e-02   11 110195561 110195589 29 - 0.000 0.364 14.087
ENSG00000137710 E011 4.0716261 0.0149789404 1.437519e-04 7.198501e-04 11 110195590 110196165 576 - 0.360 1.109 3.198
ENSG00000137710 E012 4.6177452 0.0039660101 6.425874e-06 4.463618e-05 11 110199581 110199678 98 - 0.375 1.189 3.399
ENSG00000137710 E013 0.4355181 0.5680533834 1.000000e+00 1.000000e+00 11 110200278 110200386 109 - 0.094 0.000 -9.527
ENSG00000137710 E014 1.4854032 0.0092781334 4.514042e-01 5.923595e-01 11 110229441 110229442 2 - 0.257 0.000 -11.630
ENSG00000137710 E015 1.6336964 0.0086685125 9.198709e-01 9.533924e-01 11 110229443 110229446 4 - 0.257 0.364 0.703
ENSG00000137710 E016 2.5215706 0.0058623692 7.368835e-01 8.272076e-01 11 110229447 110229449 3 - 0.360 0.364 0.025
ENSG00000137710 E017 1002.1954646 0.0078448184 1.417572e-32 2.881488e-30 11 110229450 110231549 2100 - 2.637 3.185 1.822
ENSG00000137710 E018 104.6756728 0.0010748850 4.482492e-03 1.449212e-02 11 110231550 110231550 1 - 1.737 1.695 -0.143
ENSG00000137710 E019 291.1569522 0.0003148162 1.593879e-04 7.890965e-04 11 110231551 110231837 287 - 2.172 2.178 0.019
ENSG00000137710 E020 101.7601763 0.0016894151 2.300119e-01 3.624711e-01 11 110231838 110231872 35 - 1.715 1.788 0.248
ENSG00000137710 E021 215.9926185 0.0001876852 5.385859e-03 1.697616e-02 11 110231873 110232004 132 - 2.042 2.071 0.099
ENSG00000137710 E022 138.0707381 0.0002111604 3.952138e-02 9.014432e-02 11 110232005 110232033 29 - 1.849 1.887 0.130
ENSG00000137710 E023 271.0742192 0.0002005349 7.935888e-04 3.236733e-03 11 110233237 110233479 243 - 2.140 2.159 0.065
ENSG00000137710 E024 0.0000000       11 110233480 110233523 44 -      
ENSG00000137710 E025 132.3049347 0.0030042622 4.897166e-02 1.073304e-01 11 110236099 110236191 93 - 1.830 1.858 0.093
ENSG00000137710 E026 0.0000000       11 110236192 110236671 480 -      
ENSG00000137710 E027 187.6857525 0.0002351145 1.485659e-03 5.590054e-03 11 110237492 110237652 161 - 1.983 1.980 -0.009
ENSG00000137710 E028 0.2903454 0.3035216400 9.617105e-01   11 110237653 110237786 134 - 0.065 0.000 -9.143
ENSG00000137710 E029 0.2924217 0.0271727482 1.000000e+00   11 110237787 110237886 100 - 0.065 0.000 -9.454
ENSG00000137710 E030 191.4441433 0.0051157739 4.814560e-03 1.541471e-02 11 110247703 110247833 131 - 1.993 1.974 -0.063
ENSG00000137710 E031 1.5049830 0.0423895840 8.273132e-01 8.914294e-01 11 110253945 110253945 1 - 0.237 0.364 0.858
ENSG00000137710 E032 190.8743318 0.0060057560 1.707809e-03 6.306316e-03 11 110253946 110254109 164 - 1.993 1.945 -0.162
ENSG00000137710 E033 92.4792886 0.0003130753 7.380365e-02 1.495964e-01 11 110255289 110255305 17 - 1.677 1.707 0.101
ENSG00000137710 E034 122.3292335 0.0204366162 1.030934e-01 1.951882e-01 11 110255306 110255385 80 - 1.799 1.802 0.010
ENSG00000137710 E035 177.9865318 0.0009096972 1.851335e-07 1.785339e-06 11 110257767 110257913 147 - 1.968 1.824 -0.486
ENSG00000137710 E036 93.7864718 0.0018235859 2.980366e-04 1.371539e-03 11 110258106 110258113 8 - 1.693 1.562 -0.445
ENSG00000137710 E037 124.2622297 0.0002599289 1.113041e-04 5.737434e-04 11 110258114 110258156 43 - 1.812 1.718 -0.318
ENSG00000137710 E038 96.9532550 0.0002868368 3.239652e-02 7.662158e-02 11 110258157 110258178 22 - 1.699 1.707 0.026
ENSG00000137710 E039 92.2050110 0.0004079289 1.072335e-01 2.014424e-01 11 110258179 110258189 11 - 1.675 1.718 0.144
ENSG00000137710 E040 0.1451727 0.0427192103 5.194118e-01   11 110258190 110258208 19 - 0.034 0.000 -8.482
ENSG00000137710 E041 0.1451727 0.0427192103 5.194118e-01   11 110263332 110263435 104 - 0.034 0.000 -8.482
ENSG00000137710 E042 118.8679787 0.0002415885 1.317377e-03 5.035169e-03 11 110263960 110264020 61 - 1.790 1.739 -0.173
ENSG00000137710 E043 102.7132886 0.0011286642 3.428387e-05 2.009584e-04 11 110264021 110264044 24 - 1.734 1.577 -0.533
ENSG00000137710 E044 193.4261247 0.0005145207 4.675211e-09 6.132416e-08 11 110264045 110264234 190 - 2.006 1.841 -0.555
ENSG00000137710 E045 128.8298428 0.0020904351 2.651240e-05 1.597600e-04 11 110264779 110264874 96 - 1.830 1.695 -0.455
ENSG00000137710 E046 118.3119176 0.0002613104 5.331358e-08 5.713371e-07 11 110272536 110272619 84 - 1.799 1.562 -0.805
ENSG00000137710 E047 0.0000000       11 110272911 110273033 123 -      
ENSG00000137710 E048 0.0000000       11 110273034 110273051 18 -      
ENSG00000137710 E049 73.8988672 0.0005517513 7.745168e-08 8.037351e-07 11 110279681 110279712 32 - 1.604 1.224 -1.314
ENSG00000137710 E050 69.7247339 0.0020267110 2.618362e-06 1.986627e-05 11 110279713 110279756 44 - 1.577 1.257 -1.107
ENSG00000137710 E051 0.2955422 0.0293434024 8.273456e-02   11 110287000 110287207 208 - 0.034 0.364 4.023
ENSG00000137710 E052 0.0000000       11 110288322 110288391 70 -      
ENSG00000137710 E053 0.4502799 0.0330936908 1.000000e+00 1.000000e+00 11 110296029 110296139 111 - 0.094 0.000 -10.047
ENSG00000137710 E054 75.0427268 0.0071492844 2.592936e-06 1.968991e-05 11 110296467 110296712 246 - 1.609 1.257 -1.215