ENSG00000137691

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000434758 ENSG00000137691 HEK293_OSMI2_2hA HEK293_TMG_2hB CFAP300 protein_coding protein_coding 0.7395418 0.5655273 1.231734 0.1252751 0.2202763 1.1094 0.14915342 0.15978006 0.1919652 0.05721926 0.07645427 0.2504398 0.2759917 0.3120000 0.1948 -0.1172000 0.676426451 0.009128114 FALSE TRUE
ENST00000526781 ENSG00000137691 HEK293_OSMI2_2hA HEK293_TMG_2hB CFAP300 protein_coding protein_coding 0.7395418 0.5655273 1.231734 0.1252751 0.2202763 1.1094 0.38304944 0.07063056 0.8765032 0.07063056 0.20482166 3.4587272 0.4255292 0.0957000 0.6940 0.5983000 0.009128114 0.009128114 FALSE TRUE
ENST00000530659 ENSG00000137691 HEK293_OSMI2_2hA HEK293_TMG_2hB CFAP300 protein_coding retained_intron 0.7395418 0.5655273 1.231734 0.1252751 0.2202763 1.1094 0.11654253 0.18595925 0.1632660 0.10575597 0.09246014 -0.1775654 0.1835875 0.3902333 0.1112 -0.2790333 0.626482305 0.009128114 FALSE TRUE
ENST00000534360 ENSG00000137691 HEK293_OSMI2_2hA HEK293_TMG_2hB CFAP300 protein_coding protein_coding 0.7395418 0.5655273 1.231734 0.1252751 0.2202763 1.1094 0.09079642 0.14915745 0.0000000 0.14915745 0.00000000 -3.9923828 0.1148917 0.2020667 0.0000 -0.2020667 0.647933369 0.009128114 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000137691 E001 1.9102209 0.008226645 0.801678590 0.87362150 11 102047437 102047454 18 + 0.443 0.490 0.240
ENSG00000137691 E002 2.5014071 0.006451638 0.563792277 0.69122038 11 102047455 102047457 3 + 0.578 0.490 -0.412
ENSG00000137691 E003 3.7213552 0.004846551 0.350205935 0.49440331 11 102047458 102047467 10 + 0.724 0.594 -0.555
ENSG00000137691 E004 8.3045553 0.002410563 0.727945535 0.82048976 11 102047468 102047580 113 + 0.947 0.991 0.163
ENSG00000137691 E005 0.7748771 0.016581842 0.004024461 0.01321012 11 102047581 102047814 234 + 0.000 0.489 12.063
ENSG00000137691 E006 8.4215256 0.002272649 0.269226494 0.40772449 11 102047815 102047896 82 + 0.921 1.043 0.451
ENSG00000137691 E007 5.5439263 0.003220097 0.941510058 0.96722208 11 102058880 102058955 76 + 0.817 0.836 0.071
ENSG00000137691 E008 4.1777743 0.004908735 0.786149476 0.86303884 11 102066485 102066541 57 + 0.703 0.748 0.182
ENSG00000137691 E009 5.3579686 0.003816358 0.886771212 0.93158332 11 102066542 102066651 110 + 0.817 0.808 -0.036
ENSG00000137691 E010 7.1936560 0.028824856 0.496013605 0.63274901 11 102075873 102076045 173 + 0.947 0.881 -0.250
ENSG00000137691 E011 0.0000000       11 102076046 102076111 66 +      
ENSG00000137691 E012 4.8089168 0.003676940 0.270514299 0.40917756 11 102081215 102081281 67 + 0.817 0.678 -0.565
ENSG00000137691 E013 0.7373885 0.697848394 0.634018268 0.74859527 11 102081282 102081435 154 + 0.178 0.279 0.831
ENSG00000137691 E014 5.3433205 0.003791946 0.877961424 0.92563391 11 102083071 102083419 349 + 0.817 0.808 -0.036
ENSG00000137691 E015 0.2903454 0.555684118 0.561067830   11 102083420 102084554 1135 + 0.177 0.000 -9.563