ENSG00000137497

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000393695 ENSG00000137497 HEK293_OSMI2_2hA HEK293_TMG_2hB NUMA1 protein_coding protein_coding 50.73834 66.76115 35.48317 2.06801 0.4419783 -0.9116835 7.826567 10.089284 5.3683039 0.7344185 0.29939987 -0.9090298 0.15036667 0.1508 0.151133333 0.0003333333 1.000000e+00 3.259145e-61 FALSE TRUE
ENST00000540626 ENSG00000137497 HEK293_OSMI2_2hA HEK293_TMG_2hB NUMA1 protein_coding retained_intron 50.73834 66.76115 35.48317 2.06801 0.4419783 -0.9116835 7.379770 12.052487 1.9074429 2.8444689 0.57922199 -2.6532719 0.13040417 0.1827 0.053366667 -0.1293333333 3.419447e-02 3.259145e-61 FALSE TRUE
ENST00000541584 ENSG00000137497 HEK293_OSMI2_2hA HEK293_TMG_2hB NUMA1 protein_coding protein_coding 50.73834 66.76115 35.48317 2.06801 0.4419783 -0.9116835 4.725058 14.199002 0.2487977 1.6667972 0.12560144 -5.7788365 0.06964167 0.2128 0.006933333 -0.2058666667 6.307805e-05 3.259145e-61 FALSE TRUE
ENST00000545721 ENSG00000137497 HEK293_OSMI2_2hA HEK293_TMG_2hB NUMA1 protein_coding nonsense_mediated_decay 50.73834 66.76115 35.48317 2.06801 0.4419783 -0.9116835 3.497194 2.014258 2.9485357 0.2079004 0.09550588 0.5474903 0.07560833 0.0300 0.083100000 0.0531000000 7.074902e-10 3.259145e-61 TRUE TRUE
ENST00000620566 ENSG00000137497 HEK293_OSMI2_2hA HEK293_TMG_2hB NUMA1 protein_coding protein_coding 50.73834 66.76115 35.48317 2.06801 0.4419783 -0.9116835 14.738972 18.778443 10.2606870 2.4334848 0.86265223 -0.8713128 0.28418750 0.2800 0.289233333 0.0092333333 9.510052e-01 3.259145e-61 FALSE TRUE
MSTRG.5914.1 ENSG00000137497 HEK293_OSMI2_2hA HEK293_TMG_2hB NUMA1 protein_coding   50.73834 66.76115 35.48317 2.06801 0.4419783 -0.9116835 2.551086 3.790792 2.3508934 0.8836656 1.18860341 -0.6869672 0.05293750 0.0566 0.066533333 0.0099333333 9.348236e-01 3.259145e-61 FALSE TRUE
MSTRG.5914.7 ENSG00000137497 HEK293_OSMI2_2hA HEK293_TMG_2hB NUMA1 protein_coding   50.73834 66.76115 35.48317 2.06801 0.4419783 -0.9116835 3.263005 0.000000 5.5701507 0.0000000 0.32973863 9.1241603 0.08999583 0.0000 0.157066667 0.1570666667 3.259145e-61 3.259145e-61 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000137497 E001 3.2792237 0.1250996600 1.321520e-03 5.048761e-03 11 72002864 72002864 1 - 0.000 0.758 13.322
ENSG00000137497 E002 629.0042328 0.0048654219 1.936289e-18 1.029249e-16 11 72002865 72003263 399 - 2.500 2.855 1.182
ENSG00000137497 E003 863.9381353 0.0072382917 2.142787e-10 3.569685e-09 11 72003264 72003538 275 - 2.684 2.982 0.990
ENSG00000137497 E004 717.8987518 0.0060017946 9.412582e-09 1.167006e-07 11 72003887 72004099 213 - 2.638 2.893 0.848
ENSG00000137497 E005 491.4788050 0.0029938356 1.373174e-08 1.650134e-07 11 72004225 72004341 117 - 2.513 2.717 0.682
ENSG00000137497 E006 542.9439234 0.0022959386 1.150554e-09 1.686022e-08 11 72004640 72004816 177 - 2.561 2.759 0.658
ENSG00000137497 E007 201.0098750 0.0010135220 6.113244e-07 5.317428e-06 11 72005233 72005242 10 - 2.143 2.322 0.598
ENSG00000137497 E008 279.5164074 0.0016774879 2.099023e-08 2.437499e-07 11 72005243 72005285 43 - 2.274 2.470 0.651
ENSG00000137497 E009 326.3674306 0.0005526707 3.167884e-12 7.166780e-11 11 72005286 72005369 84 - 2.344 2.536 0.638
ENSG00000137497 E010 580.6973313 0.0004651722 7.182964e-09 9.088299e-08 11 72006035 72006263 229 - 2.640 2.770 0.433
ENSG00000137497 E011 581.5321527 0.0015089506 7.099726e-04 2.934614e-03 11 72007189 72007435 247 - 2.660 2.764 0.348
ENSG00000137497 E012 75.2042893 0.0129201801 2.059467e-03 7.409741e-03 11 72007436 72007925 490 - 1.972 1.781 -0.642
ENSG00000137497 E013 38.8272783 0.0007452367 1.435230e-04 7.188366e-04 11 72007926 72008091 166 - 1.693 1.494 -0.676
ENSG00000137497 E014 23.8715310 0.0016733839 1.189452e-01 2.184271e-01 11 72008092 72008145 54 - 1.422 1.326 -0.335
ENSG00000137497 E015 46.0711332 0.0069278805 1.655189e-03 6.138229e-03 11 72008146 72008437 292 - 1.753 1.568 -0.630
ENSG00000137497 E016 34.8925871 0.0008423668 2.688374e-05 1.617610e-04 11 72008438 72008687 250 - 1.665 1.432 -0.797
ENSG00000137497 E017 403.4733644 0.0002564325 8.956297e-12 1.880673e-10 11 72008688 72008845 158 - 2.458 2.620 0.538
ENSG00000137497 E018 443.3404315 0.0001502450 5.164027e-17 2.295962e-15 11 72008967 72009185 219 - 2.482 2.665 0.608
ENSG00000137497 E019 313.6411079 0.0009345749 8.961979e-09 1.114640e-07 11 72009268 72009387 120 - 2.338 2.512 0.581
ENSG00000137497 E020 274.0910920 0.0002338898 9.026692e-06 6.063253e-05 11 72010786 72010854 69 - 2.313 2.441 0.426
ENSG00000137497 E021 3.4665319 0.0065775448 8.596513e-01 9.134771e-01 11 72012259 72012400 142 - 0.604 0.647 0.187
ENSG00000137497 E022 53.7777247 0.0005555959 2.984628e-03 1.021810e-02 11 72012401 72012442 42 - 1.571 1.751 0.611
ENSG00000137497 E023 2379.4950829 0.0008877323 9.916204e-02 1.892009e-01 11 72012895 72014947 2053 - 3.312 3.360 0.158
ENSG00000137497 E024 631.8879273 0.0018073539 3.125305e-02 7.439309e-02 11 72014948 72015428 481 - 2.789 2.759 -0.098
ENSG00000137497 E025 844.8367128 0.0032761939 8.586051e-07 7.233842e-06 11 72015429 72016260 832 - 2.973 2.854 -0.396
ENSG00000137497 E026 218.5387445 0.0002095245 2.039550e-11 4.035369e-10 11 72016408 72016530 123 - 2.404 2.256 -0.494
ENSG00000137497 E027 4.0631834 0.0040333601 1.976127e-05 1.227004e-04 11 72016976 72017279 304 - 0.983 0.393 -2.549
ENSG00000137497 E028 4.4419292 0.0109475059 4.037167e-02 9.169845e-02 11 72017280 72017686 407 - 0.873 0.597 -1.131
ENSG00000137497 E029 241.5844153 0.0005537678 9.203457e-10 1.373645e-08 11 72017687 72017827 141 - 2.441 2.305 -0.455
ENSG00000137497 E030 242.9375094 0.0003523459 2.952656e-11 5.693352e-10 11 72018183 72018300 118 - 2.446 2.302 -0.479
ENSG00000137497 E031 238.3344316 0.0009806389 4.403884e-08 4.801466e-07 11 72018396 72018513 118 - 2.430 2.299 -0.437
ENSG00000137497 E032 192.2489868 0.0028887924 4.523685e-07 4.035593e-06 11 72018823 72018902 80 - 2.357 2.195 -0.543
ENSG00000137497 E033 179.7753147 0.0067189920 1.737129e-06 1.369569e-05 11 72018903 72018961 59 - 2.352 2.149 -0.680
ENSG00000137497 E034 131.5383548 0.0065403004 2.431060e-05 1.479179e-04 11 72018962 72018980 19 - 2.208 2.021 -0.626
ENSG00000137497 E035 168.7448932 0.0096392805 1.515719e-05 9.663861e-05 11 72019494 72019555 62 - 2.331 2.119 -0.707
ENSG00000137497 E036 147.2215045 0.0077907349 1.559754e-05 9.914797e-05 11 72019556 72019598 43 - 2.265 2.064 -0.670
ENSG00000137497 E037 106.0727458 0.0024307708 4.335990e-10 6.865933e-09 11 72019599 72019600 2 - 2.144 1.905 -0.802
ENSG00000137497 E038 117.4308795 0.0037809474 4.777115e-07 4.241904e-06 11 72019601 72019617 17 - 2.167 1.966 -0.673
ENSG00000137497 E039 118.7099001 0.0028078767 1.515738e-05 9.663861e-05 11 72021204 72021225 22 - 2.147 1.989 -0.531
ENSG00000137497 E040 184.4198786 0.0036116200 2.177813e-08 2.521603e-07 11 72021226 72021291 66 - 2.359 2.163 -0.656
ENSG00000137497 E041 1.1394067 0.0111588576 6.818034e-01 7.854065e-01 11 72022202 72022338 137 - 0.360 0.297 -0.397
ENSG00000137497 E042 141.6982286 0.0088748487 2.800542e-06 2.110483e-05 11 72022339 72022382 44 - 2.266 2.036 -0.769
ENSG00000137497 E043 128.1726651 0.0026949400 1.118371e-09 1.643438e-08 11 72022383 72022419 37 - 2.218 1.996 -0.746
ENSG00000137497 E044 114.2068725 0.0072661616 2.698184e-06 2.040733e-05 11 72023065 72023081 17 - 2.172 1.947 -0.754
ENSG00000137497 E045 125.3559494 0.0083464102 9.417047e-06 6.297322e-05 11 72023082 72023107 26 - 2.207 1.990 -0.726
ENSG00000137497 E046 115.6438073 0.0126367652 1.107313e-04 5.712262e-04 11 72023108 72023129 22 - 2.174 1.953 -0.740
ENSG00000137497 E047 100.8820669 0.0138525107 8.600023e-05 4.562827e-04 11 72023130 72023137 8 - 2.125 1.887 -0.797
ENSG00000137497 E048 100.8812222 0.0144640216 1.119575e-04 5.768292e-04 11 72023138 72023147 10 - 2.123 1.887 -0.792
ENSG00000137497 E049 0.5149242 0.2216240259 1.000000e+00 1.000000e+00 11 72024071 72024273 203 - 0.156 0.174 0.193
ENSG00000137497 E050 106.3455101 0.0156482166 2.295553e-04 1.090130e-03 11 72024274 72024298 25 - 2.143 1.913 -0.770
ENSG00000137497 E051 88.7542386 0.0087908751 1.655248e-05 1.046005e-04 11 72024299 72024304 6 - 2.065 1.835 -0.772
ENSG00000137497 E052 88.7979181 0.0056074758 1.369235e-06 1.104148e-05 11 72024305 72024312 8 - 2.065 1.836 -0.770
ENSG00000137497 E053 141.4760125 0.0003216085 3.430839e-16 1.378499e-14 11 72024313 72024353 41 - 2.264 2.033 -0.774
ENSG00000137497 E054 0.1515154 0.0433531972 2.702934e-01   11 72024354 72024850 497 - 0.156 0.000 -13.455
ENSG00000137497 E055 158.5223591 0.0002430703 5.530101e-14 1.630601e-12 11 72029205 72029290 86 - 2.295 2.096 -0.664
ENSG00000137497 E056 139.8869347 0.0008836071 8.498937e-15 2.827214e-13 11 72035902 72035975 74 - 2.262 2.026 -0.790
ENSG00000137497 E057 0.4783925 0.0212397120 2.748792e-01 4.141057e-01 11 72035976 72035987 12 - 0.270 0.095 -1.812
ENSG00000137497 E058 0.1515154 0.0433531972 2.702934e-01   11 72039735 72039825 91 - 0.156 0.000 -13.455
ENSG00000137497 E059 0.5546650 0.0204813495 9.710508e-01 9.859138e-01 11 72040605 72040958 354 - 0.156 0.174 0.190
ENSG00000137497 E060 16.5156895 0.0012844563 1.805652e-02 4.725386e-02 11 72040959 72041146 188 - 1.328 1.147 -0.638
ENSG00000137497 E061 0.3299976 0.0274424043 4.205660e-01   11 72041428 72041525 98 - 0.000 0.173 13.038
ENSG00000137497 E062 0.0000000       11 72041722 72041822 101 -      
ENSG00000137497 E063 0.5138669 0.0206015831 2.757795e-01 4.151550e-01 11 72041823 72042142 320 - 0.270 0.096 -1.810
ENSG00000137497 E064 15.0860301 0.0018615423 3.935964e-04 1.750203e-03 11 72049419 72049539 121 - 1.353 1.063 -1.029
ENSG00000137497 E065 1.7286434 0.1757764486 1.411927e-01 2.496690e-01 11 72050662 72050833 172 - 0.604 0.297 -1.624
ENSG00000137497 E066 0.1472490 0.0431385513 2.706496e-01   11 72062589 72062686 98 - 0.156 0.000 -13.457
ENSG00000137497 E067 0.8178402 0.0885778462 4.961737e-01 6.328978e-01 11 72065199 72068078 2880 - 0.156 0.295 1.175
ENSG00000137497 E068 1.6512104 0.0083618597 3.466203e-01 4.907419e-01 11 72068079 72068104 26 - 0.499 0.348 -0.811
ENSG00000137497 E069 10.0528853 0.0268525666 1.786811e-01 2.994912e-01 11 72068105 72068231 127 - 1.102 0.953 -0.548
ENSG00000137497 E070 1.9091767 0.0076911829 2.955224e-02 7.107972e-02 11 72068496 72068617 122 - 0.648 0.297 -1.811
ENSG00000137497 E071 110.4273777 0.0007383821 6.654936e-14 1.938434e-12 11 72069842 72069911 70 - 2.169 1.921 -0.833
ENSG00000137497 E072 0.0000000       11 72069912 72070093 182 -      
ENSG00000137497 E073 0.4396707 0.0262086908 2.515122e-02 6.218859e-02 11 72076568 72076757 190 - 0.360 0.000 -15.333
ENSG00000137497 E074 18.0113165 0.0091372822 1.087834e-01 2.037418e-01 11 72080320 72080457 138 - 1.327 1.199 -0.451
ENSG00000137497 E075 85.4100423 0.0006207749 4.285721e-14 1.283460e-12 11 72080458 72080693 236 - 2.074 1.795 -0.938