ENSG00000137547

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000260102 ENSG00000137547 HEK293_OSMI2_2hA HEK293_TMG_2hB MRPL15 protein_coding protein_coding 102.4553 83.07233 137.6331 14.92624 2.134635 0.7283185 8.568115 5.270813 17.576262 2.391888 0.8271046 1.7356168 0.07529583 0.05983333 0.12773333 0.067900000 1.707690e-01 9.532125e-05 FALSE TRUE
ENST00000519831 ENSG00000137547 HEK293_OSMI2_2hA HEK293_TMG_2hB MRPL15 protein_coding protein_coding 102.4553 83.07233 137.6331 14.92624 2.134635 0.7283185 40.666598 29.275314 59.789011 1.777961 1.0673915 1.0299443 0.39304167 0.36706667 0.43480000 0.067733333 5.029175e-01 9.532125e-05 FALSE FALSE
MSTRG.31510.1 ENSG00000137547 HEK293_OSMI2_2hA HEK293_TMG_2hB MRPL15 protein_coding   102.4553 83.07233 137.6331 14.92624 2.134635 0.7283185 5.861915 4.932666 7.856502 1.446105 0.5753252 0.6704327 0.05917083 0.05863333 0.05696667 -0.001666667 1.000000e+00 9.532125e-05 FALSE TRUE
MSTRG.31510.4 ENSG00000137547 HEK293_OSMI2_2hA HEK293_TMG_2hB MRPL15 protein_coding   102.4553 83.07233 137.6331 14.92624 2.134635 0.7283185 15.055270 9.616837 21.241435 3.206512 2.7341673 1.1424265 0.14472917 0.11103333 0.15466667 0.043633333 6.067444e-01 9.532125e-05 FALSE TRUE
MSTRG.31510.5 ENSG00000137547 HEK293_OSMI2_2hA HEK293_TMG_2hB MRPL15 protein_coding   102.4553 83.07233 137.6331 14.92624 2.134635 0.7283185 30.620902 32.708070 27.419011 7.847692 3.3579091 -0.2543851 0.31361667 0.38563333 0.19860000 -0.187033333 9.532125e-05 9.532125e-05 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000137547 E001 1.809070 0.0082332357 0.4241658533 0.5671441164 8 54135205 54135219 15 + 0.519 0.393 -0.648
ENSG00000137547 E002 1.809070 0.0082332357 0.4241658533 0.5671441164 8 54135220 54135220 1 + 0.519 0.393 -0.648
ENSG00000137547 E003 65.487706 0.0091142105 0.7075979622 0.8054687273 8 54135221 54135240 20 + 1.814 1.838 0.079
ENSG00000137547 E004 237.034776 0.0012037630 0.4751338760 0.6138847111 8 54135241 54135276 36 + 2.390 2.379 -0.036
ENSG00000137547 E005 671.794582 0.0018033281 0.6120336152 0.7310622331 8 54135277 54135391 115 + 2.838 2.824 -0.047
ENSG00000137547 E006 1.036167 0.0116888137 0.0888218114 0.1733153023 8 54136508 54136510 3 + 0.436 0.136 -2.232
ENSG00000137547 E007 538.413675 0.0004165714 0.3089216915 0.4511967521 8 54136511 54136538 28 + 2.743 2.734 -0.028
ENSG00000137547 E008 657.308878 0.0006606345 0.9531846381 0.9747114649 8 54136539 54136610 72 + 2.822 2.828 0.019
ENSG00000137547 E009 656.664295 0.0001044510 0.0652218432 0.1354002205 8 54136611 54136665 55 + 2.833 2.821 -0.037
ENSG00000137547 E010 961.185418 0.0005105855 0.2479565579 0.3835170576 8 54137268 54137433 166 + 2.994 2.986 -0.028
ENSG00000137547 E011 751.680335 0.0007956170 0.2846501972 0.4249066225 8 54142663 54142786 124 + 2.870 2.899 0.095
ENSG00000137547 E012 1.558453 0.0137680864 0.1080444890 0.2026370329 8 54142787 54142827 41 + 0.519 0.240 -1.646
ENSG00000137547 E013 1570.917908 0.0019828064 0.0918886668 0.1780544989 8 54147382 54148266 885 + 3.181 3.218 0.125
ENSG00000137547 E014 42.509846 0.0234788761 0.0001056937 0.0005481944 8 54148267 54148514 248 + 1.776 1.435 -1.162
ENSG00000137547 E015 0.965204 0.4085735705 0.7387775511 0.8285765242 8 54150441 54150610 170 + 0.334 0.241 -0.643