ENSG00000137601

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000510533 ENSG00000137601 HEK293_OSMI2_2hA HEK293_TMG_2hB NEK1 protein_coding protein_coding 6.915488 2.061245 12.22433 0.3494288 0.3996897 2.562365 3.2346733 0.95787510 6.2788368 0.14579558 0.5127345 2.699900 0.44247500 0.4964333 0.5129000 0.01646667 9.823285e-01 2.931907e-07 FALSE TRUE
ENST00000511633 ENSG00000137601 HEK293_OSMI2_2hA HEK293_TMG_2hB NEK1 protein_coding protein_coding 6.915488 2.061245 12.22433 0.3494288 0.3996897 2.562365 1.5037605 0.04310332 2.5252429 0.04310332 0.1824144 5.577178 0.17850833 0.0277000 0.2072000 0.17950000 8.140801e-03 2.931907e-07 FALSE TRUE
ENST00000638824 ENSG00000137601 HEK293_OSMI2_2hA HEK293_TMG_2hB NEK1 protein_coding processed_transcript 6.915488 2.061245 12.22433 0.3494288 0.3996897 2.562365 0.2103428 0.62996507 0.0000000 0.31675749 0.0000000 -5.999921 0.10485417 0.2783667 0.0000000 -0.27836667 2.653958e-02 2.931907e-07 FALSE TRUE
MSTRG.25721.15 ENSG00000137601 HEK293_OSMI2_2hA HEK293_TMG_2hB NEK1 protein_coding   6.915488 2.061245 12.22433 0.3494288 0.3996897 2.562365 0.5001932 0.13879838 0.4095113 0.13879838 0.4095113 1.495351 0.05773750 0.0508000 0.0351000 -0.01570000 8.081260e-01 2.931907e-07 FALSE TRUE
MSTRG.25721.17 ENSG00000137601 HEK293_OSMI2_2hA HEK293_TMG_2hB NEK1 protein_coding   6.915488 2.061245 12.22433 0.3494288 0.3996897 2.562365 0.5042079 0.00000000 1.9305097 0.00000000 0.3301983 7.600292 0.04124167 0.0000000 0.1565667 0.15656667 2.931907e-07 2.931907e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000137601 E001 0.9599055 0.0310806036 3.661891e-02 8.474644e-02 4 169369704 169369804 101 - 0.137 0.553 2.794
ENSG00000137601 E002 0.0000000       4 169392809 169392856 48 -      
ENSG00000137601 E003 0.7394768 0.0177034427 1.316712e-04 6.662404e-04 4 169392857 169393274 418 - 0.000 0.647 16.828
ENSG00000137601 E004 1.4079796 0.0186854615 1.124782e-04 5.792758e-04 4 169393275 169393280 6 - 0.096 0.789 4.381
ENSG00000137601 E005 6.1101417 0.1839481014 5.066232e-03 1.611076e-02 4 169393281 169393389 109 - 0.509 1.258 2.944
ENSG00000137601 E006 147.0261737 0.0237891162 3.210732e-06 2.386657e-05 4 169393390 169394124 735 - 1.935 2.337 1.348
ENSG00000137601 E007 42.0714779 0.0005791632 2.986177e-06 2.235438e-05 4 169394125 169394227 103 - 1.416 1.754 1.153
ENSG00000137601 E008 21.3192718 0.0008813615 2.239617e-05 1.372881e-04 4 169394228 169394238 11 - 1.113 1.515 1.406
ENSG00000137601 E009 56.3018608 0.0006402550 4.782402e-09 6.263908e-08 4 169394239 169394523 285 - 1.530 1.893 1.233
ENSG00000137601 E010 39.1475700 0.0045961551 1.172265e-01 2.159891e-01 4 169400225 169400357 133 - 1.430 1.589 0.542
ENSG00000137601 E011 59.1571206 0.0040541138 2.951203e-01 4.362420e-01 4 169400521 169400651 131 - 1.613 1.721 0.366
ENSG00000137601 E012 75.5831621 0.0003414391 6.924978e-01 7.937318e-01 4 169401652 169401860 209 - 1.732 1.747 0.051
ENSG00000137601 E013 62.0097953 0.0040923859 9.578178e-01 9.775583e-01 4 169406596 169406747 152 - 1.643 1.685 0.142
ENSG00000137601 E014 77.7724104 0.0051028528 8.450453e-01 9.035977e-01 4 169424553 169424800 248 - 1.742 1.770 0.092
ENSG00000137601 E015 46.6835333 0.0015213241 1.002255e-01 1.908256e-01 4 169426146 169426234 89 - 1.544 1.454 -0.307
ENSG00000137601 E016 56.4818098 0.0004433913 7.276957e-03 2.194450e-02 4 169433545 169433665 121 - 1.633 1.479 -0.526
ENSG00000137601 E017 46.1876347 0.0004993976 2.619966e-01 3.997202e-01 4 169438083 169438259 177 - 1.537 1.491 -0.157
ENSG00000137601 E018 53.9544440 0.0006861949 1.032379e-01 1.954042e-01 4 169463243 169463395 153 - 1.604 1.526 -0.264
ENSG00000137601 E019 65.0622310 0.0004444359 8.217302e-02 1.629483e-01 4 169477124 169477352 229 - 1.681 1.607 -0.250
ENSG00000137601 E020 34.3813765 0.0006323738 3.563252e-03 1.190707e-02 4 169477432 169477497 66 - 1.432 1.193 -0.838
ENSG00000137601 E021 0.4460135 0.0329191946 1.000000e+00 1.000000e+00 4 169477498 169478352 855 - 0.137 0.000 -11.096
ENSG00000137601 E022 0.1515154 0.0423883255 8.748406e-01   4 169478353 169478380 28 - 0.051 0.000 -9.512
ENSG00000137601 E023 0.4418608 0.0241661409 1.000000e+00 1.000000e+00 4 169478381 169479086 706 - 0.137 0.000 -11.096
ENSG00000137601 E024 40.4986924 0.0005524976 2.599256e-01 3.974088e-01 4 169479403 169479534 132 - 1.479 1.427 -0.180
ENSG00000137601 E025 0.0000000       4 169506628 169506734 107 -      
ENSG00000137601 E026 43.1982316 0.0005479705 3.176944e-02 7.540625e-02 4 169507037 169507132 96 - 1.518 1.383 -0.466
ENSG00000137601 E027 42.3407382 0.0005305906 4.751501e-03 1.523702e-02 4 169507715 169507792 78 - 1.517 1.316 -0.692
ENSG00000137601 E028 41.7283949 0.0005107832 1.331555e-01 2.385272e-01 4 169508248 169508331 84 - 1.495 1.413 -0.283
ENSG00000137601 E029 0.0000000       4 169508332 169508768 437 -      
ENSG00000137601 E030 4.3180449 0.0036550561 6.417749e-02 1.336569e-01 4 169508769 169508852 84 - 0.649 0.269 -2.012
ENSG00000137601 E031 0.4502799 0.0330997469 1.000000e+00 1.000000e+00 4 169508853 169509966 1114 - 0.137 0.000 -11.097
ENSG00000137601 E032 44.9061412 0.0005105540 2.805879e-02 6.812933e-02 4 169537809 169537911 103 - 1.534 1.398 -0.468
ENSG00000137601 E033 0.1472490 0.0428777254 8.747251e-01   4 169554043 169554056 14 - 0.051 0.000 -9.511
ENSG00000137601 E034 0.1482932 0.0421570833 5.628694e-02   4 169554057 169554120 64 - 0.000 0.268 14.824
ENSG00000137601 E035 1.1823698 0.0116796527 6.073803e-02 1.278728e-01 4 169554121 169554391 271 - 0.174 0.553 2.382
ENSG00000137601 E036 4.2722453 0.0973186564 8.234566e-03 2.437864e-02 4 169554392 169555719 1328 - 0.475 1.013 2.232
ENSG00000137601 E037 9.0812736 0.0017965828 8.148546e-04 3.312343e-03 4 169555720 169555851 132 - 0.925 0.269 -3.111
ENSG00000137601 E038 53.0819222 0.0004402745 4.074025e-04 1.803088e-03 4 169555932 169556095 164 - 1.617 1.383 -0.803
ENSG00000137601 E039 0.1472490 0.0428777254 8.747251e-01   4 169558402 169558491 90 - 0.051 0.000 -9.511
ENSG00000137601 E040 0.1451727 0.0424514208 8.716874e-01   4 169559076 169559192 117 - 0.051 0.000 -9.511
ENSG00000137601 E041 0.2924217 0.0290785164 1.000000e+00   4 169559193 169559227 35 - 0.096 0.000 -10.511
ENSG00000137601 E042 8.8960231 0.0020505062 1.262358e-01 2.289134e-01 4 169559228 169561154 1927 - 0.817 1.053 0.889
ENSG00000137601 E043 0.1451727 0.0424514208 8.716874e-01   4 169561155 169561479 325 - 0.051 0.000 -9.511
ENSG00000137601 E044 35.0907107 0.0024496335 6.088155e-02 1.281209e-01 4 169561480 169561554 75 - 1.432 1.298 -0.466
ENSG00000137601 E045 26.8021161 0.0150760841 1.200502e-01 2.200575e-01 4 169561687 169561737 51 - 1.320 1.169 -0.529
ENSG00000137601 E046 25.3094493 0.0115582361 2.443857e-01 3.793350e-01 4 169561832 169561887 56 - 1.293 1.193 -0.353
ENSG00000137601 E047 16.1721659 0.0149493410 5.370335e-01 6.686913e-01 4 169561888 169561891 4 - 1.104 1.053 -0.187
ENSG00000137601 E048 25.7402605 0.0130600583 4.386865e-01 5.805606e-01 4 169562137 169562196 60 - 1.293 1.238 -0.192
ENSG00000137601 E049 0.0000000       4 169563236 169563349 114 -      
ENSG00000137601 E050 2.0336237 0.0069379852 1.135181e-01 2.106519e-01 4 169576604 169576927 324 - 0.325 0.646 1.625
ENSG00000137601 E051 40.4510878 0.0015736194 4.628115e-01 6.026700e-01 4 169576928 169577079 152 - 1.455 1.548 0.318
ENSG00000137601 E052 0.1451727 0.0424514208 8.716874e-01   4 169577080 169577245 166 - 0.051 0.000 -9.511
ENSG00000137601 E053 28.4006184 0.0129925017 8.001388e-01 8.725927e-01 4 169580842 169580902 61 - 1.322 1.335 0.044
ENSG00000137601 E054 55.6784684 0.0004362993 4.645310e-01 6.042530e-01 4 169585349 169585549 201 - 1.609 1.598 -0.039
ENSG00000137601 E055 30.8571054 0.0083821687 2.936649e-01 4.347229e-01 4 169587559 169587613 55 - 1.370 1.298 -0.250
ENSG00000137601 E056 35.9092640 0.0006082222 5.562351e-01 6.849305e-01 4 169588649 169588735 87 - 1.424 1.413 -0.040
ENSG00000137601 E057 29.0398012 0.0039763582 4.242838e-01 5.672599e-01 4 169589447 169589514 68 - 1.337 1.299 -0.135
ENSG00000137601 E058 0.0000000       4 169589515 169589541 27 -      
ENSG00000137601 E059 33.9905976 0.0061210903 9.949584e-01 1.000000e+00 4 169590726 169590809 84 - 1.391 1.428 0.129
ENSG00000137601 E060 0.4355181 0.5643148841 1.000000e+00 1.000000e+00 4 169598500 169598599 100 - 0.136 0.000 -11.086
ENSG00000137601 E061 31.8988492 0.0006319200 1.148444e-01 2.126050e-01 4 169599100 169599197 98 - 1.386 1.279 -0.374
ENSG00000137601 E062 43.2574231 0.0178086019 3.754830e-01 5.199167e-01 4 169602008 169602104 97 - 1.506 1.458 -0.166
ENSG00000137601 E063 50.6296426 0.0019599199 1.032035e-01 1.953557e-01 4 169602514 169602662 149 - 1.577 1.492 -0.292
ENSG00000137601 E064 22.4601244 0.0009108939 1.603087e-02 4.280479e-02 4 169602663 169602678 16 - 1.259 1.018 -0.864
ENSG00000137601 E065 0.2987644 0.0295409880 1.000000e+00   4 169610157 169612019 1863 - 0.096 0.000 -10.511
ENSG00000137601 E066 45.9197792 0.0004698971 1.186030e-02 3.319591e-02 4 169612020 169612143 124 - 1.545 1.383 -0.558
ENSG00000137601 E067 8.5507278 0.0019544591 5.186397e-01 6.528770e-01 4 169612144 169612221 78 - 0.856 0.789 -0.263
ENSG00000137601 E068 52.2784709 0.0040022686 2.863836e-03 9.864098e-03 4 169612222 169612632 411 - 1.605 1.399 -0.707