ENSG00000137522

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361756 ENSG00000137522 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF121 protein_coding protein_coding 28.1822 36.45854 23.62165 1.09088 0.496984 -0.6259317 19.7242730 25.8706824 14.639627 1.12148195 0.8406689 -0.8210117 0.69994167 0.7109333 0.62093333 -0.09000000 4.523037e-01 8.548197e-05 FALSE  
ENST00000528683 ENSG00000137522 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF121 protein_coding retained_intron 28.1822 36.45854 23.62165 1.09088 0.496984 -0.6259317 0.5425049 0.1749577 1.438753 0.03115645 0.5478196 2.9695448 0.02215833 0.0048000 0.06133333 0.05653333 8.548197e-05 8.548197e-05 FALSE  
ENST00000530137 ENSG00000137522 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF121 protein_coding protein_coding 28.1822 36.45854 23.62165 1.09088 0.496984 -0.6259317 2.7312220 4.8383678 2.019406 0.97673177 1.0451177 -1.2564413 0.08888333 0.1316000 0.08460000 -0.04700000 7.558202e-01 8.548197e-05 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000137522 E001 1.412246 0.2159655241 6.263111e-01 7.422663e-01 11 71929018 71929026 9 + 0.275 0.389 0.712
ENSG00000137522 E002 1.593950 0.0192588917 4.196368e-01 5.628880e-01 11 71929027 71929031 5 + 0.275 0.428 0.930
ENSG00000137522 E003 1.775655 0.0088213980 3.073294e-01 4.495460e-01 11 71929032 71929033 2 + 0.275 0.466 1.122
ENSG00000137522 E004 3.748914 0.0497233780 7.886429e-02 1.576978e-01 11 71929034 71929045 12 + 0.829 0.532 -1.259
ENSG00000137522 E005 3.748914 0.0497233780 7.886429e-02 1.576978e-01 11 71929046 71929046 1 + 0.829 0.532 -1.259
ENSG00000137522 E006 6.631710 0.0315572934 1.756089e-01 2.954764e-01 11 71929047 71929050 4 + 0.973 0.781 -0.735
ENSG00000137522 E007 31.489751 0.0009103863 2.400276e-03 8.462012e-03 11 71929051 71929075 25 + 1.595 1.410 -0.635
ENSG00000137522 E008 37.030411 0.0005988250 4.931424e-03 1.573887e-02 11 71929076 71929081 6 + 1.646 1.488 -0.539
ENSG00000137522 E009 75.320567 0.0003772243 2.786484e-01 4.183098e-01 11 71929082 71929124 43 + 1.876 1.837 -0.132
ENSG00000137522 E010 64.653705 0.0004124385 9.579836e-01 9.776557e-01 11 71957227 71957238 12 + 1.782 1.787 0.016
ENSG00000137522 E011 70.893927 0.0003519957 9.786422e-01 9.907651e-01 11 71957239 71957264 26 + 1.822 1.827 0.020
ENSG00000137522 E012 178.129043 0.0002411605 3.675645e-01 5.119318e-01 11 71960750 71960891 142 + 2.233 2.215 -0.060
ENSG00000137522 E013 5.527314 0.0127809887 8.022414e-03 2.383698e-02 11 71962152 71962289 138 + 0.992 0.640 -1.391
ENSG00000137522 E014 6.522604 0.0024884812 1.052575e-01 1.984842e-01 11 71978086 71978235 150 + 0.972 0.781 -0.735
ENSG00000137522 E015 131.247429 0.0002417756 3.422625e-01 4.862583e-01 11 71982761 71982806 46 + 2.106 2.083 -0.078
ENSG00000137522 E016 204.343679 0.0002364703 1.127126e-01 2.095021e-01 11 71982807 71982915 109 + 2.301 2.267 -0.114
ENSG00000137522 E017 1.760807 0.0179588751 9.133245e-01 9.490685e-01 11 71982916 71983170 255 + 0.442 0.428 -0.074
ENSG00000137522 E018 1.398430 0.0099821274 2.112606e-01 3.399879e-01 11 71983657 71983770 114 + 0.506 0.292 -1.202
ENSG00000137522 E019 226.151489 0.0052582920 8.068476e-01 8.773200e-01 11 71987004 71987111 108 + 2.312 2.328 0.054
ENSG00000137522 E020 278.866458 0.0026673285 1.080675e-01 2.026675e-01 11 71990597 71990717 121 + 2.444 2.400 -0.148
ENSG00000137522 E021 4.572913 0.0036211527 6.825081e-09 8.679540e-08 11 71990718 71990796 79 + 1.096 0.292 -3.579
ENSG00000137522 E022 341.392505 0.0001638935 8.949880e-01 9.368903e-01 11 71994719 71994852 134 + 2.499 2.503 0.015
ENSG00000137522 E023 5.817569 0.0028671679 6.656739e-02 1.376686e-01 11 71995246 71995439 194 + 0.951 0.726 -0.879
ENSG00000137522 E024 6.150662 0.0027161385 5.951995e-02 1.258019e-01 11 71995440 71995449 10 + 0.972 0.745 -0.879
ENSG00000137522 E025 268.951540 0.0004205873 4.130809e-01 5.566164e-01 11 71995450 71995551 102 + 2.379 2.405 0.087
ENSG00000137522 E026 1057.293730 0.0006593644 8.593471e-06 5.797747e-05 11 71996195 71997597 1403 + 2.948 3.011 0.210