ENSG00000137509

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000393399 ENSG00000137509 HEK293_OSMI2_2hA HEK293_TMG_2hB PRCP protein_coding protein_coding 73.72512 70.46929 74.81766 8.523425 0.9791377 0.08637219 21.85484 21.95177 23.22672 2.849445 0.45909643 0.08141197 0.2932833 0.3126 0.3106333 -0.001966667 1.000000e+00 6.152699e-11 FALSE TRUE
ENST00000531283 ENSG00000137509 HEK293_OSMI2_2hA HEK293_TMG_2hB PRCP protein_coding retained_intron 73.72512 70.46929 74.81766 8.523425 0.9791377 0.08637219 25.29891 18.20948 28.68337 2.298956 1.01772193 0.65523569 0.3429125 0.2598 0.3832000 0.123400000 3.779521e-03 6.152699e-11 FALSE TRUE
ENST00000680524 ENSG00000137509 HEK293_OSMI2_2hA HEK293_TMG_2hB PRCP protein_coding protein_coding 73.72512 70.46929 74.81766 8.523425 0.9791377 0.08637219 24.49311 28.81608 20.15095 4.137625 0.08896876 -0.51581089 0.3362042 0.4065 0.2694333 -0.137066667 6.152699e-11 6.152699e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000137509 E001 3.1530849 0.0243266192 1.804967e-01 3.018054e-01 11 82822936 82823043 108 - 0.723 0.512 -0.929
ENSG00000137509 E002 42.4609801 0.0004995302 5.716195e-04 2.427713e-03 11 82823044 82824364 1321 - 1.728 1.556 -0.583
ENSG00000137509 E003 6.9971844 0.0118009470 5.677388e-01 6.944992e-01 11 82824365 82824366 2 - 0.934 0.871 -0.241
ENSG00000137509 E004 8.9962735 0.0253434946 6.819008e-01 7.855045e-01 11 82824367 82824367 1 - 0.966 1.025 0.217
ENSG00000137509 E005 13.3798709 0.0394284555 5.660895e-01 6.931039e-01 11 82824368 82824372 5 - 1.110 1.182 0.259
ENSG00000137509 E006 23.9679992 0.0087319072 4.219998e-03 1.375871e-02 11 82824373 82824388 16 - 1.243 1.496 0.879
ENSG00000137509 E007 46.7095025 0.0060539866 6.626716e-03 2.025512e-02 11 82824389 82824399 11 - 1.571 1.754 0.622
ENSG00000137509 E008 1305.4107279 0.0011659094 8.618550e-13 2.139359e-11 11 82824400 82825122 723 - 3.045 3.167 0.404
ENSG00000137509 E009 0.7696683 0.0155214047 6.141647e-01 7.327116e-01 11 82825123 82825450 328 - 0.299 0.215 -0.623
ENSG00000137509 E010 1.2586568 0.0107288469 4.362239e-01 5.783237e-01 11 82825451 82825599 149 - 0.423 0.293 -0.775
ENSG00000137509 E011 0.6172225 0.4364197247 5.246466e-01 6.581167e-01 11 82825600 82831438 5839 - 0.297 0.121 -1.607
ENSG00000137509 E012 1.2952903 0.0107419579 1.349017e-01 2.409556e-01 11 82836560 82838268 1709 - 0.474 0.216 -1.621
ENSG00000137509 E013 2.6582436 0.0072821577 6.967999e-01 7.970646e-01 11 82838269 82838386 118 - 0.520 0.590 0.325
ENSG00000137509 E014 561.5617674 0.0001805068 3.710706e-04 1.662407e-03 11 82838387 82838574 188 - 2.717 2.783 0.221
ENSG00000137509 E015 440.0760016 0.0006329982 3.535134e-02 8.232480e-02 11 82839261 82839425 165 - 2.618 2.670 0.172
ENSG00000137509 E016 1.4433799 0.0106004552 1.096722e-01 2.050822e-01 11 82839426 82839849 424 - 0.220 0.511 1.767
ENSG00000137509 E017 0.9243042 0.0142701339 9.425999e-01 9.679662e-01 11 82839850 82840843 994 - 0.299 0.293 -0.040
ENSG00000137509 E018 0.1817044 0.0403808692 5.007533e-01   11 82843184 82843304 121 - 0.000 0.121 11.601
ENSG00000137509 E019 0.2987644 0.0293447001 1.927206e-01   11 82843305 82845610 2306 - 0.220 0.000 -13.603
ENSG00000137509 E020 0.0000000       11 82845611 82845615 5 -      
ENSG00000137509 E021 0.1515154 0.0430258508 4.781820e-01   11 82845616 82845752 137 - 0.124 0.000 -12.409
ENSG00000137509 E022 0.1451727 0.0435426574 4.788518e-01   11 82845753 82845984 232 - 0.124 0.000 -12.402
ENSG00000137509 E023 0.1451727 0.0435426574 4.788518e-01   11 82845985 82846179 195 - 0.124 0.000 -12.402
ENSG00000137509 E024 1.4393170 0.0092481883 2.832320e-01 4.233263e-01 11 82848749 82849048 300 - 0.474 0.293 -1.037
ENSG00000137509 E025 234.4327923 0.0003174713 4.267050e-01 5.695222e-01 11 82849049 82849076 28 - 2.358 2.389 0.101
ENSG00000137509 E026 417.4488437 0.0005362768 7.644585e-01 8.475316e-01 11 82849077 82849211 135 - 2.622 2.625 0.010
ENSG00000137509 E027 202.1144913 0.0002339172 1.317445e-02 3.631715e-02 11 82849212 82849218 7 - 2.337 2.286 -0.170
ENSG00000137509 E028 447.9017139 0.0007166715 1.604721e-01 2.757582e-01 11 82849914 82850050 137 - 2.665 2.644 -0.070
ENSG00000137509 E029 189.3579561 0.0002772166 7.210378e-01 8.155357e-01 11 82850051 82850071 21 - 2.271 2.292 0.069
ENSG00000137509 E030 0.4449813 0.0211401014 5.399854e-01 6.711864e-01 11 82850072 82850323 252 - 0.220 0.121 -1.039
ENSG00000137509 E031 433.6025831 0.0001921717 2.784970e-01 4.181726e-01 11 82850324 82850472 149 - 2.647 2.640 -0.022
ENSG00000137509 E032 309.9879837 0.0009461852 2.573272e-04 1.205772e-03 11 82850473 82850505 33 - 2.538 2.462 -0.252
ENSG00000137509 E033 1.3296439 0.0100044056 5.307538e-01 6.632961e-01 11 82850506 82853176 2671 - 0.299 0.416 0.699
ENSG00000137509 E034 404.1708023 0.0001446486 1.382565e-08 1.660893e-07 11 82853177 82853278 102 - 2.658 2.571 -0.292
ENSG00000137509 E035 1.5207984 0.0129707746 1.091564e-01 2.043011e-01 11 82853279 82853679 401 - 0.220 0.511 1.768
ENSG00000137509 E036 0.1472490 0.0432169451 4.783993e-01   11 82858283 82858771 489 - 0.124 0.000 -12.406
ENSG00000137509 E037 412.5031134 0.0012431793 1.832093e-06 1.437084e-05 11 82859977 82860117 141 - 2.673 2.567 -0.351
ENSG00000137509 E038 0.0000000       11 82861202 82861222 21 -      
ENSG00000137509 E039 1.4778248 0.1108788814 8.023979e-01 8.741137e-01 11 82879221 82879837 617 - 0.423 0.409 -0.076
ENSG00000137509 E040 5.0759912 0.0033796106 1.228930e-01 2.240823e-01 11 82884823 82884885 63 - 0.880 0.686 -0.774
ENSG00000137509 E041 0.1451727 0.0435426574 4.788518e-01   11 82887549 82887594 46 - 0.124 0.000 -12.402
ENSG00000137509 E042 0.1515154 0.0430258508 4.781820e-01   11 82887791 82887996 206 - 0.124 0.000 -12.409
ENSG00000137509 E043 0.4417591 0.0406000478 6.131283e-01 7.319212e-01 11 82892111 82893484 1374 - 0.124 0.215 0.956
ENSG00000137509 E044 0.1451727 0.0435426574 4.788518e-01   11 82893485 82893624 140 - 0.124 0.000 -12.402
ENSG00000137509 E045 327.8016306 0.0030166758 3.389803e-07 3.102807e-06 11 82900235 82900480 246 - 2.598 2.436 -0.540
ENSG00000137509 E046 0.0000000       11 82900651 82900781 131 -      
ENSG00000137509 E047 0.0000000       11 82900782 82900946 165 -      
ENSG00000137509 E048 0.0000000       11 82901459 82901468 10 -      
ENSG00000137509 E049 0.0000000       11 82901469 82901488 20 -      
ENSG00000137509 E050 0.0000000       11 82901489 82901570 82 -      
ENSG00000137509 E051 0.0000000       11 82901571 82901592 22 -      
ENSG00000137509 E052 0.8856962 0.0141577298 3.759311e-01 5.203108e-01 11 82901593 82901740 148 - 0.365 0.215 -1.040
ENSG00000137509 E053 0.0000000       11 82957065 82957115 51 -      
ENSG00000137509 E054 0.0000000       11 82970482 82970584 103 -