ENSG00000137642

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000260197 ENSG00000137642 HEK293_OSMI2_2hA HEK293_TMG_2hB SORL1 protein_coding protein_coding 1.729129 1.722329 1.719413 0.1593112 0.1572434 -0.002430325 1.2256969 0.6663687 1.4463007 0.06757247 0.02166592 1.106427 0.7086708 0.3916 0.8548 0.4632 0.002948557 0.002948557 FALSE TRUE
ENST00000530365 ENSG00000137642 HEK293_OSMI2_2hA HEK293_TMG_2hB SORL1 protein_coding retained_intron 1.729129 1.722329 1.719413 0.1593112 0.1572434 -0.002430325 0.3981392 0.9373030 0.1771744 0.17451343 0.13854468 -2.339443 0.2321583 0.5368 0.0912 -0.4456 0.006230200 0.002948557   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000137642 E001 1.8583638 0.0085467744 2.290706e-02 5.754697e-02 11 121452314 121452379 66 + 0.554 0.162 -2.517
ENSG00000137642 E002 4.8229360 0.1277375374 2.691984e-01 4.076906e-01 11 121452380 121452616 237 + 0.807 0.627 -0.742
ENSG00000137642 E003 4.3275161 0.0037915458 4.180764e-01 5.613711e-01 11 121470007 121470123 117 + 0.737 0.664 -0.305
ENSG00000137642 E004 5.9538256 0.0027536311 3.395560e-02 7.966694e-02 11 121478118 121478243 126 + 0.905 0.664 -0.965
ENSG00000137642 E005 5.8271900 0.0029122212 1.261637e-02 3.500539e-02 11 121488032 121488193 162 + 0.918 0.619 -1.205
ENSG00000137642 E006 4.2041028 0.0037843581 9.909630e-02 1.890946e-01 11 121490043 121490110 68 + 0.773 0.569 -0.865
ENSG00000137642 E007 5.8654193 0.0898764204 1.590422e-01 2.738425e-01 11 121496869 121497049 181 + 0.904 0.665 -0.951
ENSG00000137642 E008 3.7610855 0.0164495419 2.613965e-02 6.422679e-02 11 121513003 121513104 102 + 0.773 0.447 -1.452
ENSG00000137642 E009 5.8366507 0.0029210284 3.476573e-01 4.918461e-01 11 121514152 121514321 170 + 0.852 0.775 -0.299
ENSG00000137642 E010 7.5821296 0.0023568740 8.713375e-01 9.212496e-01 11 121520657 121520849 193 + 0.893 0.960 0.254
ENSG00000137642 E011 7.0503935 0.0023720545 9.157562e-01 9.507222e-01 11 121522586 121522703 118 + 0.879 0.915 0.135
ENSG00000137642 E012 5.0501573 0.0032153976 2.869059e-01 4.273536e-01 11 121522916 121522989 74 + 0.806 0.704 -0.411
ENSG00000137642 E013 7.0325389 0.0751328831 5.183769e-01 6.526157e-01 11 121532464 121532552 89 + 0.918 0.863 -0.209
ENSG00000137642 E014 8.3942987 0.0025026370 1.501261e-01 2.618485e-01 11 121543548 121543726 179 + 1.007 0.890 -0.437
ENSG00000137642 E015 9.4705752 0.0026113613 6.525950e-03 1.999000e-02 11 121545243 121545429 187 + 1.097 0.836 -0.973
ENSG00000137642 E016 0.0000000       11 121546863 121547024 162 +      
ENSG00000137642 E017 7.2335128 0.0410427160 1.714459e-01 2.900794e-01 11 121549960 121550088 129 + 0.966 0.804 -0.617
ENSG00000137642 E018 6.0030704 0.1117296710 1.163211e-01 2.147113e-01 11 121550585 121550670 86 + 0.919 0.662 -1.023
ENSG00000137642 E019 7.2027307 0.0868807335 1.514990e-01 2.637104e-01 11 121553937 121554109 173 + 0.976 0.772 -0.785
ENSG00000137642 E020 0.0000000       11 121555042 121555186 145 +      
ENSG00000137642 E021 7.1365737 0.0308378252 1.434373e-01 2.526969e-01 11 121555187 121555318 132 + 0.964 0.804 -0.612
ENSG00000137642 E022 0.0000000       11 121557015 121557313 299 +      
ENSG00000137642 E023 6.4713792 0.0068609603 7.436611e-02 1.505239e-01 11 121557314 121557405 92 + 0.930 0.741 -0.736
ENSG00000137642 E024 10.2130328 0.0016813780 1.820161e-01 3.037456e-01 11 121558591 121558837 247 + 1.072 0.981 -0.334
ENSG00000137642 E025 7.8147658 0.0021446067 4.489122e-01 5.901195e-01 11 121559519 121559657 139 + 0.953 0.915 -0.146
ENSG00000137642 E026 0.0000000       11 121566725 121566843 119 +      
ENSG00000137642 E027 10.4424737 0.0318272421 1.676027e-01 2.850741e-01 11 121566940 121567113 174 + 1.098 0.959 -0.509
ENSG00000137642 E028 8.0348321 0.0309568239 7.389932e-02 1.497455e-01 11 121570157 121570270 114 + 1.017 0.806 -0.800
ENSG00000137642 E029 7.4249715 0.0254915200 3.554186e-02 8.269327e-02 11 121574241 121574363 123 + 0.997 0.741 -0.988
ENSG00000137642 E030 0.0000000       11 121576760 121576837 78 +      
ENSG00000137642 E031 0.0000000       11 121576838 121577038 201 +      
ENSG00000137642 E032 0.0000000       11 121577039 121577138 100 +      
ENSG00000137642 E033 6.5825996 0.0025733575 2.451738e-01 3.802406e-01 11 121577281 121577400 120 + 0.905 0.807 -0.380
ENSG00000137642 E034 5.6110539 0.0028795393 5.660258e-02 1.207607e-01 11 121583458 121583583 126 + 0.879 0.664 -0.865
ENSG00000137642 E035 3.6998895 0.0042672709 1.260551e-03 4.845149e-03 11 121586222 121586329 108 + 0.790 0.279 -2.517
ENSG00000137642 E036 5.8660241 0.0032232544 1.007759e-01 1.916398e-01 11 121588020 121588151 132 + 0.879 0.704 -0.695
ENSG00000137642 E037 7.4763241 0.0022604449 7.557420e-02 1.524301e-01 11 121589259 121589390 132 + 0.976 0.807 -0.643
ENSG00000137642 E038 7.4804505 0.0274701463 1.294847e-01 2.334408e-01 11 121590040 121590174 135 + 0.975 0.807 -0.641
ENSG00000137642 E039 0.0000000       11 121590419 121590897 479 +      
ENSG00000137642 E040 7.6960612 0.0022946668 9.123691e-03 2.659367e-02 11 121591001 121591156 156 + 1.017 0.741 -1.058
ENSG00000137642 E041 8.3366774 0.0046336080 2.772558e-02 6.747244e-02 11 121595623 121595772 150 + 1.026 0.807 -0.830
ENSG00000137642 E042 6.8867632 0.0029103709 8.979442e-02 1.748152e-01 11 121604193 121604324 132 + 0.942 0.775 -0.643
ENSG00000137642 E043 7.4042005 0.0036355873 6.625276e-01 7.708135e-01 11 121605113 121605239 127 + 0.918 0.915 -0.013
ENSG00000137642 E044 10.4707654 0.0017837643 6.380070e-01 7.517654e-01 11 121605402 121605571 170 + 1.007 1.105 0.357
ENSG00000137642 E045 8.6522719 0.0019997666 5.905485e-01 7.133871e-01 11 121606845 121606957 113 + 0.930 1.038 0.401
ENSG00000137642 E046 8.9347064 0.0021734537 5.499247e-01 6.796061e-01 11 121607186 121607290 105 + 0.997 0.981 -0.059
ENSG00000137642 E047 6.2475189 0.0214800881 7.785406e-02 1.560334e-01 11 121608104 121608176 73 + 0.918 0.705 -0.841
ENSG00000137642 E048 1.3703177 0.0871933433 8.279308e-01 8.918311e-01 11 121608200 121611075 2876 + 0.382 0.370 -0.072
ENSG00000137642 E049 8.1694949 0.0362013891 1.498568e-01 2.614896e-01 11 121611076 121611158 83 + 1.007 0.838 -0.639
ENSG00000137642 E050 0.6330284 0.0201387287 6.071629e-01 7.272067e-01 11 121611252 121612735 1484 + 0.167 0.279 0.940
ENSG00000137642 E051 11.1718799 0.0019051315 4.066231e-01 5.502513e-01 11 121612736 121612832 97 + 1.089 1.056 -0.120
ENSG00000137642 E052 0.0000000       11 121614286 121614870 585 +      
ENSG00000137642 E053 12.6385294 0.0014082289 6.884083e-01 7.905599e-01 11 121614871 121615055 185 + 1.121 1.134 0.048
ENSG00000137642 E054 10.0860178 0.0297275183 3.738409e-01 5.182616e-01 11 121618774 121618893 120 + 1.054 0.984 -0.259
ENSG00000137642 E055 11.3642716 0.0072545144 5.845239e-02 1.239812e-01 11 121619753 121619917 165 + 1.136 0.981 -0.565
ENSG00000137642 E056 9.3262147 0.0028660944 9.845290e-01 9.943903e-01 11 121621064 121621238 175 + 0.986 1.038 0.191
ENSG00000137642 E057 0.0000000       11 121621239 121621240 2 +      
ENSG00000137642 E058 6.2615832 0.0027895663 8.747064e-01 9.234613e-01 11 121622162 121622268 107 + 0.837 0.864 0.106
ENSG00000137642 E059 0.0000000       11 121622269 121622269 1 +      
ENSG00000137642 E060 10.7612217 0.0064509944 3.364892e-01 4.803327e-01 11 121625085 121625277 193 + 0.986 1.136 0.544
ENSG00000137642 E061 0.1472490 0.0424154735 8.059490e-01   11 121626201 121627554 1354 + 0.092 0.000 -8.759
ENSG00000137642 E062 10.1408922 0.0018609803 3.043279e-01 4.463421e-01 11 121627555 121627767 213 + 0.965 1.120 0.568
ENSG00000137642 E063 0.8856842 0.0641373884 4.495907e-02 1.001218e-01 11 121628836 121629495 660 + 0.382 0.000 -10.977
ENSG00000137642 E064 8.3370335 0.0021229194 2.494191e-01 3.852439e-01 11 121629496 121629593 98 + 0.879 1.056 0.658
ENSG00000137642 E065 81.7511718 0.0005093997 1.123030e-05 7.374771e-05 11 121629594 121632015 2422 + 1.815 2.031 0.725
ENSG00000137642 E066 102.1308798 0.0221675204 1.580111e-09 2.258640e-08 11 121632016 121633763 1748 + 1.764 2.228 1.560