ENSG00000137563

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000260118 ENSG00000137563 HEK293_OSMI2_2hA HEK293_TMG_2hB GGH protein_coding protein_coding 42.91748 18.5933 69.83 3.786088 2.398236 1.908495 15.476782 4.077326 27.5787785 0.3187754 1.4752191 2.754852 0.29748333 0.2317333 0.39733333 0.16560000 0.04361389 0.04361389 FALSE TRUE
ENST00000518466 ENSG00000137563 HEK293_OSMI2_2hA HEK293_TMG_2hB GGH protein_coding processed_transcript 42.91748 18.5933 69.83 3.786088 2.398236 1.908495 23.234060 10.345818 36.7714882 2.6559268 4.5129630 1.828538 0.56185417 0.5458667 0.52330000 -0.02256667 0.90522495 0.04361389 FALSE TRUE
ENST00000677919 ENSG00000137563 HEK293_OSMI2_2hA HEK293_TMG_2hB GGH protein_coding protein_coding 42.91748 18.5933 69.83 3.786088 2.398236 1.908495 1.140903 2.640038 0.9252647 0.8878447 0.5710406 -1.502566 0.04502083 0.1371333 0.01383333 -0.12330000 0.11239577 0.04361389 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000137563 E001 2.6611500 0.0072793981 2.817570e-04 1.305565e-03 8 63014881 63015078 198 - 0.312 0.883 2.658
ENSG00000137563 E002 30.7724909 0.0460140961 4.626145e-04 2.016588e-03 8 63015079 63015153 75 - 1.288 1.737 1.541
ENSG00000137563 E003 95.6073830 0.0030534995 7.477681e-09 9.433471e-08 8 63015154 63015210 57 - 1.851 2.118 0.898
ENSG00000137563 E004 392.4979543 0.0001724993 5.820617e-11 1.068610e-09 8 63015211 63015428 218 - 2.507 2.635 0.424
ENSG00000137563 E005 285.9218882 0.0001676883 6.839286e-03 2.080893e-02 8 63015429 63015453 25 - 2.388 2.450 0.208
ENSG00000137563 E006 15.1329560 0.0019263008 3.509035e-02 8.181778e-02 8 63015454 63017065 1612 - 1.099 1.295 0.696
ENSG00000137563 E007 6.9050093 0.0025519954 1.874673e-01 3.105442e-01 8 63017066 63017183 118 - 0.808 0.976 0.639
ENSG00000137563 E008 2.6464911 0.0565461481 1.227773e-01 2.239252e-01 8 63017184 63017333 150 - 0.439 0.716 1.264
ENSG00000137563 E009 3.6158467 0.0044928543 8.547655e-03 2.515969e-02 8 63017334 63017492 159 - 0.492 0.883 1.660
ENSG00000137563 E010 409.2595066 0.0001828199 2.317535e-01 3.645353e-01 8 63017493 63017630 138 - 2.554 2.576 0.074
ENSG00000137563 E011 1.5425563 0.0110489876 5.174057e-03 1.640161e-02 8 63017631 63017970 340 - 0.183 0.666 2.788
ENSG00000137563 E012 1.1961019 0.1273132556 5.287524e-01 6.616465e-01 8 63022717 63023508 792 - 0.348 0.204 -1.034
ENSG00000137563 E013 19.5413460 0.0009483093 5.699390e-04 2.421304e-03 8 63023509 63023739 231 - 1.171 1.450 0.975
ENSG00000137563 E014 4.5088916 0.0307430940 5.496620e-02 1.179336e-01 8 63023740 63023906 167 - 0.600 0.913 1.273
ENSG00000137563 E015 272.7381108 0.0009159591 5.368885e-01 6.685548e-01 8 63023907 63023939 33 - 2.389 2.370 -0.064
ENSG00000137563 E016 304.0933432 0.0005747531 4.064156e-01 5.500631e-01 8 63023940 63023997 58 - 2.437 2.414 -0.077
ENSG00000137563 E017 3.1848741 0.0052330665 7.856434e-01 8.626578e-01 8 63023998 63024079 82 - 0.560 0.605 0.203
ENSG00000137563 E018 423.0563256 0.0001356792 1.717196e-02 4.532275e-02 8 63024080 63024186 107 - 2.587 2.538 -0.161
ENSG00000137563 E019 473.3224558 0.0001222025 2.031768e-03 7.325386e-03 8 63026158 63026296 139 - 2.637 2.578 -0.196
ENSG00000137563 E020 4.4112667 0.0072489230 5.702137e-01 6.967156e-01 8 63026297 63026999 703 - 0.702 0.605 -0.413
ENSG00000137563 E021 1.3360778 0.0100631977 6.908565e-02 1.418622e-01 8 63027000 63027180 181 - 0.411 0.000 -11.488
ENSG00000137563 E022 232.6564506 0.0001740595 1.263692e-04 6.428989e-04 8 63027181 63027193 13 - 2.340 2.232 -0.360
ENSG00000137563 E023 334.0385324 0.0001517218 3.531885e-02 8.226331e-02 8 63027194 63027265 72 - 2.484 2.436 -0.161
ENSG00000137563 E024 1.1897592 0.0112279321 4.846404e-01 6.226007e-01 8 63027266 63028144 879 - 0.348 0.205 -1.021
ENSG00000137563 E025 0.9286724 0.0162128236 7.585793e-01 8.431394e-01 8 63028145 63030166 2022 - 0.273 0.205 -0.535
ENSG00000137563 E026 233.7252123 0.0001596901 9.514623e-01 9.736334e-01 8 63030167 63030217 51 - 2.318 2.319 0.003
ENSG00000137563 E027 307.2809999 0.0019525623 5.435296e-03 1.711262e-02 8 63035656 63035770 115 - 2.457 2.361 -0.318
ENSG00000137563 E028 0.7415677 0.0303591678 8.258531e-02 1.635895e-01 8 63035771 63035826 56 - 0.130 0.448 2.365
ENSG00000137563 E029 0.5891098 0.0182859829 3.651212e-01 5.094577e-01 8 63035827 63036834 1008 - 0.231 0.000 -10.275
ENSG00000137563 E030 1.9239280 0.0647417288 1.874098e-01 3.104684e-01 8 63038474 63038545 72 - 0.492 0.205 -1.803
ENSG00000137563 E031 215.5378678 0.0067994746 7.951633e-03 2.365598e-02 8 63038660 63039407 748 - 2.313 2.166 -0.493