ENSG00000137500

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000455220 ENSG00000137500 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC90B protein_coding protein_coding 20.45451 9.010975 36.07719 0.5288446 1.585857 2.000132 3.409433 2.5087012 6.8067550 0.61671847 0.99879568 1.4364051 0.20467917 0.27293333 0.18700000 -0.085933333 0.43967144 0.02567788 FALSE TRUE
ENST00000525503 ENSG00000137500 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC90B protein_coding protein_coding 20.45451 9.010975 36.07719 0.5288446 1.585857 2.000132 3.756192 1.5267623 5.3271938 0.22064232 0.94775431 1.7961874 0.16981250 0.17326667 0.14976667 -0.023500000 0.87224881 0.02567788 FALSE TRUE
ENST00000525504 ENSG00000137500 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC90B protein_coding processed_transcript 20.45451 9.010975 36.07719 0.5288446 1.585857 2.000132 0.584153 0.1390534 0.6460354 0.04852135 0.05340240 2.1379440 0.05162083 0.01500000 0.01793333 0.002933333 0.96852898 0.02567788   FALSE
ENST00000527495 ENSG00000137500 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC90B protein_coding protein_coding 20.45451 9.010975 36.07719 0.5288446 1.585857 2.000132 1.503588 1.0965690 2.7580198 0.22807496 0.62040432 1.3227609 0.07316667 0.12513333 0.07523333 -0.049900000 0.50803031 0.02567788 FALSE TRUE
ENST00000529611 ENSG00000137500 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC90B protein_coding protein_coding 20.45451 9.010975 36.07719 0.5288446 1.585857 2.000132 1.372472 0.5867569 2.2224770 0.08310132 0.01300657 1.9034300 0.06566250 0.06543333 0.06186667 -0.003566667 0.94828420 0.02567788 FALSE TRUE
ENST00000529745 ENSG00000137500 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC90B protein_coding nonsense_mediated_decay 20.45451 9.010975 36.07719 0.5288446 1.585857 2.000132 4.445426 0.9366263 9.7481319 0.47978948 1.04833858 3.3657380 0.19095000 0.10010000 0.26973333 0.169633333 0.44076595 0.02567788 FALSE TRUE
MSTRG.6103.8 ENSG00000137500 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC90B protein_coding   20.45451 9.010975 36.07719 0.5288446 1.585857 2.000132 1.139934 0.9602987 1.0809948 0.17874616 0.35782374 0.1691433 0.05693750 0.10906667 0.03096667 -0.078100000 0.03316753 0.02567788 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000137500 E001 27.2676070 0.0008924959 2.453010e-01 3.803886e-01 11 83259081 83261316 2236 - 1.432 1.343 -0.308
ENSG00000137500 E002 5.2603426 0.0030669222 8.786159e-01 9.260353e-01 11 83261317 83261455 139 - 0.766 0.744 -0.089
ENSG00000137500 E003 3.5577315 0.1110815796 1.397960e-01 2.477450e-01 11 83261456 83261461 6 - 0.511 0.795 1.226
ENSG00000137500 E004 83.9915702 0.0003571079 7.189823e-03 2.171839e-02 11 83261462 83261729 268 - 1.852 1.964 0.375
ENSG00000137500 E005 52.7359356 0.0014874827 5.161438e-01 6.507123e-01 11 83261730 83261756 27 - 1.702 1.667 -0.119
ENSG00000137500 E006 81.9716315 0.0003519897 7.642911e-01 8.474047e-01 11 83261757 83261794 38 - 1.874 1.888 0.044
ENSG00000137500 E007 64.0437324 0.0004240983 4.872406e-01 6.249155e-01 11 83261795 83261795 1 - 1.762 1.795 0.114
ENSG00000137500 E008 123.2491750 0.0002479219 6.760506e-03 2.060189e-02 11 83261796 83261890 95 - 2.024 2.116 0.310
ENSG00000137500 E009 92.2575844 0.0015243427 1.128999e-03 4.401207e-03 11 83261891 83261928 38 - 1.885 2.023 0.463
ENSG00000137500 E010 97.4134223 0.0002988848 2.098337e-02 5.355369e-02 11 83261929 83261966 38 - 1.925 2.014 0.299
ENSG00000137500 E011 94.7903689 0.0003463253 2.406328e-01 3.749067e-01 11 83265865 83265889 25 - 1.925 1.972 0.156
ENSG00000137500 E012 80.1516071 0.0003311425 3.108564e-01 4.532961e-01 11 83265890 83265899 10 - 1.853 1.897 0.147
ENSG00000137500 E013 85.4092750 0.0003156309 1.138906e-01 2.111966e-01 11 83265900 83265915 16 - 1.873 1.939 0.221
ENSG00000137500 E014 112.0301587 0.0002763487 5.584595e-02 1.194227e-01 11 83265916 83265979 64 - 1.989 2.058 0.231
ENSG00000137500 E015 2.3055352 0.0169893483 2.921498e-01 4.330914e-01 11 83266867 83267038 172 - 0.534 0.330 -1.089
ENSG00000137500 E016 2.3441432 0.0321049520 6.963692e-01 7.967355e-01 11 83267039 83267472 434 - 0.510 0.433 -0.389
ENSG00000137500 E017 0.7512344 0.2814216217 3.135869e-01 4.561992e-01 11 83273246 83273646 401 - 0.287 0.000 -10.504
ENSG00000137500 E018 104.8391983 0.0004191742 1.134874e-01 2.106134e-01 11 83273647 83273676 30 - 1.962 2.022 0.200
ENSG00000137500 E019 98.1112063 0.0003346289 5.339317e-01 6.660506e-01 11 83273677 83273700 24 - 1.945 1.969 0.081
ENSG00000137500 E020 0.6319842 0.0278285657 1.000000e+00 1.000000e+00 11 83273701 83273738 38 - 0.193 0.196 0.027
ENSG00000137500 E021 147.2304250 0.0002496046 8.886974e-01 9.328217e-01 11 83273793 83273864 72 - 2.127 2.131 0.014
ENSG00000137500 E022 0.7437457 0.0153787590 8.241295e-01 8.892026e-01 11 83273865 83273950 86 - 0.242 0.195 -0.390
ENSG00000137500 E023 118.2507965 0.0002541467 3.149200e-01 4.576642e-01 11 83273951 83273992 42 - 2.044 2.007 -0.123
ENSG00000137500 E024 2.5078610 0.0104280267 1.975698e-02 5.097167e-02 11 83273993 83274176 184 - 0.362 0.745 1.805
ENSG00000137500 E025 1.1458486 0.0588750929 3.765279e-03 1.248287e-02 11 83274177 83274442 266 - 0.074 0.588 3.946
ENSG00000137500 E026 2.2476925 0.0257873499 2.994292e-02 7.184595e-02 11 83274443 83274638 196 - 0.326 0.699 1.841
ENSG00000137500 E027 159.9164615 0.0002056035 1.423332e-01 2.512214e-01 11 83274639 83274740 102 - 2.175 2.129 -0.154
ENSG00000137500 E028 0.1451727 0.0432570718 1.000000e+00   11 83274741 83274763 23 - 0.074 0.000 -8.174
ENSG00000137500 E029 112.2978874 0.0003201372 1.088261e-01 2.038097e-01 11 83278726 83278829 104 - 2.028 1.966 -0.205
ENSG00000137500 E030 0.0000000       11 83278830 83278830 1 -      
ENSG00000137500 E031 154.1433590 0.0002689907 3.040702e-04 1.395914e-03 11 83280141 83280260 120 - 2.180 2.062 -0.396
ENSG00000137500 E032 10.9120849 0.0035917048 1.877310e-01 3.108780e-01 11 83285127 83285211 85 - 1.079 0.924 -0.572
ENSG00000137500 E033 14.1091388 0.0013581624 2.495269e-01 3.853570e-01 11 83285212 83285552 341 - 1.170 1.051 -0.428
ENSG00000137500 E034 55.9519620 0.0098011472 6.123968e-01 7.313438e-01 11 83285553 83285872 320 - 1.723 1.683 -0.138
ENSG00000137500 E035 103.7955439 0.0002853422 6.860432e-09 8.720984e-08 11 83285873 83286099 227 - 2.034 1.787 -0.828
ENSG00000137500 E036 77.0750308 0.0015137415 5.307348e-06 3.755083e-05 11 83286100 83286390 291 - 1.904 1.667 -0.799