ENSG00000137513

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000281038 ENSG00000137513 HEK293_OSMI2_2hA HEK293_TMG_2hB NARS2 protein_coding protein_coding 21.29258 12.53224 29.21007 1.792059 1.351147 1.220165 0.6182383 1.3645200 0.5207406 0.2825470 0.52074058 -1.3728491 0.03885833 0.11496667 0.01920000 -0.09576667 9.227972e-02 3.079073e-22 FALSE  
ENST00000525345 ENSG00000137513 HEK293_OSMI2_2hA HEK293_TMG_2hB NARS2 protein_coding processed_transcript 21.29258 12.53224 29.21007 1.792059 1.351147 1.220165 2.0706445 1.6143223 2.2614920 0.5422399 1.03888645 0.4838023 0.09506250 0.12380000 0.07450000 -0.04930000 5.615935e-01 3.079073e-22 FALSE  
ENST00000695347 ENSG00000137513 HEK293_OSMI2_2hA HEK293_TMG_2hB NARS2 protein_coding nonsense_mediated_decay 21.29258 12.53224 29.21007 1.792059 1.351147 1.220165 2.3763825 2.5481886 3.4385842 0.4176181 0.67872613 0.4308816 0.11940417 0.21383333 0.11666667 -0.09716667 2.947484e-01 3.079073e-22 FALSE  
ENST00000695349 ENSG00000137513 HEK293_OSMI2_2hA HEK293_TMG_2hB NARS2 protein_coding nonsense_mediated_decay 21.29258 12.53224 29.21007 1.792059 1.351147 1.220165 0.7071849 1.1219232 0.5053344 0.1643359 0.13209222 -1.1351954 0.05123750 0.09243333 0.01703333 -0.07540000 3.834320e-05 3.079073e-22 TRUE  
ENST00000695350 ENSG00000137513 HEK293_OSMI2_2hA HEK293_TMG_2hB NARS2 protein_coding nonsense_mediated_decay 21.29258 12.53224 29.21007 1.792059 1.351147 1.220165 3.7983047 1.8370296 4.8993563 0.5754005 0.03218443 1.4103269 0.17050417 0.14056667 0.16833333 0.02776667 7.057632e-01 3.079073e-22 TRUE  
ENST00000695355 ENSG00000137513 HEK293_OSMI2_2hA HEK293_TMG_2hB NARS2 protein_coding nonsense_mediated_decay 21.29258 12.53224 29.21007 1.792059 1.351147 1.220165 3.5106347 0.9060128 4.6817140 0.5774269 0.74749052 2.3566755 0.16192500 0.07640000 0.15880000 0.08240000 4.802411e-01 3.079073e-22 TRUE  
MSTRG.6082.30 ENSG00000137513 HEK293_OSMI2_2hA HEK293_TMG_2hB NARS2 protein_coding   21.29258 12.53224 29.21007 1.792059 1.351147 1.220165 2.1175233 0.0000000 2.9122672 0.0000000 0.28441038 8.1909443 0.07640417 0.00000000 0.09930000 0.09930000 3.079073e-22 3.079073e-22 FALSE  
MSTRG.6082.31 ENSG00000137513 HEK293_OSMI2_2hA HEK293_TMG_2hB NARS2 protein_coding   21.29258 12.53224 29.21007 1.792059 1.351147 1.220165 2.3784069 0.4158458 4.1375030 0.4158458 0.36833685 3.2838400 0.09380417 0.02580000 0.14126667 0.11546667 9.799009e-02 3.079073e-22 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000137513 E001 0.0000000       11 78435620 78435967 348 -      
ENSG00000137513 E002 0.1482932 0.0411597534 2.882262e-01   11 78435968 78435975 8 - 0.000 0.153 10.461
ENSG00000137513 E003 0.1482932 0.0411597534 2.882262e-01   11 78435976 78436006 31 - 0.000 0.153 12.747
ENSG00000137513 E004 0.1482932 0.0411597534 2.882262e-01   11 78436007 78436008 2 - 0.000 0.153 12.747
ENSG00000137513 E005 0.1482932 0.0411597534 2.882262e-01   11 78436009 78436009 1 - 0.000 0.153 12.747
ENSG00000137513 E006 0.6997360 0.0166973602 9.593043e-03 2.776311e-02 11 78436010 78436022 13 - 0.000 0.431 14.897
ENSG00000137513 E007 0.6997360 0.0166973602 9.593043e-03 2.776311e-02 11 78436023 78436032 10 - 0.000 0.431 14.897
ENSG00000137513 E008 5.8755512 0.0166511559 8.306797e-06 5.622357e-05 11 78436033 78436047 15 - 0.476 1.094 2.517
ENSG00000137513 E009 6.3476010 0.0388834834 1.356007e-04 6.838951e-04 11 78436048 78436075 28 - 0.543 1.108 2.245
ENSG00000137513 E010 38.7958208 0.0034077818 2.338992e-02 5.855578e-02 11 78436076 78436215 140 - 1.540 1.680 0.475
ENSG00000137513 E011 34.4492071 0.0010346226 1.625850e-01 2.785200e-01 11 78436216 78436222 7 - 1.514 1.597 0.283
ENSG00000137513 E012 42.0790462 0.0014842898 3.252857e-01 4.687264e-01 11 78436223 78436257 35 - 1.612 1.666 0.183
ENSG00000137513 E013 49.7146626 0.0004674086 3.838184e-01 5.280287e-01 11 78436258 78436278 21 - 1.689 1.732 0.145
ENSG00000137513 E014 59.2368747 0.0005350454 2.569215e-01 3.939444e-01 11 78436279 78436303 25 - 1.761 1.813 0.176
ENSG00000137513 E015 63.7003012 0.0003857231 4.729360e-01 6.119562e-01 11 78436304 78436321 18 - 1.799 1.830 0.105
ENSG00000137513 E016 60.2130621 0.0003942332 2.517935e-01 3.880728e-01 11 78436322 78436324 3 - 1.765 1.816 0.174
ENSG00000137513 E017 235.5277047 0.0002314265 4.087966e-03 1.338865e-02 11 78436325 78436669 345 - 2.344 2.409 0.217
ENSG00000137513 E018 95.2196589 0.0003428299 3.680680e-01 5.124711e-01 11 78436670 78436703 34 - 1.969 2.001 0.108
ENSG00000137513 E019 155.2504911 0.0002433550 1.719917e-01 2.907926e-01 11 78436704 78436814 111 - 2.178 2.216 0.128
ENSG00000137513 E020 1.1018559 0.0136520135 2.880044e-01 4.285457e-01 11 78436815 78436842 28 - 0.243 0.431 1.179
ENSG00000137513 E021 2.2195945 0.0064516380 9.238239e-01 9.560302e-01 11 78436843 78437967 1125 - 0.511 0.494 -0.082
ENSG00000137513 E022 86.3612312 0.0003230181 3.946790e-01 5.385148e-01 11 78441091 78441117 27 - 1.929 1.961 0.107
ENSG00000137513 E023 1.8789983 0.0138463987 2.415301e-01 3.759831e-01 11 78441118 78441382 265 - 0.352 0.550 1.031
ENSG00000137513 E024 0.9026481 0.6343434097 1.000000e+00 1.000000e+00 11 78441383 78441707 325 - 0.303 0.257 -0.325
ENSG00000137513 E025 1.8027258 0.0088595222 5.657873e-01 6.928413e-01 11 78441708 78443660 1953 - 0.397 0.495 0.504
ENSG00000137513 E026 151.8458326 0.0002443001 1.406036e-01 2.488526e-01 11 78443661 78443758 98 - 2.166 2.207 0.139
ENSG00000137513 E027 3.1064366 0.0048276554 5.169819e-01 6.514742e-01 11 78453970 78454045 76 - 0.653 0.550 -0.457
ENSG00000137513 E028 1.6628506 0.0086124111 1.462815e-01 2.566290e-01 11 78455783 78457331 1549 - 0.301 0.550 1.351
ENSG00000137513 E029 1.2639554 0.0102749084 4.750130e-01 6.137839e-01 11 78457332 78457406 75 - 0.398 0.267 -0.819
ENSG00000137513 E030 83.5406539 0.0059104686 6.076061e-01 7.275305e-01 11 78465876 78465882 7 - 1.913 1.945 0.106
ENSG00000137513 E031 175.1242801 0.0086619699 9.906869e-01 9.983332e-01 11 78465883 78466013 131 - 2.241 2.244 0.010
ENSG00000137513 E032 0.7384472 0.0266154373 9.021639e-01 9.416653e-01 11 78467412 78467534 123 - 0.243 0.266 0.177
ENSG00000137513 E033 129.8144208 0.0008848133 7.136856e-01 8.100994e-01 11 78469247 78469313 67 - 2.121 2.108 -0.043
ENSG00000137513 E034 0.2966881 0.0271199401 4.038613e-01   11 78475690 78475771 82 - 0.176 0.000 -13.236
ENSG00000137513 E035 2.5195935 0.0097455922 3.172317e-02 7.531153e-02 11 78475772 78476978 1207 - 0.653 0.267 -2.040
ENSG00000137513 E036 1.3382679 0.2259231631 3.339872e-02 7.857250e-02 11 78476979 78478437 1459 - 0.512 0.000 -14.849
ENSG00000137513 E037 90.7318074 0.0026069712 7.547709e-01 8.403051e-01 11 78478438 78478470 33 - 1.957 1.968 0.037
ENSG00000137513 E038 78.6328731 0.0022018129 6.592702e-01 7.681232e-01 11 78478471 78478475 5 - 1.909 1.887 -0.075
ENSG00000137513 E039 0.7415677 0.0498111205 3.384079e-01 4.822773e-01 11 78478476 78478584 109 - 0.176 0.355 1.339
ENSG00000137513 E040 139.4738748 0.0007499021 7.470458e-01 8.346588e-01 11 78478585 78478683 99 - 2.142 2.150 0.026
ENSG00000137513 E041 150.2325384 0.0003585042 2.660136e-02 6.516180e-02 11 78493063 78493195 133 - 2.204 2.136 -0.228
ENSG00000137513 E042 0.7300161 0.0564239732 7.510296e-02 1.516977e-01 11 78527380 78528841 1462 - 0.351 0.000 -14.439
ENSG00000137513 E043 109.3351791 0.0003602880 2.425387e-02 6.033595e-02 11 78528842 78528936 95 - 2.072 1.992 -0.269
ENSG00000137513 E044 0.8899506 0.0135272103 3.856946e-02 8.840162e-02 11 78556453 78556538 86 - 0.397 0.000 -14.794
ENSG00000137513 E045 1.9209318 0.0085891001 3.882945e-01 5.323965e-01 11 78557180 78557251 72 - 0.511 0.357 -0.818
ENSG00000137513 E046 112.8406581 0.0003076681 7.121162e-03 2.154017e-02 11 78559539 78559619 81 - 2.091 1.997 -0.314
ENSG00000137513 E047 0.6235652 0.0226228287 6.296764e-01 7.449963e-01 11 78561936 78562027 92 - 0.243 0.154 -0.818
ENSG00000137513 E048 0.0000000       11 78563706 78563822 117 -      
ENSG00000137513 E049 143.6906580 0.0035834334 1.750058e-01 2.946790e-01 11 78566132 78566272 141 - 2.182 2.116 -0.219
ENSG00000137513 E050 0.7749669 0.1520662894 4.920938e-01 6.293039e-01 11 78566273 78568631 2359 - 0.301 0.154 -1.232
ENSG00000137513 E051 117.2698329 0.0018567470 1.494634e-01 2.609377e-01 11 78568632 78568714 83 - 2.093 2.031 -0.207
ENSG00000137513 E052 92.7313245 0.0016143612 3.879635e-03 1.280551e-02 11 78568715 78568752 38 - 2.017 1.894 -0.413
ENSG00000137513 E053 110.8349605 0.0040480473 2.480307e-02 6.147070e-02 11 78571335 78571444 110 - 2.087 1.975 -0.373
ENSG00000137513 E054 1.6941629 0.0080854286 3.617215e-02 8.391752e-02 11 78571445 78571670 226 - 0.543 0.154 -2.555
ENSG00000137513 E055 0.9557277 0.0140763310 2.848823e-01 4.251656e-01 11 78572997 78573133 137 - 0.352 0.154 -1.554
ENSG00000137513 E056 1.2931002 0.0111250690 4.796357e-01 6.180027e-01 11 78573134 78573265 132 - 0.397 0.267 -0.818
ENSG00000137513 E057 2.5474140 0.0060577206 1.253692e-01 2.276706e-01 11 78573266 78573410 145 - 0.439 0.683 1.127
ENSG00000137513 E058 3.2032419 0.0051313177 1.355346e-03 5.160717e-03 11 78573411 78573528 118 - 0.352 0.841 2.251
ENSG00000137513 E059 0.5483223 0.0243580474 2.992580e-01 4.407606e-01 11 78573529 78573530 2 - 0.097 0.267 1.769
ENSG00000137513 E060 159.4352776 0.0070028883 9.464010e-01 9.703568e-01 11 78574348 78574789 442 - 2.205 2.193 -0.040
ENSG00000137513 E061 19.8544658 0.0009323281 9.683691e-01 9.842431e-01 11 78574790 78574828 39 - 1.316 1.312 -0.014
ENSG00000137513 E062 6.4783162 0.0025978825 1.266694e-02 3.512668e-02 11 78574829 78575194 366 - 0.977 0.643 -1.322