ENSG00000137700

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000330775 ENSG00000137700 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC37A4 protein_coding protein_coding 62.20176 96.28026 50.3556 6.117123 0.2085381 -0.9349512 37.788697 71.354960 23.392479 3.9778040 2.6926785 -1.60855452 0.58064583 0.7424667 0.46410000 -0.27836667 3.831945e-04 4.17802e-29 FALSE TRUE
ENST00000527992 ENSG00000137700 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC37A4 protein_coding processed_transcript 62.20176 96.28026 50.3556 6.117123 0.2085381 -0.9349512 6.501037 0.000000 13.605511 0.0000000 2.6885050 10.41103540 0.12481667 0.0000000 0.27056667 0.27056667 4.178020e-29 4.17802e-29 FALSE TRUE
ENST00000532085 ENSG00000137700 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC37A4 protein_coding retained_intron 62.20176 96.28026 50.3556 6.117123 0.2085381 -0.9349512 3.447205 2.551822 2.610545 0.3823547 0.1932857 0.03269677 0.06174583 0.0262000 0.05183333 0.02563333 1.515936e-03 4.17802e-29 FALSE FALSE
MSTRG.6423.12 ENSG00000137700 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC37A4 protein_coding   62.20176 96.28026 50.3556 6.117123 0.2085381 -0.9349512 6.500663 12.087824 3.785615 2.2886760 0.4439977 -1.67234189 0.09966667 0.1242333 0.07523333 -0.04900000 1.246270e-01 4.17802e-29 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000137700 E001 3.233621 0.0068453369 3.291173e-01 4.726191e-01 11 119024114 119024322 209 - 0.689 0.531 -0.696
ENSG00000137700 E002 1.319136 0.0156385966 7.531275e-02 1.520210e-01 11 119024323 119024350 28 - 0.535 0.219 -1.892
ENSG00000137700 E003 6.665479 0.0077745023 1.508807e-01 2.628653e-01 11 119024351 119024355 5 - 0.689 0.889 0.796
ENSG00000137700 E004 20.929738 0.0039280120 5.085028e-02 1.106884e-01 11 119024356 119024367 12 - 1.165 1.336 0.604
ENSG00000137700 E005 61.057215 0.0019886458 2.265694e-03 8.047943e-03 11 119024368 119024387 20 - 1.616 1.783 0.565
ENSG00000137700 E006 162.282332 0.0009983291 3.302514e-03 1.115621e-02 11 119024388 119024422 35 - 2.088 2.186 0.326
ENSG00000137700 E007 162.062020 0.0008747384 3.819725e-03 1.263573e-02 11 119024423 119024423 1 - 2.090 2.184 0.316
ENSG00000137700 E008 169.206150 0.0002507446 5.339802e-04 2.287053e-03 11 119024424 119024429 6 - 2.100 2.204 0.347
ENSG00000137700 E009 767.802810 0.0042250966 4.887760e-06 3.488177e-05 11 119024430 119024697 268 - 2.718 2.871 0.508
ENSG00000137700 E010 702.817769 0.0010737697 2.029984e-12 4.736137e-11 11 119024698 119024877 180 - 2.681 2.830 0.498
ENSG00000137700 E011 394.604515 0.0004174576 9.781389e-04 3.885055e-03 11 119024878 119024909 32 - 2.494 2.561 0.226
ENSG00000137700 E012 775.385135 0.0001309157 2.997181e-02 7.190342e-02 11 119024910 119025076 167 - 2.815 2.842 0.089
ENSG00000137700 E013 9.695746 0.0018201750 2.157230e-02 5.479395e-02 11 119025152 119025190 39 - 1.150 0.902 -0.912
ENSG00000137700 E014 687.580597 0.0001134865 6.649056e-01 7.726548e-01 11 119025191 119025329 139 - 2.792 2.780 -0.038
ENSG00000137700 E015 38.081376 0.0008968111 3.438308e-04 1.555416e-03 11 119025330 119025691 362 - 1.687 1.471 -0.739
ENSG00000137700 E016 17.305814 0.0034203250 2.717739e-02 6.635405e-02 11 119025692 119025757 66 - 1.340 1.142 -0.698
ENSG00000137700 E017 21.089963 0.0008737582 1.772300e-03 6.511081e-03 11 119025758 119025966 209 - 1.451 1.205 -0.855
ENSG00000137700 E018 563.886705 0.0002749830 2.283981e-01 3.605074e-01 11 119025967 119026080 114 - 2.715 2.690 -0.085
ENSG00000137700 E019 39.998285 0.0009425611 1.859988e-08 2.181988e-07 11 119026081 119026505 425 - 1.770 1.444 -1.109
ENSG00000137700 E020 19.838878 0.0096404948 3.584126e-04 1.612640e-03 11 119026506 119026570 65 - 1.480 1.161 -1.115
ENSG00000137700 E021 16.234077 0.0011591476 2.783544e-03 9.625342e-03 11 119026571 119026602 32 - 1.359 1.099 -0.921
ENSG00000137700 E022 339.936848 0.0001775194 1.760888e-01 2.961234e-01 11 119026603 119026665 63 - 2.504 2.470 -0.113
ENSG00000137700 E023 246.844356 0.0001881322 5.224046e-01 6.562255e-01 11 119026666 119026688 23 - 2.355 2.334 -0.070
ENSG00000137700 E024 23.619799 0.0166430204 2.496808e-04 1.173962e-03 11 119026689 119026936 248 - 1.556 1.210 -1.201
ENSG00000137700 E025 248.253781 0.0001995461 5.565059e-01 6.851336e-01 11 119026937 119026953 17 - 2.356 2.336 -0.066
ENSG00000137700 E026 595.391179 0.0011125958 8.382194e-01 8.988456e-01 11 119026954 119027095 142 - 2.720 2.723 0.008
ENSG00000137700 E027 574.476377 0.0005833296 6.936375e-02 1.423068e-01 11 119027628 119027770 143 - 2.681 2.714 0.108
ENSG00000137700 E028 327.054724 0.0002733189 2.497096e-03 8.754993e-03 11 119027771 119027811 41 - 2.413 2.478 0.216
ENSG00000137700 E029 383.177419 0.0002120769 1.165807e-02 3.271882e-02 11 119027812 119027872 61 - 2.492 2.540 0.160
ENSG00000137700 E030 44.822483 0.0053524982 8.584966e-07 7.233249e-06 11 119027873 119028193 321 - 1.807 1.493 -1.070
ENSG00000137700 E031 329.489097 0.0008426277 2.268193e-01 3.585933e-01 11 119028194 119028240 47 - 2.443 2.470 0.091
ENSG00000137700 E032 672.965757 0.0005620073 4.476136e-01 5.889928e-01 11 119028241 119028426 186 - 2.786 2.769 -0.058
ENSG00000137700 E033 21.065406 0.0161685386 4.318707e-05 2.470607e-04 11 119028427 119028734 308 - 1.532 1.140 -1.368
ENSG00000137700 E034 17.354999 0.0112266136 5.396954e-04 2.308765e-03 11 119028735 119028834 100 - 1.420 1.087 -1.172
ENSG00000137700 E035 36.598105 0.0322632972 1.950351e-03 7.072760e-03 11 119028835 119029221 387 - 1.729 1.406 -1.101
ENSG00000137700 E036 704.960181 0.0015697451 2.892244e-02 6.984944e-02 11 119029222 119029391 170 - 2.832 2.780 -0.173
ENSG00000137700 E037 658.802600 0.0034642264 2.344128e-04 1.110248e-03 11 119029392 119029564 173 - 2.845 2.733 -0.375
ENSG00000137700 E038 51.842681 0.0163191472 7.068376e-08 7.387634e-07 11 119029565 119029866 302 - 1.928 1.506 -1.429
ENSG00000137700 E039 21.309434 0.0289467770 1.022818e-05 6.783232e-05 11 119029867 119029915 49 - 1.585 1.099 -1.699
ENSG00000137700 E040 40.652914 0.0120049521 2.726247e-08 3.094172e-07 11 119029916 119030169 254 - 1.827 1.403 -1.444
ENSG00000137700 E041 35.996469 0.0150796192 2.413960e-02 6.010060e-02 11 119030170 119030231 62 - 1.646 1.454 -0.655
ENSG00000137700 E042 89.402873 0.0080128492 9.389707e-01 9.656756e-01 11 119030232 119030547 316 - 1.907 1.899 -0.026
ENSG00000137700 E043 68.275365 0.0194495688 8.520063e-01 9.082573e-01 11 119030548 119030735 188 - 1.769 1.792 0.075
ENSG00000137700 E044 43.105910 0.0149443318 5.588740e-01 6.870535e-01 11 119030736 119030848 113 - 1.621 1.575 -0.157
ENSG00000137700 E045 245.419560 0.0076201488 4.589200e-07 4.088840e-06 11 119030849 119030926 78 - 2.497 2.259 -0.796